A5065733317- Cervical Cancer and HPV Research
- Reproductive tract infections research
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Genital Health and Disease
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunotherapy and Immune Responses
- Adolescent Sexual and Reproductive Health
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Genetic and phenotypic traits in livestock
- Monoclonal and Polyclonal Antibodies Research
- Reproductive Physiology in Livestock
- Urinary Tract Infections Management
- Animal Genetics and Reproduction
- Escherichia coli research studies
- Menstrual Health and Disorders
- Sexual Differentiation and Disorders
- Physiological and biochemical adaptations
- Genetic factors in colorectal cancer
- Allergic Rhinitis and Sensitization
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Parasitic Infections and Diagnostics
- Chromosomal and Genetic Variations
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2020-2025
Université de Montpellier
2013-2025
Institut de Recherche pour le Développement
2014-2025
Centre National de la Recherche Scientifique
2014-2025
Inserm
2003-2024
GenVec
2024
Institut de Génomique Fonctionnelle
2024
Centre Hospitalier Universitaire de Montpellier
2021-2022
Agropolis International
2021
Hôpital Arnaud de Villeneuve
2003-2017
In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis SOX9-bound chromatin regions from murine and bovine foetal testes with sequencing RNA samples mouse lacking Sox9. We found controls a conserved programme involves most sex-determining genes. testes, modulates both transcription or indirectly sex-specific differential splicing its target...
Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV are cleared less than two years, but the underlying mechanisms that favour persistence around 10% of women remain largely unknown. Notwithstanding, it is precisely this information crucial for improving treatment, screening, and vaccination strategies. To understand viral immune dynamics non-persisting infections, we set up an observational longitudinal...
The vaginal microbiota is known to affect women's health. Yet, there a notable paucity of high-resolution follow-up studies lasting several months, which would be required interrogate the long-term dynamics and associations with demographic behavioural covariates. Here, we present longitudinal cohort study 125 women, followed for median duration 8.6 11 samples collected per woman. Using hierarchical Bayesian Markov model, characterised patterns community persistence transition,...
All therian mammals have a similar XY/XX sex-determination system except for dozen species. The African pygmy mouse, Mus minutoides, harbors an unconventional in which all males are XY, and there three types of females: the usual XX but also XX* X*Y ones (the asterisk designates sex-reversal mutation on X chromosome). long-term evolution such is paradox, because females expected to face high reproductive costs (e.g., meiotic disruption loss unviable YY embryos), should prevent invasion...
Introduction Human papillomaviruses (HPVs) are responsible for one-third of all cancers caused by infections. Most HPV studies focus on chronic infections and cancers, we know little about the early stages infection. Our main objective is to better understand course natural history cervical in healthy, unvaccinated vaccinated, young women, characterising dynamics various infection-related populations (virus, epithelial cells, vaginal microbiota immune effectors). Another analyse diversity...
<i>Background:</i> Results from a transcriptome analysis of human CD4+ T regulatory type 1 (Tr1) clones have indicated that transcripts for the integrins CD18 and CD49b are overexpressed in these cells. The aim this study was to investigate whether presence cells concomitantly expressing molecules could be detected asthmatic patients represent Tr1 <i>Methods:</i>Expression analyzed by flow cytometry on peripheral blood mononuclear various severity healthy subjects....
The African pygmy mouse Mus minutoides is characterized by the presence of a high proportion fertile XY females in natural populations. This species displays 2 morphologically different X chromosomes: ancestral and shorter one designated as X*, feminizing X*Y individuals. strongly suggests that an X* chromosome, male differentiation program not activated despite functional Y chromosome. In this study, we compared histology adult ovaries 3 female genotypes (XX, XX* X*Y) investigated...
Abstract The vaginal microbiota is categorised into five main community state types (CST) that are known to affect women’s health. Yet, there a notable paucity of high-resolution follow-up studies lasting several months, which required interrogate the long-term dynamics and associations with demographic behavioural covariates. Here, we present longitudinal cohort 125 women followed for median duration 8.6 providing 11 samples per woman. Using hierarchical Bayesian Markov model, characterised...
Background We studied the duration of HPV detection and risk (re-) for 25 genotypes in a cohort 132 women followed every eight weeks up to two years between 2016 2020. Participants were 18 old at inclusion half them vaccinated against HPV. They recruited near University STI centre Montpellier, France.
The SecA2 auxiliary secretion system of Gram-positive bacteria promotes the export virulence proteins essential for colonization host in case both Mycobacterium tuberculosis and Listeria monocytogenes, two intracellular causing diseases humans. We others have demonstrated that this is also linked to onset long-term CD8(+) T cell-mediated protective immunity mice. In L. expression inside cytosol infected cells correlates with generation CCL3-secreting memory are required protection against...
Inducing long-term protective memory CD8+ T-cells is a desirable goal for vaccines against intracellular pathogens. However, the mechanisms of differentiation into long-lived cells capable mediating protection immunized hosts remain incompletely understood. We have developed an experimental system using mice with wild type (WT) or mutants bacterium Listeria monocytogenes (Lm) that either do not develop T-cells. previously reported Lm lacking functional SecA2, auxiliary secretion...
The vaginal ecosystem is a key component of women's health. It also represents an ideal system for ecologists to investigate the consequence perturbations on species diversity and emerging properties between organizational levels. Here, we study how exposure different types menstrual products linked microbial, immunological, demographic, behavioural measurements in cohort young adult women who reported using more often tampons (n = 107) or cups 31). We first found that cup users were older...
Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory 1 (Tr1) cells, relative contribution either subset UV radiation-induced immunosuppression not been established. Here, we show isolated from non-treated allergic contact dermatitis (ACD) reactions, 48 h following nickel challenge...
Human papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of latter in cervical cancer is controversial but its long-term infections might modulate mucosal microenvironment a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, studying immunological microbiological dynamics early stages these may help identify or rule out potential interactions. report two...
Abstract Human papillomaviruses (HPVs) are the most oncogenic viruses known to humans, with 12 high-risk (HR) genotypes causing nearly all cervical cancers. Cytology is commonly used screen for lesions but currently being replaced by testing HPV (HR HPV). Although HR screening has a higher sensitivity, its specificity limited, and it advised repeat first 4 6 months later. To increase sensitivity of triage, other biomarkers have been suggested, including viral load. Indeed, since 1999,...
Human papillomavirus (HPV) infections drive one in twenty new cancer cases. Despite the potential for improving treatment, screening, and vaccination strategies, little is known as to why most HPV clear spontaneously within two years. To untangle dynamics of these non-persisting infections, we performed a combined quantitative analysis virological, immunological, clinical data from an original longitudinal cohort 189 women with high temporal resolution. We find that viral load reaches...
Abstract Understanding genital infections by Human papillomaviruses (HPVs) remains a major public health issue, especially in countries where vaccine uptake is low. We investigate HPV prevalence and antibody status 150 women (ages 18 to 25) Montpellier, France. At inclusion one month later, cervical swabs, blood samples questionnaires (for demographics behavioural variables) were collected. Oncogenic, non-vaccine genotypes HPV51, HPV66, HPV53, HPV52 the most frequently detected viral...
Abstract Human papillomaviruses (HPVs) are the most oncogenic viruses known to human, causing nearly all cervical cancers worldwide. Highly prevalent in young, sexually active women, HPV infections cleared within 3 years, and only a minority of those persist lead cancer later life. To better characterize immuno-modulatory impact early infection more generally perturbations cervicovaginal milieu, we measured changes panel 20 cytokines, as highly dynamic effector molecules implicated cell...