Nancy Maltez
A5015572260- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Inflammatory Myopathies and Dermatomyositis
- Diagnosis and Treatment of Venous Diseases
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Rheumatoid Arthritis Research and Therapies
- Colorectal Cancer Treatments and Studies
- Skin Diseases and Diabetes
- Patient Satisfaction in Healthcare
- Telemedicine and Telehealth Implementation
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- COVID-19 and Mental Health
- Osteoarthritis Treatment and Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Body Image and Dysmorphia Studies
- Problem and Project Based Learning
- Multiple Sclerosis Research Studies
- Fungal and yeast genetics research
- Prenatal Substance Exposure Effects
- Inflammasome and immune disorders
- Sympathectomy and Hyperhidrosis Treatments
University of Ottawa
2010-2025
Ottawa Hospital
2019-2025
Ottawa Hospital Research Institute
2021-2024
Jewish General Hospital
2021
McGill University
2021
Salford Royal NHS Foundation Trust
2020
In gout, hyperuricemia promotes urate crystal deposition, which stimulates the NLRP3 inflammasome and interleukin-1β (IL-1β)-mediated arthritis. Incident gout without background is rarely reported. To identify hyperuricemia-independent mechanisms driving incidence progression, we characterized erosive crystalline inflammatory arthritis in a young female patient with normouricemia diagnosed as having sufficient weighted classification criteria for according to American College of Rheumatology...
Immunotherapy, including the use of immune checkpoint inhibitors (ICI), is now a well-established pillar cancer therapy. Exploitation regulatory mechanisms through inhibition checkpoints has led to unprecedented responses in advanced malignancies, heralded as one most promising therapeutics history treatment (Hargadon, Johnson, and Williams 2018). Since FDA approval ipilimumab for metastatic melanoma 2011, there have been an additional eight ICI receive over dozen different indications (Luke...
The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate increase uptake and remodel cellular metabolism survive low-iron conditions. In addition, has been implicated numerous processes including cell-cycle progression chromosome stability; however, it unclear if all effects are mediated through homeostasis. To further investigate affected by Aft1, we identified >70 deletion mutants that...
To quantify the magnitude, domains, and duration of change in health-related quality life (HRQoL) patients with systemic sclerosis (SSc) who underwent autologous hematopoietic stem cell transplantation (HSCT) as compared to SSc similar characteristics did not undergo HSCT.The study was designed a retrospective comparing HSCT met criteria for but were treated conventional care. Outcomes included scores on 36-item Short Form (SF-36) health survey Health Assessment Questionnaire (HAQ) its...
Abstract Objectives To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors. Methods Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used assess associations sociodemographic, lifestyle, disease-related variables. Results Among...
To investigate whether sarcopenic obesity may contribute to knee osteoarthritis or not.In this study, we assessed 140 community-dwelling adult patients. Their demographic data were recorded along with comorbidities. Anterior mid-thigh muscle thickness in the axial plane was measured on dominant leg using ultrasound midway between anterior superior iliac spine and upper end of patella millimeter. Then, sonographic thigh adjustment ratio calcu- lated by dividing body mass index. ISarcoPRM...
Digital ulcers (DU) are a common, severe vascular manifestation of systemic sclerosis (SSc) with few effective treatment options. Using data from the Australian Scleroderma Cohort Study (ASCS), we sought to evaluate effect calcium channel blockers (CCB) on and prevention DU.Using 1953 participants, median 4.34 years follow-up, used generalised estimating equations clinical characteristics associated CCB use ascertain risk factors for presence DU at subsequent study visits. A time-dependent...
The Scleroderma Patient-centered Intervention Network (SPIN) developed an online self-management program (SPIN-SELF) designed to improve disease-management self-efficacy in people with systemic sclerosis (SSc, or scleroderma). aim of this study was evaluate feasibility aspects for conducting a full-scale randomized controlled trial (RCT) the SPIN-SELF Program. This embedded SPIN Cohort and utilized cohort multiple RCT design. In design, at time enrollment, participants consent be assessed...
Abstract Background Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. Functional impairment of hands common. The Scleroderma Patient-centered Intervention Network (SPIN)-HAND trial compared effects offering access to an online self-guided hand exercise program usual care on function (primary) and functional health outcomes (secondary) in people with SSc at least mild limitations. Methods pragmatic, two-arm, parallel-group cohort multiple randomized...
Systemic sclerosis is a heterogenous disease in which little known about patterns of patient-reported symptom clusters. We aimed to identify classes individuals with similar anxiety, depression, fatigue, sleep disturbance, and pain symptoms evaluate associated sociodemographic disease-related characteristics.