A5010165996- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Advancements in Transdermal Drug Delivery
- Proteins in Food Systems
- HIV Research and Treatment
- Advancements in Semiconductor Devices and Circuit Design
- Biosensors and Analytical Detection
- Heat Transfer and Boiling Studies
- Parasites and Host Interactions
- Malaria Research and Control
- Heat Transfer and Optimization
- Mosquito-borne diseases and control
- Child Nutrition and Feeding Issues
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
Bellevue Hospital Center
2011-2024
Intellectual Ventures (United States)
2011-2024
Institute for Disease Modeling
2016-2019
A newly developed platform capable of oral, ultra–long-acting drug delivery could be applied against the malaria vector in elimination programs.
Abstract The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden daily adherence have not yet been developed. Here we describe an oral dosage form composed distinct drug–polymer matrices which achieved week-long systemic drug levels antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations viral dynamics patient patterns indicate such would reduce therapeutic failures...
Accurate medical recordkeeping is a major challenge in many low-resource settings where well-maintained centralized databases do not exist, contributing to 1.5 million vaccine-preventable deaths annually. Here, we present an approach encode history on patient using the spatial distribution of biocompatible, near-infrared quantum dots (NIR QDs) dermis. QDs are invisible naked eye yet detectable when exposed NIR light. with copper indium selenide core and aluminum-doped zinc sulfide shell were...
Abstract Accurate medical recordkeeping is important for personal and public health. Conventional forms of on‐patient information, such as alert bracelets or finger‐markings, may compromise patient privacy because they are readily visible to other people. Here, the development an invisible, temporary, easily deployable system reported. Information stored in unique patterns spatially distributed near‐infrared (NIR) fluorescent quantum dots (QDs), which delivered skin using dissolvable...
Micronutrient deficiencies affect up to 2 billion people and are the leading cause of cognitive physical disorders in developing world. Food fortification is effective treating micronutrient deficiencies; however, its global implementation has been limited by technical challenges maintaining stability during cooking storage. We hypothesized that polymer-based encapsulation could address this facilitate absorption. identified...
In 1980, high-performance computing was becoming limited by the heat dissipated in semiconductor chips. IBM introducing a new chip packaging technology that featured specific thermal conductance of about 5000 W/m2·°C and occupied approximately 1 liter space order to cool 300 W. also developing superconducting computer circumvent problem posed continued scaling The following year, two us (DBT RFWP) showed theoretically experimentally down dimensions conventional plate-fin liquid-cooled sink...