A5102848668- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Electrolyte and hormonal disorders
- Intensive Care Unit Cognitive Disorders
- Dysphagia Assessment and Management
- Spinal Cord Injury Research
- Aortic Disease and Treatment Approaches
- Musculoskeletal pain and rehabilitation
- Abdominal Surgery and Complications
- Spinal Dysraphism and Malformations
- Dialysis and Renal Disease Management
- Muscle metabolism and nutrition
- Pelvic and Acetabular Injuries
- Metabolism and Genetic Disorders
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Trauma Management and Diagnosis
- Respiratory Support and Mechanisms
- Hydrogen Storage and Materials
- Acute Kidney Injury Research
- Artificial Intelligence in Healthcare and Education
- Cervical and Thoracic Myelopathy
Kitasato University
2018-2025
Otsuka (Japan)
2020-2025
Otsuka Pharmaceutical (Spain)
2022
Shonan University of Medical Sciences
2020-2022
Kitasato University Hospital
2020
Hokkaido University
2017
The University of Tokyo
1973-2012
Kurashiki University of Science and the Arts
2000
Okayama University
1996
Background On April 16, 2020, the Japanese government declared a state of emergency due to spread COVID-19 infection, leading prefectural governors announce stay-at-home order for 39 days until May 25, 2020. As physical inactivity is risk factor osteoporosis, we investigated short-term impact on bone health among patients with osteoporosis in our hospital Kanagawa prefecture. Methods Thirty no delays their regular medication who received care at hospital's outpatient clinic within one month...
Macrophages produce proinflammatory cytokines in injured intervertebral discs (IVDs). We recently showed that macrophage-derived inflammatory contribute to the production of pain-related factors. However, mechanism by which macrophages are recruited IVDs has not been fully clarified. Here, we examined expression dynamics chemokine CCL2 a mouse IVD injury model and mechanisms its regulation. The percentage increased from day 1 after persisted up until 28. At 3 days injury, both Ccl2 messenger...
This study aimed to describe real-world nutrition management patterns among inpatients hospitalized for aspiration pneumonia, using a medical claims database in Japan.Patients aged ≥65 years pneumonia treatment were identified between January 2013 and December 2018, evaluate initiation adjustment timing, factors associated with >7-days nil per os (NPO) status, prescribed doses, types of parenteral solutions. Patients who received oral intake or enteral on the day admission (Day 1)...
Age is a key factor in intervertebral disc (IVD) degeneration; however, the changes that occur IVDs with age are not fully understood. Tissue-resident macrophages critical for tissue homeostasis and regulated by transforming growth factor- (TGF-) β. We examined proportion of resident young versus aged mice role TGF-β regulating IVDs. were harvested from 4-month (young) 18-month-old (aged) C57BL/6J mice. The was determined using flow cytometry ( <math...
Abstract Sarcopenia is defined as decreasing in muscle strength and mass, dynapenia maintained mass. This study elucidated the prevalence characteristics of sarcopenia evaluate elderly spinal disorders patients. 1039 patients aged ≥ 65 years were included. We measured age, grip strength, sagittal alignment parameters, low back pain (LBP) scores health-related quality life (HR-QoL) scores. Based on previous reports, categorised into normal group: NG, pre-sarcopenia PG, DG, SG. Pre-sarcopenia,...
For older patients with decreased reserve function, traumatic cervical spine injuries frequently lead to early mortality. However, the prognostic factors for mortality remain unclear. This study included aged ≥65 years and hospitalized treatment of in 78 hospitals between 2010 2020. Early was defined as death within 90 days after injury. We evaluated relationship following factors: age, sex, body mass index, history drinking smoking, injury mechanisms, presence a fracture dislocation,...
Abstract This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included aged ≥ 65 years traumatic SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 (mean follow-up: 20.1 months) were examined 47 had major risks admission. One-year rate, median survival time, recovery, activities daily...
Acetals derived from 1,2- or 1,3-diols bearing neighboring hydroxyl group can be selectively cleaved at the acetal C-O bond proximate to on treatment initially with BH3⋅SMe2 for 1 h (0 °C-rt) and successfully BF3⋅Et2O 5 min 0 °C.
Animal studies suggest that pain-related-molecule upregulation in degenerated intervertebral discs (IVDs) potentially leads to low back pain (LBP). We hypothesized IVD mechanical stress and axial loading contribute discogenic LBP's pathomechanism. This study aimed elucidate the relationships among clinical findings, radiographical expression human IVDs. harvested degenerated-IVD samples from 35 patients during spinal interbody fusion surgery. Pain-related molecules including tumor necrosis...
Background and Objectives: Several predictive factors have been reportedly associated with intraoperative total blood loss (TBL) during posterior spinal fusion (PSF) for idiopathic scoliosis (IS). To reduce TBL, preoperative interoperative are considered important. However, there few reports that evaluated bleeding patterns according to surgical stages. This study aimed elucidate at different stages determine the TBL PSF surgery in patients IS. Materials Methods: Preoperative data,...
Background & aimsIdentifying the prevalence of underfed patients and risk factors for underfeeding in with total parenteral nutrition (TPN) is essential to improve management receiving TPN. The aim this study was examine using a medical claims database.MethodsIn retrospective cohort database, we analyzed patient characteristics, timing duration prescription, daily dose nutrients, types products administered after central venous catheter (CVC) insertion hospitalized Japanese between 2009...
Abstract Background Recently, Oblique lumbar interbody fusion (OLIF) is commonly indicated to correct the sagittal and coronal alignment in adult spinal deformity (ASD). Endplate fracture during surgery a major complication of OLIF, but detailed location vertebral endplate ASD has not yet been determined. We sought determine incidence subsidence OLIF cage surgery, its association with status alignment. Methods analyzed 75 levels 27 patients were using multiplanar CT detect immediately after...
Introduction: Spinal muscular atrophy (SMA) is defined as a neuromuscular disorder induced by progressive weakness of the skeletal muscle and usually accompanied spinal deformity including scoliosis. The newly developed Nusinersen, which first approved drug worldwide for SMA, requires accurate intrathecal injection, sometimes difficult in patients with severe deformity.
In patients receiving parenteral nutrition (PN), the association between achievement in accordance with guidelines and outcomes remains unclear. Our purpose was to assess clinical outcomes, including in-hospital mortality, activity of daily living (ADL), readmission.In this retrospective cohort study, data were extracted from an inpatient medical-claims database at 380 acute care hospitals. This study included who underwent central venous catheter insertion January 2009 December 2018....
We aimed to retrospectively investigate the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. enrolled 1512 aged ≥ 65 years registered a multicenter study database. Patients were divided into two groups according presence dementia, 95 (6.3%) had Univariate analysis revealed that dementia group comprised who older predominantly female lower body mass index, higher modified 5-item frailty index (mFI-5), pre-injury activities...
Background and objectives: Patients with neuromuscular diseases usually have progressive scoliosis (NMS), requiring invasive surgery. Some patients present severe at the time of consultation are difficult to treat. Posterior spinal fusion (PSF) surgery combined anterior release pre- or intraoperative traction would be effective for deformities but invasive. This study aimed evaluate outcomes PSF-only NMS a Cobb angle > 100°. Materials Methods: Thirty (13 boys 17 girls; mean age 13.8 years)...
Guidelines for the nutritional management of critically ill patients recommend use injectable lipid emulsion (ILE) as part parenteral nutrition (PN). The ILE's impact on outcomes remains unclear. Associations between prescribed ILE and in-hospital mortality, hospital readmission, length stay (LOS) in intensive care unit (ICU) were investigated. Patients who ≥18 years old an ICU from January 2010 through June 2020, receiving mechanical ventilation, fasting >7 days, selected a Japanese medical...
Some critically ill patients completely rely on parenteral nutrition (PN), which often cannot provide sufficient energy/amino acids. We investigated the relationship between PN doses of acids and clinical outcomes in a retrospective cohort study using medical claims database (≥10.5 years, from Japan, involving 20,773 adult intensive care unit (ICU) mechanical ventilation exclusively receiving PN). Study patients: >70 years old, 63.0%; male, 63.3%; BMI < 22.5, 56.3%. Initiation PN:...