A5003424592- Microfluidic and Capillary Electrophoresis Applications
- Corporate Governance and Management
- Digital Innovation in Industries
- Neuroscience and Neural Engineering
- Nanofabrication and Lithography Techniques
- Analytical Chemistry and Sensors
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Electrowetting and Microfluidic Technologies
- Photoreceptor and optogenetics research
- Advanced Biosensing Techniques and Applications
- Acoustic Wave Resonator Technologies
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Wireless Power Transfer Systems
- Advanced Sensor and Energy Harvesting Materials
- Advanced Surface Polishing Techniques
- Ultrasound Imaging and Elastography
- 3D IC and TSV technologies
- Advanced MEMS and NEMS Technologies
- Modular Robots and Swarm Intelligence
- Wireless Body Area Networks
- Energy Harvesting in Wireless Networks
- Corporate Management and Leadership
- Advanced Fluorescence Microscopy Techniques
Fraunhofer Institute for Biomedical Engineering
2012-2025
Bayer (Germany)
2023
Fraunhofer Society
2006-2021
Saarland University
2006
Abstract Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses rapid animal‐free risk assessment of new chemicals drugs. cell‐based devices allow high‐throughput screening flexible automation while lowering costs reagent consumption due to their miniaturization. There growing need faster approaches drug development safety (Registration, Evaluation, Authorisation Restriction Chemical Substances, REACH). The work presented...
ABSTRACT Cell‐based neutralization assays are of central importance for the development new vaccine candidates as well quality assurance already approved vaccines. Suppression viral infection by neutralizing antibodies present in serum vaccinated individuals serves an indicator efficacy a vaccine. Established readouts used to date hardly automated, provide no time resolution and require expensive reagents. These shortcomings limiting factors development. In contrast, when virus‐compatible...
This paper reports on a polymer-based piezoelectric transducer used in microfluidic structures for generating acoustic waves, and consequently, the streaming phenomenon, that will improve mixing of fluids. The is based poly(vinylidene fluoride-trifluoroethylene), P(VDF-TrFE), copolymer with conductive transparent electrodes aluminum doped zinc oxide (AZO). efficiency optimized P(VDF-TrFE) fluids was studied using two diagnostic kits quantification uric acid nitrite blood. In both cases,...
A major challenge of drug discovery is to overcome the mucus barrier, which lined surface gastrointestinal tract. The ability this barrier must be tested in preclinical vitro models, prior vivo studies. Therefore, a microfluidic chip was developed examine possibility compounds barrier. Native porcine intestinal used as model. loaded inside comprising microporous membrane and fluidic compartment. To validate system, caffeine hydrophilic positive compound, fluorescein isothiocyanate–dextran...
For the treatment of intestinal tumors by oral administration drugs, mucus layer intestine represents a barrier, but also target possibility for drug. The use nanoparticular drug delivery systems is an important tool to improve transport and accumulation on side. Therefore, specific in vitro test simulate conditions tumor are necessary screening efficiency testing potential new systems. Here, we introduce microfluidic 3D spheroid model, which allows functionalized nanoparticles their ability...
Today acoustic microscopy transducers are based on zinc oxide, ZnO, films as piezoelectric material. Especially in the GHz range insertion loss of existing ZnO has to be improved for better imaging. The motivation this work was substitute by material lead zirconate titanate, PZT, with electro mechanical properties. Novel technologies sol-gel and metal organic chemical vapor deposition method (MOCVD) were used realize high frequency PZT thin film 200 ¿m aperture diameter. characterized...
A high-throughput, automated screening platform has been developed for the assessment of biological membrane damage caused by nanomaterials. Membrane is detected using technique analyzing capacitance-current peak changes obtained through rapid cyclic voltammetry measurements a phospholipid self-assembled monolayer formed on mercury film deposited onto microfabricated platinum electrode after interaction biomembrane-active species. To significantly improve wider usability technique, compact,...
Abstract Purpose To develop and evaluate a photovoltaic, wireless wide‐field epiretinal prosthesis for the treatment of retinitis pigmentosa. Methods A mosaic array thinned silicon‐based photodiodes with integrated thin‐film stimulation electrodes was fabricated flexible polyimide substrate film to form film‐based miniaturized electronic system optical power signal transmission electrostimulation. Manufactured implants were characterized respect their optoelectronic performance...
Detection of early oesophageal cancer in surrounding normal tissue can be challenging, but detection is essential to determine the subsequent treatment. Dysplastic detected by using electrical impedance spectroscopy (EIS).The aim present study was evaluate feasibility and value EIS diagnosis neoplasia.This prospective ex-vivo included 23 patients with (17 Barrett's six squamous cell cancer). Immediately after endoscopic resection, properties resected specimens were investigated a pencil...
The authors report on the concept and development of an intelligent intraoral drug delivery microsystem, that provides alternative approach for treatment addiction chronic diseases. system (DDS) comprises a medication replacement reservoir, release mechanism, built-in intelligence, remote control, microsensors, microactuators. It is thus able to in controlled manner according patient needs. emphasis this article application sensors microfluidic components real microsystem also showing some...
This paper shows the feasibility of inductive data transmission between millimeter-sized (2 times 2 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) swarm robots. To fulfill size restraints, coils used for were fabricated by micromachining technologies. Since induced signal at receiving coil was very small due to low coupling coefficient, a high amplification gain amplifier necessary. Transmitter and receiver electronics...
A method is shown to produce silicon based acoustic lenses in the GHz-range for time resolved microscopy of biological cells. The avoids problem disturbing echoes from rim around lens cavity. Isotropic wet etched made have been demonstrated past. In this report micro machining process extended with a dry etching step avoid echo which enables use short working distance good signal noise ratio time-resolved microscopy. deepening about 15 mum moves behind target and therefore assists overcoming...
Objective. To explore noise characteristics and the effect physiological activity has on link between impedance noise.Approach. Dry-printed electrodes are emerging as a new exciting technology for skin electro-physiology. Such electrode arrays offer many advantages including user convenience, quick placement, high resolution. Here we analyze extensive electro-physiological data recorded from arm face to study quantify of dry electrodes, characterize impedance. In particular, studied state...
Microrobotic technology underlines the concept of top–down fabrication autonomous or semi-autonomous robotic systems, with final aim to produce micromachines. For millimetre-sized robots, all sub-component modules must be conceived and designed as minimal components able accomplish a specific basic task, each them consequently represents fundamental part in whole microrobotic system. Communication sensing modules, particular, are indispensable microrobot order physically interact its...
The integration of a fluorescence microscopy/spectroscopy module in cell-based lab-on-a-chip systems is high interest for applications diagnostics and substance evaluation situ. We present an on-chip integrated lensless imaging applying the principle contact/proximate optical lithography. pixel resolution comparable with 4 x objective microscope. can be used morphology mammalian cells (15 - 20 μm) as well testing concentration fluorescent substance. biological samples or solutions are...
Biosensors become increasingly relevant for medical diagnostics, pharmaceutical industry, and environmental technology, example, to test new drugs easily reliably or detect cell growth in changing conditions. Novel materials like graphene are promising candidates produce biosensors on an industrial scale by means of printing processes. To reach this aim, methods the reliable automated production electrode structures their coating required. We present impedance biosensor format a microtiter...
Lab-on-a-chip systems are increasingly applied in cell-based assays for toxicology and drug testing. In this paper, an on-chip integrated lensless microscopy module using a direct projection method optical monitoring of the shadow images adherent growing mammalian cells is presented. The biological conserved interfaced by microfabricated cavity chip with 1 microm thick silicon nitride (Si(3)N(4)) substrate onto surface 5 megapixel CMOS image sensor 2.2 pixel size. resolution assembly...