A5090501947- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Child and Adolescent Health
- Health and Medical Studies
- Immune responses and vaccinations
- Bacterial Infections and Vaccines
- SARS-CoV-2 detection and testing
- Animal Disease Management and Epidemiology
- Genital Health and Disease
- Food Security and Health in Diverse Populations
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
Robert Koch Institute
2015-2025
Centre de Recherche Médicales de Lambaréné
2024
University of Tübingen
2024
Institute of Virology of the Slovak Academy of Sciences
2023
University Hospital Cologne
2023
Ruhr University Bochum
2023
Düsseldorf University Hospital
2023
Heinrich Heine University Düsseldorf
2023
Charité - Universitätsmedizin Berlin
2011-2017
Paul Ehrlich Institut
2016
Herpes zoster (HZ) is caused by a reactivation of the varicella-zoster-virus (VZV) and mainly affects individuals aged≥50 years. Vaccines have been licensed or are under development that can protect against HZ its main complication postherpetic neuralgia (PHN). In Germany, burden disease not well known. To support decision making process related to potential vaccination recommendation, we estimated annual in people years Germany utilizing various data sources.We assessed for 2007 2008...
In Germany, the national routine childhood immunization schedule comprises 12 vaccinations. Primary immunizations should be completed by 24 mo of age. However, nationwide monitoring vaccination coverage (VC) is performed only at school entry. We utilized health insurance claims data covering ~85% total population with objectives to (1) assess VC all recommended vaccinations in birth-cohorts 2004–2009, (2) analyze cross-sectional (at and 36 mo) longitudinal trends, (3) validate method...
In Germany, routine childhood varicella vaccination was implemented in 2004 with two doses recommended since 2009. We used an immunisation information system based on countrywide health insurance claims data to analyse vaccine effectiveness (VE) and factors influencing VE. applied proportional hazard models estimate VE under various conditions compared the risk of acquiring among unvaccinated children regions high vs low coverage (VC). Among 1.4 million we identified 29,404 cases over a...
In Germany, whole-cell pertussis vaccines were rapidly replaced by high-concentration acellular pertussis-containing (3+1 doses from 2 months of age) starting in 1995. Boosters recommended for 9- to 17-year-olds (2000) and 5- 6-year-olds (2006). Pertussis incidence remains high despite rising vaccination coverage (VC). Therefore, we analyzed VC vaccine effectiveness (VE) the federal state Brandenburg.In a stratified case-cohort analysis, compared reported cases with assessed schools...
Influenza and pneumococcal vaccination can prevent disease potentially life-threatening complications like sepsis. Elderly people have an increased risk of severe therefore constitute a major target group for vaccination. To increase coverage, targeted interventions are needed that take theory-based specific determinants behaviour into account. Moreover, message campaign design should consider age-related characteristics (e.g., information processing, media use). The aim this study is (i) to...
We aimed to quantify progress towards measles elimination in Germany from 2007 2011 and estimate any potential underreporting over this period.We determined the annual incidence of notified cases - for each year northern, western, eastern southern across whole country. then used measles-related health insurance claims corresponding incidence.In between 2011, there were 6.9-19.6 (mean: 10.8) per million population. Incidence decreased with age showed geographical variation, highest mean 20.3...
Germany has a well established broad statutory surveillance system for infectious diseases. In the context of current outbreak bloody diarrhoea and haemolytic uraemic syndrome caused by Shiga toxin/ verotoxin-producing Escherichia coli in it became clear that provisions routine were not sufficient an adequate response. This article describes timeline concepts enhanced implemented during this public health emergency.
Immunisation registers are regarded as an appropriate solution to measure vaccination coverage on a population level. In Germany, decentralised healthcare system and data protection regulations constrain such approach. Moreover, shared responsibilities in the process of immunisation multiple providers form framework for public health interventions issues. On national level, those consist mainly conceptualising strategies, establishing programmes, issuing recommendations. This paper provides...
In Germany, mumps has been notifiable until 2013 only in the five Eastern federal states (EFS) of former East Germany. Due to different immunisation policies 1990 and varying vaccination coverages thereafter, incidences cannot be extrapolated 11 Western (WFS). We studied mumps-related International Classification Diseases (ICD-10) code diagnoses claimed through statutory health insurances between 2007 2011 estimate countrywide outpatient sector, compared them with case numbers from...
Anaphylaxis is a life-threatening event. The aim of this study was to estimate the annual frequency anaphylaxis after immunization in individuals younger than 18 years Germany leading hospitalization.All suspected cases postvaccination involving aged 0-17 reported German surveillance unit for rare pediatric diseases (Erhebungseinheit für seltene pädiatrische Erkrankungen Deutschland) from June 2008 through May 2010, and all as an adverse event following same age group Paul-Ehrlich-Institut...
ObjectivesTo describe the characteristics of a large hepatitis A virus (HAV) outbreak among men who have sex with (MSM) in Berlin and to assess impact measures implemented.MethodsCases laboratory-confirmed, symptomatic HAV infection notified Berlin, Germany between August 2016 February 2018 were analysed using routine enhanced surveillance data including genotyping results. Several studies involving different groups participants conducted further investigate outbreak, surveys on knowledge...
Elderly people are at increased risk for severe influenza illness and constitute therefore a major target-group seasonal vaccination in most industrialized countries. The aim of this study was to estimate vaccine effectiveness (VE) among individuals aged 60+ years over three seasons assess if the screening method is suitable tool monitor VE particular Germany.We identified laboratory-confirmed cases through national communicable disease reporting system 2010/11, 2011/12 2012/13. Vaccination...
Background Sepsis is a life-threatening organ dysfunction due to dysregulated host response infection. Annually, sepsis leads approx. 90.000 deaths in Germany. Risk factors include amongst others older age (>60), innate or acquired of the immune system, and underlying chronic diseases lung, heart, liver, kidneys. The manifestation medical emergency, patient outcomes depend on timely diagnosis immediate treatment. In addition, vaccinations e.g., against pneumococci influenza virus, are...
ABSTRACT Malaria rapid diagnostic tests (RDTs), which detect Plasmodium falciparum (Pf)-specific histidine-rich protein-2 (HRP2), have increasing importance for the diagnosis and control of malaria, especially also in regions where routine by microscopy is not available. HRP2-based RDTs a similar sensitivity to expert microscopy, but their reported low specificity can lead high false positivity rates, particularly high-endemic areas. Despite widespread use RDTs, models investigating dynamics...
Background Guillain-Barré syndrome (GBS) has been associated with vaccination against COVID-19. Aim We aimed to compare clinical characteristics and analyse excess GBS cases following administration of different COVID-19 influenza vaccines in Germany versus the expected numbers estimated from pre-pandemic background incidence rates. Methods analysed safety surveillance data reported German national competent authority between 27 December 2020 31 August 2021. were validated according Brighton...