A5054711300- Immune cells in cancer
- Inflammation biomarkers and pathways
- Macrophage Migration Inhibitory Factor
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Protease and Inhibitor Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- Glutathione Transferases and Polymorphisms
- Occupational and environmental lung diseases
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- IL-33, ST2, and ILC Pathways
- Phagocytosis and Immune Regulation
- Bladder and Urothelial Cancer Treatments
- Long-Term Effects of COVID-19
Institute for Basic Science
2024
Wuhan University
2018-2022
Renmin Hospital of Wuhan University
2018-2022
Children's Hospital of Chongqing Medical University
2021
Chongqing Medical University
2021
China Pharmaceutical University
2021
University of Alabama at Birmingham
2006-2014
Fudan University
2012
Cleveland Clinic
2009
Matrix stiffening and myofibroblast resistance to apoptosis are cardinal features of chronic fibrotic diseases involving diverse organ systems. The interactions between altered tissue biomechanics cellular signaling that sustain progressive fibrosis not well defined. In this study, we used ex vivo in approaches define a mechanotransduction pathway Rho/Rho kinase (Rho/ROCK), actin cytoskeletal remodeling, mechanosensitive transcription factor, megakaryoblastic leukemia 1 (MKL1), coordinately...
Abstract Chemoresistance due to heterogeneity of the tumor microenvironment (TME) hampers long-term efficacy first-line therapies for lung cancer. Current combination cancer provide only modest improvement in survival, implicating necessity novel approaches that suppress malignant growth and stimulate antitumor immunity. Oxidative stress TME promotes immunosuppression by tumor-infiltrating myeloid-derived suppressor cells (MDSC), which inhibit host protective Using a murine model cancer, we...
To investigate the effects and underlying molecular mechanisms of FoxG1 expression on glioblastoma multiforme (GBM) models. Expression levels other cancer-related biomarkers were evaluated by qRT-PCR, immunoblotting immunohistochemistry. Crystal violet staining MTT assay applied in this study to verify cell proliferation ability viability GBM models with/without drug treatment. Immunohistochemical qRT-PCR assays showed that endogenous positively correlated disease progression. Overexpression...
Tumors are closely related to the tumor microenvironment (TME). The complex interaction between cells and TME plays an indisputable role in development. Tumor can affect TME, promote angiogenesis induce immune tolerance by releasing cell signaling molecules. Immune infiltration (ICI) prognosis of patients with bladder cancer. However, pattern ICI cancer has not yet been elucidated. Herein, we identified three distinct subtypes based on 584 using ESTIMATE CIBERSORT algorithms. Then, gene...
Fibroblasts from patients with pulmonary fibrosis express higher levels of the receptor for urokinase, and extent in some animal models exhibits a dependence on urokinase receptor. Recent observations have identified as trans-interacting consequences signaling cell responses that vary depending its interacting partner, relative expression, state cellular transformation. We undertook this study to define urokinase-type plasminogen activator (u-PAR)-integrin interactions determine functional...
Recent research has identified that miR-539-3p impedes chondrogenic differentiation, yet its specific role and underlying mechanisms in childhood-onset osteoarthritis (OA) remain unclear. This study found levels were considerably lower cartilage samples derived from OA patients compared to the control group. Enhancing expression or suppressing RUNX2 notably reduced apoptosis, inflammation, extracellular matrix (ECM) degradation chondrocytes. In contrast, reducing increasing had opposite...
Background OTUB1 is a member of OTUs (Ovarian-tumor-domain-containing proteases), deubiquitinating enzymes family (DUBs), which was shown as proteasome-associated DUB to be involved in the proteins Ub-dependent degradation. It has been reported that expressed kidney tissue. But its concrete cellular location and function remain unclear. Decorin (DCN) mesangial cells (MC) considered potentially important factor for antagonizing glomerulonephritides, degradation mediated by ubiquitination. The...
<title>Abstract</title> Somatostatin-expressing (SST) interneurons modulate hemodynamic responses both directly and indirectly, but their precise role remains unclear. Here, we investigated how SST affect hemodynamics using a combination of electrophysiology, intrinsic optical imaging, calcium fMRI with pharmacological, optogenetic, chemogenetic manipulations. Prolonged optogenetic stimulation neurons induces fast vasodilation through nitric oxide synthase-expressing that co-express SST,...
Tumour immunotherapy combined with molecular typing is a new therapy to help select patients. However, algorithms related tumour immune function have not been thoroughly explored. We herein proposed single sample signature network (SING) method identify function-related subtypes of cutaneous melanoma the skin. A sample-specific and microenvironment were constructed based on annotation samples. Then, differences heterogeneity among different analysed verified. total 327 cases divided into...
To detect the expression of miR-4719 in breast cancer tissues and cells explore its role regulating invasion migration cells.qRT-PCR was used to ARHGAP36 30 pairs human adjacent tissues, two cell lines (BT549 MDA-MB- 231) normal (MCF-10A). Bioinformatic methods were utilized analyze relationship between overall survival patients predict potential target gene miR- 4719. mimics, shRNA plasmids transfected into test effects overexpression, knockdown overexpression on using wound healing assay...
Abstract Heterogeneity and immunosuppression in the tumor microenvironment (TME) has dampened efficacy of current frontline combination chemotherapies for lung cancer which provided limited improvement patient survival. Modified amino acid metabolism TME contributes to progression suppression anti-tumor immunity. Enhanced tryptophan primary patients is indicative advanced disease stage. One key regulators an intracellular, heme-containing enzyme indoleamine 2,3-dioxygenase (IDO). IDO...
<p>PDF file - 31K, Description of additional methods and procedures used in the study.</p>
<p>PDF file - 381K, The phenotype of MDSC in the lung and spleen from cancer challenged mice (S1); Reduced tumor burden Gem SODmim+Gem therapy groups (S2); Combination reduced infiltration neutrophils but not macrophages (S3); was efficient reducing growth catalase deficient by decreasing improving memory CD8+ T cell response (S4); Persistent subsets expand following re-encounter with i.v. LLC cells (S5); Adoptively transferred persist reduce LLC-rechallenged recipient (S6); upon...
<div>Abstract<p>Chemoresistance due to heterogeneity of the tumor microenvironment (TME) hampers long-term efficacy first-line therapies for lung cancer. Current combination cancer provide only modest improvement in survival, implicating necessity novel approaches that suppress malignant growth and stimulate antitumor immunity. Oxidative stress TME promotes immunosuppression by tumor-infiltrating myeloid-derived suppressor cells (MDSC), which inhibit host protective Using a...
<div>Abstract<p>Chemoresistance due to heterogeneity of the tumor microenvironment (TME) hampers long-term efficacy first-line therapies for lung cancer. Current combination cancer provide only modest improvement in survival, implicating necessity novel approaches that suppress malignant growth and stimulate antitumor immunity. Oxidative stress TME promotes immunosuppression by tumor-infiltrating myeloid-derived suppressor cells (MDSC), which inhibit host protective Using a...
Immunosuppression in the tumor microenvironment (TME) has dampened efficacy of current front line combination chemotherapies for lung cancer thus providing limited improvement patient survival. Myeloid Derived Suppressor Cells (MDSCs) are major contributors immunosuppression by producing Reactive Oxygen Species (ROS) and modulating amino acid metabolism TME. Indoleamine 2,3‐dioxygenase (IDO) is an intracellular enzyme that a key regulator tryptophan involved immunosuppression. We have...
<p>PDF file - 381K, The phenotype of MDSC in the lung and spleen from cancer challenged mice (S1); Reduced tumor burden Gem SODmim+Gem therapy groups (S2); Combination reduced infiltration neutrophils but not macrophages (S3); was efficient reducing growth catalase deficient by decreasing improving memory CD8+ T cell response (S4); Persistent subsets expand following re-encounter with i.v. LLC cells (S5); Adoptively transferred persist reduce LLC-rechallenged recipient (S6); upon...
<p>PDF file - 31K, Description of additional methods and procedures used in the study.</p>