A5064072634- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- NF-κB Signaling Pathways
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Cancer and Skin Lesions
- AI in cancer detection
- Venous Thromboembolism Diagnosis and Management
- Breast Lesions and Carcinomas
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Ear and Head Tumors
- Cancer, Hypoxia, and Metabolism
- Digital Imaging for Blood Diseases
- Renal and related cancers
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Risks and Factors
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
Newcastle University
1999-2024
Dana-Farber Cancer Institute
2023-2024
Westmead Hospital
2020
Lancaster University
2016
Royal Hobart Hospital
2013
Due to the rarity of TP53 mutations in acute lymphoblastic leukemia (ALL), p53 re-activation by antagonism p53-MDM2 interaction represents a potential therapeutic strategy for majority ALL. Here, we demonstrate potent antileukemic activity MDM2 antagonist idasanutlin high-risk and relapsed ex vivo coculture models wildtype ALL (n = 40). Insufficient clinical responses monotherapy inhibitors other cancers prompted us explore optimal drugs combination therapy. Utilizing high-throughput...
The purpose of this study was to determine the oestrogen and progesterone receptor status a selection salivary tumours. Using immunohistochemistry, we detected nine six positive tumours from sample 36. One acinic cell carcinoma two mucoepidermoid carcinomas demonstrated positivity for both receptors. We suggest that there may be role manipulation in management some
Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model lymphoma results earlier onset disease, a finding contrasted with expected function this NF-κB subunit B-cell malignancies. Here report Eµ-Myc/cRel−/− cells have an unexpected and major defect CHK1 pathway. Total phospho proteomic analysis revealed lymphomas highly resemble wild-type (WT) treated acute dose inhibitor (CHK1i) CCT244747. Further demonstrated is consequence having lost expression protein itself, effect...
Persistence of residual disease in acute lymphoblastic leukemia (ALL) during the initial stages chemotherapy is associated with inferior survival. To better understand clonal evolution and mechanisms chemoresistance, we used multiparameter mass cytometry, at single-cell resolution, to functionally characterize pediatric B-ALL cells presentation those persisting induction therapy. Analysis ALL from samples (n=42) showed that most abundant phosphosignals were pCREB, pH2AX pHH3 identified...
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient acute myeloid leukemia (AML) that was chemoresistant anthracycline and cytarabine acutely sensitive 5'-azacitidine (5'-Aza) hypomethylating monotherapy, resulting long-term morphological remission. Given the role...
This article reviews breast disorders which can present as palpable masses during pregnancy or lactation. It focuses on the most common differential diagnoses: galactocele, fibroadenoma, lactating adenoma, mastitis and abscess, pregnancy-associated cancer. doi: http://dx.doi.org/10.4021/jcgo140w
Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need novel therapies to improve outcomes. Targeted inhibition of WEE1 small-molecule inhibitor adavosertib (AZD1775) has emerged as therapeutic strategy sensitize cancer cells DNA-damaging chemotherapeutics, particularly in the context TP53-mutated tumors. However, potential high-risk ALL, including those TP53 mutations, not been definitively evaluated.Anti-leukemic effects were investigated using...
The poor efficacy of many cancer chemotherapeutics, which are often non-selective and highly toxic, is attributable to the remarkable heterogeneity adaptability cells. Warburg effect describes up regulation glycolysis as main source adenosine 5'-triphosphate in cells, even under normoxic conditions, a unique metabolic phenotype Mitochondrial suppression also observed may be implicated apoptotic increased funneling respiratory substrates anabolic processes, conferring survival advantage....
This protocol describes a non-informatics based approach to high-content image analysis of acute leukemia cells in co-culture with mesenchymal stromal (MSCs) using supervised machine learning. The pipeline leverages two powerful, open-source software applications - Cell Profiler and Ilastik. aim this is provide basic skeleton for to, at minimum, determine absolute cell numbers each class from fluorescence microscopy stained DNA dye. detailed companion walkthrough the Github repository...
Autocrine TNF can promote cell survival and leukaemia progression is associated with poor prognosis. SMAC-mimetics (SM), pharmacological inhibitors of IAPs, are critical regulators TNF-signalling able to sensitise leukaemias TNF-induced death. Here, we examine the mechanism SM-sensitivity by investigating individual components TNF-system.
A patient undergoes intracranial stent insertion for stent-assisted coiling of a basilar tip aneurysm and left middle cerebral artery aneurysm. flow diverting is also placed across an anterior communicating Prior to the procedure, takes dual antiplatelet medications, being aspirin clopidogrel. Because concern regarding in-stent thrombus thromboembolic complications related stenting high rate clopidogrel resistance, preoperative platelet function testing (PFT) was undertaken ensure...
Background: Despite concerted efforts to optimize and intensify treatment approaches in adult acute lymphoblastic leukemia (ALL) more than half of patients still succumb their disease within 5 years diagnosis, emphasizing the limits current therapy critical requirement for effective safer therapeutics. Patient-derived xenograft (PDX) ALL models represent reliably predictive preclinical allow vivo amplification patient material quantities sufficient high-throughput screening applications....