A5062895598- HIV/AIDS Research and Interventions
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Policy and Management
- COVID-19 Clinical Research Studies
- Protease and Inhibitor Mechanisms
- Poxvirus research and outbreaks
- Pneumocystis jirovecii pneumonia detection and treatment
- Central Venous Catheters and Hemodialysis
- Cell Adhesion Molecules Research
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- Neuroscience and Neuropharmacology Research
- Data-Driven Disease Surveillance
- Patient Safety and Medication Errors
- Opioid Use Disorder Treatment
- Osteoarthritis Treatment and Mechanisms
- Dupuytren's Contracture and Treatments
- COVID-19 and healthcare impacts
- X-ray Diffraction in Crystallography
- Immunodeficiency and Autoimmune Disorders
- Cystic Fibrosis Research Advances
- Medical Coding and Health Information
- Macrophage Migration Inhibitory Factor
- Disaster Response and Management
- Foreign Body Medical Cases
New York City Health and Hospitals Corporation
2022-2025
Oregon Medical Research Center
2023
Advisory Board Company (United States)
2023
New York University
2012-2023
Bellevue Hospital Center
2020-2023
University of Pittsburgh
2023
Lindsay Unified School District
2023
New York Proton Center
2023
Communities In Schools of Orange County
2023
Manhattan Institute for Policy Research
2023
Mongolian gerbils were treated with alpha-methyl-para-tyrosine methyl ester (AMPT, a tyrosine hydroxylase inhibitor), in order to decrease brain levels of catecholamines. Six hours later, unilateral ischemic stroke was induced by ligation the left common carotid artery. The delayed degeneration nerve terminals studied sixteen later measuring high-affinity uptake radiolabeled transmitters isolated synaptosomes. Dopamine, serotonin and glutamate studied. AMPT-treated compared untreated (no...
Despite evidence of socio-demographic disparities in outcomes COVID-19, little is known about characteristics and clinical patients admitted to public hospitals during the COVID-19 outbreak.To assess demographics, comorbid conditions, factors associated with critical illness mortality among diagnosed at a hospital New York City (NYC) first month outbreak.Retrospective chart review NYC Health + Hospitals / Bellevue Hospital from March 9th April 8th, 2020.A total 337 were study period. Primary...
Abstract Background Nationally almost 20% of new HIV diagnosis are in females. Females carry 53% sexually transmitted infection (STI) disease burden the US, yet nationally represent only 10% individuals on Pre-Exposure Prophylaxis (PrEP). The US Preventive Services Task Force and CDC include females diagnosed with bacterial STIs as one populations to be considered for PrEP. However, often not focus PrEP campaigns, resulting knowledge gaps, bias stigma that further challenge access women. As...
We conducted a retrospective study among HIV-infected adult suspects (≥18 years) with pulmonary tuberculosis (TB), who underwent Xpert MTB/RIF (Xpert) testing at McCord Hospital and its adjoining HIV clinic in Durban, South Africa.To determine if performed centralized laboratory accelerated time to TB diagnosis.We obtained data on sputum smear microscopy [acid-fast bacilli (AFB)], Xpert, the rationale for treatment initiation from medical records. The primary outcome was "total diagnostic...
To evaluate the impact of ICU surge on mortality and to explore clinical sociodemographic predictors mortality.Retrospective cohort analysis.NYC Health + Hospitals ICUs.Adult patients with coronavirus disease 2019 admitted between March 24, May 12, 2020.None.Hospitals reported levels daily. Uni- multivariable analyses were conducted assess factors impacting in-hospital mortality. Mortality in Hispanic was higher for high/very high compared low/medium (69.6% vs 56.4%; p = 0.0011). Patients 65...
Verruculogens are rare fumitremorgin alkaloids that contain a highly unusual eight-membered endoperoxide. In this paper, we report concise chemoenzymatic synthesis of 13-oxoverruculogen using enzymatic C-H peroxidation and rhodium-catalyzed C-C bond activation reactions to install the endoperoxide pentacyclic core natural product, respectively. Our strategy involves use 13-epi-fumitremorgin B as substrate analog for endoperoxidation by verruculogen synthase, FtmOx1. The resulting...
Similar to the early phases of COVID-19 pandemic, New York City was national epicenter ongoing 2022 mpox (formerly monkeypox) outbreak. Cases quickly began rise in July 2022, primarily gay, bisexual, or other men who have sex with men. Tools form a reliable diagnostic test, an effective vaccine, and viable treatment option been available from onset, although logistically complex roll out. The special pathogens program at NYC Health + Hospitals/Bellevue, flagship facility for largest public...
Human herpesvirus-8 (HHV-8) remains best known as an oncogenic virus, but nonneoplastic disease manifestations, such bone marrow failure or hemophagocytic lymphohistiocytosis (HLH) have gained greater recognition in recent years. In organ transplantation, HHV-8 infection commonly occurs with reactivation of latent virus among recipients from endemic regions the world due to transmission donor. We describe a case HHV-8-associated HLH liver transplant recipient at increased risk for primary...
In the spring of 2022, mpox spread to non-endemic countries, including United States. New York City (NYC), vaccine demand grew as quickly case counts. With leadership Regional Emerging Special Pathogens Treatment Center (RESPTC) at NYC Health and Hospitals/Bellevue (NYC H+H)-part largest public hospital system in States-an innovative vaccination model was established that overcame challenges involving health inequities, inadequate access, lack uptake, successfully administer JYNNEOS vaccines...
This study evaluated how educational attainment impacts clinical outcomes of HIV-positive patients in Durban, South Africa. The authors conducted a prospective 466 adult initiating antiretroviral therapy (ART) at an urban TB-HIV clinic from October 2004 to June 2007. level (highest grade completed) was assessed ART initiation. measured tuberculosis treatment as well death, lost follow-up, viral suppression (HIV RNA <400 copies/mL), and immunologic response (CD4 ≥200 cells/mm 3 ) 6, 12, 24...
Reports conflict on how HIV infection influences the clinical course of COVID-19. The New York City (NYC) public hospital system provides care for over 14,000 people with HIV, was central in responding to COVID-19 pandemic, and is therefore a unique position evaluate intersection these concurrent infections. Retrospective chart review patients presenting NYC Health Hospitals (NYC H+H) diagnosed from March 1, 2020, through April 28, compared living (PLWH) propensity-matched (PM) control group...
The distinctive feature of the human immunodeficiency virus (HIV) epidemic in Sub-Saharan Africa is burden on women, particular young women reproductive age. Consequently, most late-phase effectiveness microbicide clinical trials are conducted sub-Saharan where fertility rates high. Because over prolonged periods time, participating these may fall pregnant during trial. Their unborn babies be exposed to a drug whose teratogenic potential unknown if investigational not withdrawn. High...
Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pneumonia in otherwise healthy patients. We describe a case of community-acquired P. previously individual who likely acquired the infection from home humidifier.
Abstract Background: Peripherally inserted central catheters (PICCs) are increasingly used for vascular access in inpatient settings. Compared to multilumen PICCs, single-lumen PICCs carry a lower rate of complications, including central-line–associated bloodstream infection and thrombosis. Despite this, still overused. Methods: This quality improvement initiative was implemented across 11 hospitals at New York City Health + Hospitals safety net system. The electronic health record (EHR)...
Background Long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) was approved by the U.S. Food and Drug Administration in December 2021. This initial phase of implementation represents a prime opportunity to ensure equitable LAI-PrEP provision communities often underrepresented PrEP care before disparities access uptake emerge. Herein, we describe EquiPrEP Project which utilizes an equity-oriented science framework optimize rollout urban safety-net clinic New York City. Methods The...
Two latent collagenases whose apparent molecular weights were ca. 150 000 and 60 have been detected in human leukocytes the partial purification of high weight component was accomplished by following steps: acetone precipitation, ammonium sulphate fractionation, gel filtration on Sephacryl S-200, chromatography DEAE-Sepharose, a final S-200. After activation an activator extracted from rheumatoid synovial fluid, enzyme able to cleave collagen into classical 1/4 3/4 fragments, inhibited...