A5055723060- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Radiation Therapy and Dosimetry
- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Ocular Oncology and Treatments
- Nanoplatforms for cancer theranostics
- Boron Compounds in Chemistry
- Parallel Computing and Optimization Techniques
- X-ray Spectroscopy and Fluorescence Analysis
- Markov Chains and Monte Carlo Methods
- Advanced Fluorescence Microscopy Techniques
- Advanced Optical Sensing Technologies
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Particle Accelerators and Free-Electron Lasers
- Catalytic Processes in Materials Science
- Nuclear reactor physics and engineering
- Advanced biosensing and bioanalysis techniques
- Stochastic processes and statistical mechanics
Memorial Sloan Kettering Cancer Center
2023-2025
New York Proton Center
2022-2024
Massachusetts Institute of Technology
2013-2022
Old Dominion University
2020
University of Michigan
2015
Experimental measurements of two-dimensional (2D) dose rate distributions in proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In this study, we characterize a newly designed 2D strip-segmented ionization chamber array (SICA) with high spatial and temporal resolution demonstrate its applications modern PBS delivery system at both conventional ultrahigh rates.A dedicated research beamline the Varian ProBeam was employed to deliver 250-MeV nozzle currents up...
Abstract Background The potential reduction of normal tissue toxicities during FLASH radiotherapy (FLASH‐RT) has inspired many efforts to investigate its underlying mechanism and translate it into the clinic. Such investigations require experimental platforms FLASH‐RT capabilities. Purpose To commission characterize a 250 MeV proton research beamline with saturated nozzle monitor ionization chamber for small animal experiments. Methods A 2D strip array (SICA) high spatiotemporal resolution...
Abstract Objective . To investigate the effects of respiratory motion on delivered dose in context proton pencil beam scanning (PBS) transmission FLASH radiotherapy (FLASH-RT) by simulation and phantom measurements. Approach An in-house code was employed to perform silico 2D distributions for clinically relevant PBS FLASH-RT treatments. A moving grid introduced impacts various treatment delivery parameters dynamic delivery. strip-ionization chamber array detector an IROC platform were...
The New Small Wheel (NSW) is an upgrade for the ATLAS detector to provide enhanced triggering and reconstruction of muons in forward region. large LV power demands NSW necessitate a point-of-load architecture with on-detector conversion. radiation load magnetic field this environment, while significant, are nevertheless still range where commercial-off-the-shelf devices may suffice.
Abstract Background Several studies have shown pencil beam scanning (PBS) proton therapy is a feasible and safe modality to deliver conformal ultra‐high dose rate (UHDR) FLASH radiation therapy. However, it would be challenging burdensome conduct the quality assurance (QA) of along with conventional patient‐specific QA (psQA). Purpose To demonstrate novel measurement‐based psQA program for UHDR PBS transmission radiotherapy (FLASH‐RT) using high spatiotemporal resolution 2D strip ionization...
Monte Carlo event generators contain a large number of parameters that must be determined by comparing the output generator with experimental data. Generating enough events fixed set parameter values to enable making such comparison is extremely CPU intensive, which prohibits performing simple brute-force grid-based tuning parameters. Bayesian optimization powerful method designed for black-box applications. In this article, we show can accurately obtained using and minimal expert-level...
Abstract Background Quality assurance (QA) for ultra‐high dose rate (UHDR) irradiation is a crucial aspect in the emerging field of FLASH radiotherapy (FLASH‐RT). This innovative treatment approach delivers radiation at UHDR, demanding careful adoption QA protocols and procedures. A comprehensive understanding beam properties dosimetry consistency vital to ensure safe effective delivery FLASH‐RT. Purpose To develop pre‐treatment program cyclotron‐based proton pencil scanning (PBS) Establish...
The GLUEX experiment is located in experimental Hall D at Jefferson Lab (JLab) and provides a unique capability to search for hybrid mesons high-energy photoproduction, utilizing ∼9 GeV linearly polarized photon beam. initial, low-intensity phase of was recently completed high-intensity has begun 2020 which includes an upgraded kaon identification system, known as the DIRC (Detection Internally Reflected Cherenkov light), components from decommissioned BaBar DIRC. final states will...
The GlueX experiment at Jefferson Laboratory aims to perform quantitative tests of non-perturbative QCD by studying the spectrum light-quark mesons and baryons. A Detector Internally Reflected Cherenkov light (DIRC) was installed enhance particle identification (PID) capability providing clean $\pi$/K separation up 3.7 GeV/$c$ momentum in forward region ($\theta<11^{\circ}$), which will allow study hybrid decaying into kaon final states with significantly higher efficiency purity. new PID...
The GlueX experiment takes place in experimental Hall D at Jefferson Lab (JLab). With a linearly polarized photon beam of up to 12 GeV energy, is dedicated search for hybrid mesons via photoproduction reactions. low-intensity (Phase I) was recently completed; the high-intensity II) started 2020 including an upgraded particle identification system, known as DIRC (Detection Internally Reflected Cherenkov light), utilizing components from decommissioned BaBar experiment. and separation kaon...
Click to increase image sizeClick decrease size AcknowledgmentThis research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.