A5100665428- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Cervical Cancer and HPV Research
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- vaccines and immunoinformatics approaches
Fujian Medical University
2015-2025
Fujian Provincial Cancer Hospital
2015-2025
Epstein-Barr virus (EBV) is ubiquitously associated with nasopharyngeal carcinoma (NPC). EBV encodes two groups of microRNAs (miRNAs) which are divided into BamHI fragment H rightward open reading frame 1 (BHRF1) and BamHI-A transcripts (BART) microRNAs. miR-BART has been found to be involved in the development progression NPC. However, so far role EBV-miR-BART8-3p NPC remains unknown. This study aimed investigate explore underlying mechanisms.miRNA expression was profiled normal mucosal...
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little known about role hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate expression 177 pairs human HCC adjacent liver tissue samples. The vitro migration cell lines evaluated MHCC97H, LM3 SMMC7721 cells. Microarray analysis applied explore molecular mechanism through which promoted Quantitative real-time PCR Western...
Dendritic cell (DC)-derived exosomes (Dexs) have been proved to induce and enhance antigen-specific T responses in vivo, previous clinical trials shown the feasibility safety of Dexs multiple human cancers. However, there is little knowledge on efficacy against hepatocellular carcinoma (HCC) until now.In this study, peripheral blood-derived DCs were loaded with recombinant adeno-associated viral vector (rAAV)-carrying alpha-fetoprotein (AFP) gene (rAAV/AFP), high-purity generated. Then naive...
The inhibitor of DNA binding protein ID3 has been associated with the progression colorectal cancer (CRC). Despite its significance, specific role in immune evasion strategies utilized by CRC remains unclear. RNA-seq analysis revealed that was positively PD-L1 checkpoint. We further demonstrated tumor cell–expressed enhanced expression, suppressed infiltration and activation CD8 + T cells, facilitated cells. Additionally, we found knockdown significantly effectiveness antibody blockade...
Abstract Background: In a previous study, we found that heat shock protein 27 (HSP27) was over-expressed in gastric adenocarcinoma (GA) tissue. this our goal to further verify the expression profile of HSP27 patients with GA. Methods: Western blot and immunohistochemistry were employed determine 50 paired tumor adjacent normal ELISA used quantify serum concentrations same GA healthy individuals. Results: Compared tissues, 25 (50%, p=0.000) 24 (48%, cases tissue by immunohistochemistry,...
ABSTRACT Hepatitis B spliced protein (HBSP) is involved in the pathogenicity and/or persistence of hepatitis virus (HBV). Chronic HBV infection one most important risk factors for development hepatocellular carcinoma (HCC). However, whether or not HBSP contributes to progression HBV-associated HCC remains unknown. This study reports that overexpression human hepatoma cells increased cell invasion and motility. Conversely, small interfering RNA (siRNA)-mediated knockdown expression inhibited...
Inhibitor of DNA binding 1 (Id1) is upregulated in multiple cancers, and Id1overexpression correlates with cancer aggressiveness poor clinical outcomes patients. However, its roles stem-like cells (CSCs) epithelial-mesenchymal transition (EMT) are still elusive.This study aimed to examine the role Id1 on mediation CRC stemness explore underlying mechanisms.Id1 CD133 expression was detected by qPCR assay immunohistochemistry (IHC) normal mucosal primary colorectal (CRC) specimens. stably...
Chimeric antigen receptor (CAR) T cells have been proven effective for the treatment of B-cell-mediated malignancies. Currently, development efficient tools that supply CAR other malignancies would great impact. In this study, interleukin (IL)-15 and C-C motif chemokine ligand 19 (CCL19) were introduced into natural killer group 2D (NKG2D)-based CARs to generate 15×19 cells, which remarkably increased T-cell expansion promoted production central memory (T cm ) cells. showed greater...
Cervical cancer is the fourth leading cause of mortality in women worldwide. High‑risk human papillomavirus infection a major cervical cancer. A previous study revealed role different oncogenes and tumor suppressors initiation progression. However, complicated genetic network regulating remains largely unknown. The present reported transcriptome sequencing analysis three squamous cell tissues paired normal tissues. Transcriptomic that 2,519 genes were differently expressed between their...
Abstract In countries where hepatitis B virus (HBV) is endemic, a high incidence of hepatocellular carcinoma (HCC) occur in HBV carriers and the prolonged replication expression proteins liver considered an important risk factor for progression to malignancy. However, mechanism pathogenesis HBV‐associated remains elusive. this study, human hepatoblastoma HepG2 cell line harboring 1.2 × unit‐length genome was generated subjected proteomic approach analyzing global protein profiles cells with...
Abstract Background The risk of hepatocellular carcinoma (HCC) increases in chronic hepatitis B surface antigen (HBsAg) carriers who often have concomitant increase the levels benzo[alpha]pyrene-7,8-diol-9,10-epoxide(±) (BPDE)-DNA adduct liver tissues, suggesting a possible co-carcinogenesis Hepatitis virus (HBV) and benzo[alpha]pyrene HCC; however exact mechanisms involved are unclear. Methods interaction between spliced protein (HBSP) microsomal epoxide hydrolase (mEH) was confirmed using...
Abstract High‐frequency mutation of the TP53 tumor suppressor gene is observed in multiple human cancers, which promotes cancer progression. However, mutated gene‐encoded protein may serve as a antigen to elicit tumor‐specific immune responses. In this study, we detected widespread expression shared TP53‐Y220C neoantigen hepatocellular carcinoma with low affinity and stability binding HLA‐A0201 molecules. We substituted amino acid sequences VVPCEPPEV VLPCEPPEV yield (L2) neoantigen. This...
Abstract Conventional treatments have shown a limited efficacy for pancreatic cancer, and immunotherapy is an emerging option treatment of this highly fatal malignancy. Neoantigen critical to improving the tumor-specific immunotherapy. The cancer peripheral blood specimens from HLA-A0201–positive patient were subjected next-generation sequencing, bioinformatics analyses performed screen high-affinity stable neoepitopes. activation cytotoxic T lymphocytes (CTLs) by dendritic cells (DCs)...