A5066325337- Gout, Hyperuricemia, Uric Acid
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Extracellular vesicles in disease
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Mesenchymal stem cell research
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Pericarditis and Cardiac Tamponade
- Rheumatoid Arthritis Research and Therapies
- Cardiac Arrest and Resuscitation
- Alcoholism and Thiamine Deficiency
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Sepsis Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Acute Kidney Injury Research
- Cardiovascular Effects of Exercise
- Veterinary medicine and infectious diseases
- Systemic Sclerosis and Related Diseases
Sichuan University
2019-2024
Chengdu Fifth People's Hospital
2020-2024
Chengdu University of Traditional Chinese Medicine
2022
West China Hospital of Sichuan University
2019-2021
Affiliated Hospital of North Sichuan Medical College
2013
Background The toll-like receptor (TLR)4-interleukin1β (IL1β) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation. aim of this present study was to determine whether TLR4 gene rs2149356 SNP associated with gouty arthritis (GA) susceptibility and impacts TLR4-IL1β molecules expression. Methods Findings detected 459 GA patients 669 control subjects (containing healthy 210 hyperuricemic subjects). Peripheral blood mononuclear cells (PBMCs) mRNA serum IL1β were...
Abstract Background In patients with hypertrophic cardiomyopathy (HCM), ischemic myocardial fibrosis assessed by late gadolinium enhancement (I-LGE) using cardiovascular magnetic resonance (CMR) have been reported. However, the clinical significance of I-LGE has not completely understood. We aim to evaluate differ phenotypically from HCM without LGE or nonischemic (NI-LGE) in left ventricle (LV). Methods The whom was underwent CMR were enrolled, cine cardiac LV function and detect fibrosis....
To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) to elucidate possible causes death in mice receiving high-dose MVs.
Objective Pleural effusion (PE) is a common pulmonary manifestation in patients with systemic lupus erythematosus (SLE), and associated disease activity. However, little known regarding the additive effects of PE on cardiac function. Therefore, this study aimed to investigate multi-parameter cardiovascular magnetic resonance imaging (CMR) findings SLE explore whether involvement PE. Methods Patients age-matched/sex-matched healthy controls were included study. diagnosed according 2019...
Objective To investigate the role of microRNA(miR)-23a-27a-24-2 cluster in patho-genesis primary gout arthritis. Methods The subjects were divided into two groups: 55 acute patients (AG), and 35 healthy controls (HC). Clinical laboratory parameters collected. The expression level miR-23a, miR-24-2, miR-27a was detected using real-time fluorescent quantitative polymerase chain reaction (PCR) (TaqMan probe). PBMCs HC stimulated with 100 μg/ml for 12 h to intimate inflammatory...
Objective To investigate the differential expression levels of ELOVL6 mRNA and protein in peripheral blood mononuclear cells (PBMCs) patients with GA control population, clarify relationship between gene pathological mechanisms disease. Methods ① Two hundreds seventy-four GA(158 AGA, 116 NAGA) 112 healthy controls (HC) were enrolled into study. The clinical data primary gouty arthritis collected. PBMCs isolated from vitro. ② expressions measured by Real-time polymerase chain reaction...
Objective To investigate the mRNA and protein expression levels of telomeric-repeat binding factor-1 (TRF1) TRF2 in peripheral blood mononuclear cells (PBMCs) patients with systemic lupus erythematosus (SLE), relations between these gene clinical data SLE were explored. Methods According to disease activity, divided into active group (40 cases) stable (67 cases). These also grouped as renal damage (46 damage-free (61 based on their conditions. Healthy individuals (41 included control....