A5019174091- COVID-19 epidemiological studies
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Reproductive tract infections research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- Mathematical and Theoretical Epidemiology and Ecology Models
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- interferon and immune responses
- Adolescent Sexual and Reproductive Health
- Viral Infections and Immunology Research
- Mental Health Research Topics
- Genital Health and Disease
- Influenza Virus Research Studies
- Inflammatory Bowel Disease
- Vaccine Coverage and Hesitancy
- Celiac Disease Research and Management
- Infection Control and Ventilation
- Complex Systems and Time Series Analysis
- Viral Infections and Outbreaks Research
- Microscopic Colitis
- Menstrual Health and Disorders
- HIV/AIDS drug development and treatment
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2019-2025
Université de Montpellier
2020-2025
Institut de Recherche pour le Développement
2020-2025
Centre National de la Recherche Scientifique
2020-2025
Swiss Tropical and Public Health Institute
2021-2025
Agropolis International
2021-2022
Leeds Teaching Hospitals NHS Trust
2021
Centre Hospitalier Universitaire de Montpellier
2021
Institute for Disease Modeling
2016-2019
Bellevue Hospital Center
2016-2019
Abstract The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden daily adherence have not yet been developed. Here we describe an oral dosage form composed distinct drug–polymer matrices which achieved week-long systemic drug levels antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations viral dynamics patient patterns indicate such would reduce therapeutic failures...
Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV are cleared less than two years, but the underlying mechanisms that favour persistence around 10% of women remain largely unknown. Notwithstanding, it is precisely this information crucial for improving treatment, screening, and vaccination strategies. To understand viral immune dynamics non-persisting infections, we set up an observational longitudinal...
SARS-CoV-2 virus has spread over the world rapidly creating one of largest pandemics ever. The absence immunity, presymptomatic transmission, and relatively high level virulence COVID-19 infection led to a massive flow patients in intensive care units (ICU). This unprecedented situation calls for rapid accurate mathematical models best inform public health policies. We develop an original parsimonious discrete-time model that accounts effect age on natural history disease. Analysing ongoing...
The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is reminder zoonotic and pathogenic potential emerging coronaviruses humans. Clinical features respiratory syndrome (MERS) include atypical pneumonia progressive failure that highly reminiscent severe acute (SARS) caused by SARS-CoV. host response key component virus infection. Here, we computationally analyzed gene expression changes human airway epithelial cell line infected with two genetically distinct...
Variants of severe acute respiratory syndrome coronavirus 2 raise concerns regarding the control disease epidemics. We analyzed 40,000 specific reverse transcription PCR tests performed on positive samples during January 26-February 16, 2021, in France. found high transmission advantage variants and more advanced spread than anticipated.
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ABSTRACT The 1918-1919 influenza pandemic remains the single greatest infectious disease outbreak in past century. Mouse and nonhuman primate infection models have shown that 1918 virus induces overly aggressive innate proinflammatory responses. To understand response to viral role of individual genes on host virus, we examined reassortant avian viruses nearly identical (1918-like virus) carrying either hemagglutinin (HA) or PB2 gene. In mice, both enhanced 1918-like replication, but only...
The oral polio vaccine (OPV) contains live-attenuated polioviruses that induce immunity by causing low virulence infections in recipients and their close contacts. Widespread immunization with OPV has reduced the annual global burden of paralytic poliomyelitis a factor 10,000 or more driven wild poliovirus (WPV) to brink eradication. However, instances have so far been rare, can paralyze generate vaccine-derived outbreaks. To complete eradication, use should eventually cease, but doing will...
Abstract SARS-Cov-2 virus has spread over the world creating one of fastest pandemics ever. The absence immunity, asymptomatic transmission, and relatively high level virulence COVID-19 infection it causes led to a massive flow patients in intensive care units (ICU). This unprecedented situation calls for rapid accurate mathematical models best inform public health policies. We develop an original parsimonious model that accounts effect age on natural history disease. Analysing ongoing...
Introduction Human papillomaviruses (HPVs) are responsible for one-third of all cancers caused by infections. Most HPV studies focus on chronic infections and cancers, we know little about the early stages infection. Our main objective is to better understand course natural history cervical in healthy, unvaccinated vaccinated, young women, characterising dynamics various infection-related populations (virus, epithelial cells, vaginal microbiota immune effectors). Another analyse diversity...
BackgroundThe COVID-19 pandemic has led to an unprecedented daily use of RT-PCR tests. These tests are interpreted qualitatively for diagnosis, and the relevance test result intensity, i.e. number quantification cycles (Cq), is debated because strong potential biases.AimWe explored possibility Cq values from SARS-CoV-2 screening better understand spread epidemic biology infection.MethodsWe used linear regression models analyse a large database 793,479 performed on more than 2 million samples...
The Covid-19 pandemic outbreak was followed by a huge amount of modelling studies in order to rapidly gain insights implement the best public health policies. Most these compartmental models involved ordinary differential equations (ODEs) systems. Such formalism implicitly assumes that time spent each compartment does not depend on already it, which is at odds with clinical data. To overcome this “memoryless” issue, widely used solution increase and chain number compartments unique reality (...
There is known heterogeneity between individuals in infectious disease transmission patterns. The source of this thought to affect epidemiological dynamics but studies tend not control for the overall number secondary cases caused by an infection. To explore role individual variation infection duration and rate parasite emergence spread, while controlling potential bias, we simulate stochastic outbreaks with without evolution. As expected, decreases probability outbreak emergence....
RV144 is to date the only HIV vaccine trial demonstrate efficacy, albeit rapidly waning over time. The HVTN 702 currently evaluating in South Africa a similar formulation that of for subtype C with additional boosters (pox-protein regimen). Using detailed stochastic individual-based network model disease transmission calibrated epidemic, we investigate population-level impact and maximum cost an remain cost-effective.Consistent original pox-protein regimen, primary series five vaccinations...
Abstract The vaginal microbiota is categorised into five main community state types (CST) that are known to affect women’s health. Yet, there a notable paucity of high-resolution follow-up studies lasting several months, which required interrogate the long-term dynamics and associations with demographic behavioural covariates. Here, we present longitudinal cohort 125 women followed for median duration 8.6 providing 11 samples per woman. Using hierarchical Bayesian Markov model, characterised...
ABSTRACT Using whole-blood transcriptional profiling, we investigated differences in the host response to vaccination and challenge a rhesus macaque AIDS vaccine trial. Samples were collected from animals prior after with live, irradiated cells secreting modified endoplasmic reticulum chaperone gp96-Ig loaded simian immunodeficiency virus (SIV) peptides, either alone or combination SIV-gp120 protein boost. Additional samples following multiple low-dose rectal challenges SIV mac251 . Animals...
Highlights•We produce novel human contact network analytics for the COVID-19 pandemic.•We use these time series models of French hospital incidence.•National-level predictions are greatly improved by adding analytics.•Subnational analyses reveal spatial correlations incidence.AbstractBackground was first detected in Wuhan, China, 2019 and spread worldwide within a few weeks. The epidemic started to gain traction France March 2020. Subnational admissions deaths were then recorded daily served...
The vaginal ecosystem is a key component of women's health. It also represents an ideal system for ecologists to investigate the consequence perturbations on species diversity and emerging properties between organizational levels. Here, we study how exposure different types menstrual products linked microbial, immunological, demographic, behavioural measurements in cohort young adult women who reported using more often tampons (n = 107) or cups 31). We first found that cup users were older...
The SARS-CoV-2 pandemic has led to an unprecedented daily use of molecular RT-PCR tests. These tests are interpreted qualitatively for diagnosis, and the relevance test result intensity, i.e. number amplification cycles ( C t ), is debated because strong potential biases. We analyze a national database performed on more than 2 million individuals between January November 2020. Although we find values vary depending testing laboratory or assay used, detect significant trends with patient age,...
Human papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of latter in cervical cancer is controversial but its long-term infections might modulate mucosal microenvironment a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, studying immunological microbiological dynamics early stages these may help identify or rule out potential interactions. report two...
Mathematical models have unanimously predicted that a first-generation HIV vaccine would be useful and cost-effective to roll out, but its overall impact insufficient reverse the epidemic. Here, we explore what factors contribute most limiting of such vaccine.Ranging from theoretical ideal more realistic regimen, mirroring one used in currently ongoing trial South Africa (HVTN 702), model nested hierarchy attributes as speed scale-up, efficacy, durability, return rates for booster doses.The...