A5101522443- Fungal Plant Pathogen Control
- Software-Defined Networks and 5G
- Network Security and Intrusion Detection
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Phytochemical Studies and Bioactivities
- Plant-Microbe Interactions and Immunity
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Kruppel-like factors research
- MXene and MAX Phase Materials
- Bioactive Compounds and Antitumor Agents
- Flavonoids in Medical Research
- Neuroblastoma Research and Treatments
- Cancer Mechanisms and Therapy
- Insect Utilization and Effects
- Cancer-related molecular mechanisms research
- Insect and Pesticide Research
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Biopolymer Synthesis and Applications
- Genetic factors in colorectal cancer
Guizhou University
2024-2025
Fujian Provincial Cancer Hospital
2018-2025
Fujian Medical University
2018-2025
Nanjing Forestry University
2024
Shenzhen Technology University
2024
Shandong University of Traditional Chinese Medicine
2023
Sichuan University
2023
Southern Medical University
2023
Army Medical University
2022
Beijing University of Posts and Telecommunications
2019-2021
A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC50 values for the curative tobacco mosaic virus (TMV) by Z6 Z22 108.2 102.7 μg/mL, respectively, outperforming control agent ningenmycin (NNM) with an value 253.8 μg/mL. Additionally, protective activity Z21 100.9 123.2 also surpassing NNM 203.7 Microscale thermophoresis (MST) molecular docking test showed that bound well coat protein (TMV-CP). biological safety had almost no effect on...
Dendritic cell (DC)-derived exosomes (Dexs) have been proved to induce and enhance antigen-specific T responses in vivo, previous clinical trials shown the feasibility safety of Dexs multiple human cancers. However, there is little knowledge on efficacy against hepatocellular carcinoma (HCC) until now.In this study, peripheral blood-derived DCs were loaded with recombinant adeno-associated viral vector (rAAV)-carrying alpha-fetoprotein (AFP) gene (rAAV/AFP), high-purity generated. Then naive...
Abstract BACKGROUND Fungal diseases of plants have a serious impact on the quality and yield crops, some traditional pesticides can no longer cope with this problem. Therefore, it is great significance to develop new high efficiency low toxicity. RESULTS A series flavonoid derivatives containing benzothiazole were designed synthesized. Among them, compounds V17 , V12 V13 had excellent inhibitory effect against Fusarium oxysporum f. sp. cucumerinu half‐maximal concentration (EC 50 ) values...
<title>Abstract</title> This study investigates the molecular mechanisms underlying acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). First, we utilized NSCLC cells, organoids (LCOs), xenograft tumor, and patient-derived orthotopic xenografts tumor models establish TKI resistance. Their stem cell-like properties, drug sensitivity, formation vitro vivo transcriptomic profiles were analyzed. The...
Inhibitor of DNA binding 1 (Id1) is upregulated in multiple cancers, and Id1overexpression correlates with cancer aggressiveness poor clinical outcomes patients. However, its roles stem-like cells (CSCs) epithelial-mesenchymal transition (EMT) are still elusive.This study aimed to examine the role Id1 on mediation CRC stemness explore underlying mechanisms.Id1 CD133 expression was detected by qPCR assay immunohistochemistry (IHC) normal mucosal primary colorectal (CRC) specimens. stably...
Circular RNAs have been extensively studied in eukaryotes, but their presence and/or biological functionality bacteria are unclear. Here, we show that a regulatory noncoding RNA (DucS) exists both linear and circular conformation Bacillus altitudinis. The forms promote B. altitudinis tolerance to H2O2 stress, partly through increased translation of stress-responsive gene, htrA. 3' end sequences the crucial for circularization, formation can decrease levels cognates. Bioinformatic analysis...
Angiogenesis is a significant pathogenic characteristic of diabetic microangiopathy. Advanced glycation end products (AGEs) are considerably elevated in tissues and can affect vascular endothelial cell shape function. Regulation the growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling pathway critical mechanism regulation angiogenesis, VEGFR2 activity be modified by post-translational changes. However, little research has been conducted on control small ubiquitin-related modifier...
Network slicing (NS) is a promising technology of 5G that provides customized end-to-end network service to multi-tenant. How improve resource utilization efficiency with guarantee performance isolation in shared infrastructure one the main challenges allocation problem NS. To address this challenge, we characterize degree based on relationship between requested amount, allocated and time-varying loads. We propose dynamic probabilistic (DRAIG), which formulated as chance constrained program....
Id4 is one of the inhibitors DNA-binding proteins (Id) and involved in pathogenesis numerous cancers. The specific mechanism underlying Id4-mediated regulation proliferation, invasion, metastasis colorectal cancer (CRC) cells still largely unclear. In present study, results showed CRC had a lower baseline expression than normal intestinal epithelial NCM460 cells. order to explore role tumorigenicity, HCT116 with stable were used, overexpression arrested cell cycle at G0/G1 phase, inhibited...
Data fusion is currently used extensively in information retrieval for various tasks. It has proved to be a useful technology because it able improve performance frequently. However, almost all prior research data fusion, static search environments have been used, and dynamic generally not considered. In this article, we investigate adaptive methods that can change their behavior when the environment changes. Three are proposed investigated. To test these properly, generate benchmark from...
A fraction with molecular weight of 0.2–1.0 kDa was prepared from abalone viscera hydrolysate by ultrafiltration and nanofiltration. The contents protein, carbohydrate, fat in were 45.75%, 18.19%, 13.60%, respectively. protein faction (AVHF) reached up to 75.73%, while carbohydrate fell 1.80% 0.20%, leucine (Leu) content the highest AVHF. On other hand, hydroxyl 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities reducing power increased concentration inhibiting ability AVHF on lipid...
Abstract The functionalization of small aromatic heterocycles is a straight and efficient method to access large polycyclic conjugated molecules. However, due its unique reactivity, the derivatization acridone usually gives product in angular shape difficult obtain linear ones. Here we report direct generate linearly fused derivatives containing cyclobutadienoid via palladium‐catalyzed arene‐(oxa)norbornene annulation followed by dehydrated aromatization. experimental characterizations...
Network slicing (NS) is a promising technology of 5G that provides end-to-end customized network service to multi-tenant. The embedding (NSE) problem one the essential issues in NS technology. In most NSE solutions, resource conservation dedicated and utilization-inefficient. Applying sharing into direct way improve utilization, but introduce collision risk. This paper puts forward novel solution with risk-controlled sharing, namely NSE-RRS. We abstract embedded slices' loads as...
To study the effect of eukaryotic initiation factor 3B (EIF3B) on invasion and migration hepatocellular carcinoma (HCC) its potential mechanism.
<title>Abstract</title> A series of flavonol derivatives containing benzothiazole were designed and synthesized. The structures all the compounds characterized by NMR HRMS. results bioactivity assay showed that some target possessed outstanding <italic>in vivo</italic> antiviral activity against tobacco mosaic virus (TMV). Among them, median effective concentration (EC<sub>50</sub>) <bold>L20</bold> was 90.5 µg/mL for curative activities TMV, which better than ningnanmycin (NNM: 252.0...
This letter studies the problem of optimizing decision latency for software-defined networking (SDN) structured by multiple controllers. According to mode processing non-local tasks in SDN, we propose a novel model this multi-controller structure, which generalizes traditional flat and hierarchical structures. We formulate location (DLP) optimize based on model. It is shown that DLP flow initialization can be reformulated as 0-1 integer optimization problem, use heuristic genetic algorithm...