A5058110154- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Sleep and Work-Related Fatigue
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Air Quality and Health Impacts
- Insect and Pesticide Research
- Lipid Membrane Structure and Behavior
- Sleep and related disorders
- Respiratory and Cough-Related Research
- Smoking Behavior and Cessation
- Tryptophan and brain disorders
University of Colorado Anschutz Medical Campus
2024
University of Colorado Denver
2023
Research Triangle Park Foundation
2023
Environmental Protection Agency
2023
Pennsylvania State University
2017-2021
Exposure to social stress is an important risk factor for comorbid affective disorders and problem alcohol use. To better understand mechanisms involved in stress-induced disorder use co-morbidity, we studied the effects of adolescent on anxiety- depression-like behaviors binge-like ethanol consumption. Male female C57BL/6J mice were exposed chronic variable (CVSS) or control conditions throughout adolescence (postnatal days, PND, 25-59) then tested anxiety-like behavior elevated plus maze a...
Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and elements is observed at both excitatory inhibitory synapses, functional significance of this molecular architecture has been challenging to evaluate experimentally. Here we utilized an optogenetic clustering approach acutely alter nanoscale organization scaffold gephyrin...
Spectrum research cigarettes have been developed with varying nicotine content for use in studies evaluating the effects of a regulatory policy reducing permissible cigarettes. This study aimed to characterize pharmacokinetic profile cigarettes.Twelve daily smokers attended four sessions and had blood nicotine, exhaled carbon monoxide, subjective measured before after smoking either single cigarette their preferred brand or high (10.9 mg/cigarette), medium (3.2 low (0.2 mg/cigarette)...
Abstract Experiencing a single severe stressor is sufficient to drive sexually dimorphic psychiatric disease development. The ventral subiculum (vSUB) emerges as site where stress may induce adaptations due its sex-specific organization and pivotal role in integration. Using 1-hr acute restraint model, we uncover that causes net decrease vSUB activity females potent, long-lasting, driven by adrenergic receptor signaling. By contrast, males exhibit increase transient corticosterone We further...
Tools for visualizing and manipulating protein dynamics in living cells are critical understanding cellular function. Here we leverage recently available monoclonal antibody sequences to generate a set of affinity tags labeling AMPA-type glutamate receptors (AMPARs), which mediate nearly all excitatory neurotransmission the central nervous system. These antibodies can be produced from heterologous exogenous applications or directly expressed neurons as intrabodies, where they bind their...
Alcohol use disorder (AUD) is a leading cause of preventable death in the United States, however existing treatments are ineffective and produce aversive side effects such as nausea fatigue. One potential therapeutic for AUD α3β4 nicotinic acetylcholine receptor (nAChR) antagonist 18-methoxycoronaridine (18-MC). Prior work has shown that 18-MC reduces ethanol consumption rodent models. The present study sought to further examine by testing its on nonconsummatory behaviors. We examined 2...
Deaths related to opioid use have skyrocketed in the United States, leading a public health epidemic. Research has shown that both biological (genes) and environmental (stress) precursors are linked use. In particular, stress during adolescence–a critical period of frontal lobe development–influences likelihood abusing drugs. However, little is known about mechanisms through which adolescent leads long-term risk use, or whether genetic background moderates this response. Male female C57BL/6J...
Introduction As a lifestyle factor, poor sleep status is associated with increased cardiovascular morbidity and mortality may be influenced by environmental stressors, including air pollution. Methods To determine whether exposure to pollution modified effects of disruption, we evaluated the single or repeated (twice/wk for 4 wks) inhalation eucalyptus wood smoke (ES; 964 µg/m 3 1 h), key wildland fire source, on mild loss in form gentle handling rats. Blood pressure (BP) radiotelemetry...
1 Abstract Deaths related to opioid use have skyrocketed in the United States, leading a public health epidemic. Research has shown that both biological (genes) and environmental (stress) precursors are linked use. In particular, stress during adolescence – critical period of frontal lobe development influences likelihood abusing drugs. However, little is known about mechanisms through which adolescent leads long-term risk use, or whether genetic background moderates this response. Male...