A5010924940- Vaccine Coverage and Hesitancy
- Antibiotic Use and Resistance
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune responses and vaccinations
- Pediatric Urology and Nephrology Studies
- Herpesvirus Infections and Treatments
- COVID-19 diagnosis using AI
- Hepatitis Viruses Studies and Epidemiology
- Microbial infections and disease research
- Antibiotics Pharmacokinetics and Efficacy
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Reproductive tract infections research
Robert Koch Institute
2013-2025
Charité - Universitätsmedizin Berlin
2010
Data on microbiological profiles in odontogenic infections are scarce. This study aimed to analyze the spectrum of pathogens and antimicrobial resistance clinical isolates from dental oral-maxillofacial settings Germany. We analyzed 20,645 (dental practices: n = 5,733; hospitals: 14,912) patients with using data (2012–2019) German Antimicrobial-Resistance-Surveillance (ARS) system. A total 224 different species 73 genera were found practices, 329 97 identified hospital patients. In both...
In Germany, the national routine childhood immunization schedule comprises 12 vaccinations. Primary immunizations should be completed by 24 mo of age. However, nationwide monitoring vaccination coverage (VC) is performed only at school entry. We utilized health insurance claims data covering ~85% total population with objectives to (1) assess VC all recommended vaccinations in birth-cohorts 2004–2009, (2) analyze cross-sectional (at and 36 mo) longitudinal trends, (3) validate method...
Recent analysis of trends non-invasive infections with methicillin resistant Staphylococcus aureus (MRSA), MRSA in outpatient settings and co-resistance profiles isolates are scarce or lacking Germany.We analysed data from the Antimicrobial Resistance Surveillance Network (ARS). We included first isolate S. per patient year, which had a valid test result for oxacillin resistance was not screening sample. limited to facilities, contributed ARS all six years between 2010 2015. compared...
Abstract Background Carbapenem-resistant Gram-negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are among WHO’s priority pathogens with antimicrobial resistance (AMR). Studies suggest potential impacts of the COVID-19-pandemic on AMR. We described changes in AMR incidence epidemiology Germany during COVID-19-pandemic. Methods used two independent datasets, statutory surveillance laboratory-based Antibiotic Resistance Surveillance (ARS). included notifications...
Background: Antimicrobial consumption (AMC) patterns, besides prescribing behaviors, reflect the changing epidemiology of infectious diseases. Routine surveillance data have been used to investigate development AMC from 2017 2023 and impact COVID-19 within context framing time periods. Methods: Data 112 hospitals, continuously participating in national system hospital antimicrobial based at Robert Koch Institute, were analyzed according WHO ATC (Anatomical Therapeutic Chemical)/DDD (Defined...
Routine urine culture testing is not recommended for uncomplicated urinary tract infections (UTIs). As a result, the antibiotic resistance patterns or organisms causing UTIs are adequately reflected in routine data. We studied sensitivity of Escherichia coli (E. coli) to trimethoprim (TMP) and cotrimoxazole (i.e., trimethoprim/sulfamethoxazole, TMP/SMX) community-acquired UTI compared findings with data Antimicrobial Resistance Surveillance System (ARS).
Abstract Background Carbapenem resistance in Klebsiella pneumoniae is of significant public health concern and recently spread across several countries. We investigated the extent carbapenem non-susceptibility K. isolates Germany. Methods analysed 2011–2016 data from German Antimicrobial Resistance Surveillance (ARS) System, which contains routine antimicrobial susceptibility testing voluntarily participating laboratories. tested resistant or intermediate against an antibiotic were...
In Germany, routine childhood varicella vaccination was implemented in 2004 with two doses recommended since 2009. We used an immunisation information system based on countrywide health insurance claims data to analyse vaccine effectiveness (VE) and factors influencing VE. applied proportional hazard models estimate VE under various conditions compared the risk of acquiring among unvaccinated children regions high vs low coverage (VC). Among 1.4 million we identified 29,404 cases over a...
The features of a newly established, web-based surveillance system for hospital antibiotic consumption are described and data on broad-spectrum use in German acute care hospitals presented.The watch- reserve-group antibiotics, two categories antibiotics derived from the WHO Essential Medicines List comprising key agents antimicrobial stewardship, were used as framework analysis. median densities (ACDs; DDD/100 patient days) years 2015/16 based 137 have been calculated whole facilities, ICUs...
The German Standing Committee on Vaccination recommends annual vaccination for persons in high-risk groups order to lower the disease burden associated with seasonal influenza. stated target is 75% coverage of people over age 60 by year 2010. We present statistics based billing data associations statutory health insurance physicians regarding influenza three seasons from 2004/05 2006/07.We analyzed anonymous 14 17 Germany. study population consisted all covered geographical areas under (61.5...
Since July 2004, routine varicella vaccination is recommended by the German Standing Vaccination Committee in Germany. Health Insurance Funds started to cover costs at different time points between 2004 and 2006 Federal States. Nationwide representative data on coverage against of children under two years age are not available. We aimed determine statutory health insured twelve States using from associations insurance physicians (ASHIPs), order investigate acceptance programme.We analysed 13...
Eliminating measles in Europe by 2015 is a WHO health goal. In Germany, physicians are legally required to report cases, yet it seems likely that reporting less than universal. The goal of this study compare the number cases reflected data from statutory insurance (SHI) carriers with physician-reported during and after recent outbreak German state North Rhine-Westphalia (NRW).We analyzed billing SHI relating 2006 2007, as well were reported NRW over period law. We calculated incidence per...
Recent findings on Antibiotic Resistance (AR) have brought renewed attention to the comparison of data AR from human and animal sectors. This is however a major challenge since not harmonized. study performs comparative analysis resistance combinations in Escherichia coli ( E . ) different routine surveillance monitoring systems for populations Germany. Data isolates were collected between 2014 2017 clinical isolates, non-clinical food-producing animals food, companion national Sixteen...
During the autumn wave of pandemic influenza virus A/(H1N1) 2009 (pIV) German population was offered an AS03-adjuvanted vaccine. The authors compared results two methods calculating effectiveness vaccine (VE). test-negative case-control method used data from virologic surveillance including influenza-positive and negative patients. An innovative case-series methodology explored all nationally reported laboratory-confirmed cases. proportion cases occurring in vaccinees during assumed...
Hintergrund: Im Rahmen des KV-Sentinels, einem gemeinsamen Projekt Robert Koch-Instituts und der 17 Kassenärztlichen Vereinigungen, werden seit 2004 pseudonymisierte Abrechnungsdaten von den Vereinigungen an das Koch-Institut übermittelt. Ziel Beitrages ist es zu beschreiben, mit welchen methodischen Verfahren die Daten aufbereitet werden, um Impfquoten Inzidenzen impfpräventablen Erkrankungen bestimmen. Weiterhin wird diskutiert, welche Limitationen bei Interpretation beachten sind.
In Germany, there is an increasing amount of vancomycin-resistant Enterococcus faecium (VREfm) isolates in bloodstream infections (BSIs); however, estimates on recent incidences and disease burden are missing. We aim to estimate the incidence calculate annual disease-adjusted life years (DALYs) for BSIs due VREfm Germany between 2015 2020 support informed decision-making field antimicrobial resistance (AMR). used Antibiotic Resistance Surveillance (ARS) system data obtain estimates. The...