A5000365989- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- Cardiac Imaging and Diagnostics
- Mosquito-borne diseases and control
- Advanced Glycation End Products research
- Multimedia Communication and Technology
- Travel-related health issues
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Fire effects on ecosystems
- Diabetes Management and Research
- SARS-CoV-2 detection and testing
- Cardiomyopathy and Myosin Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- COVID-19 and Mental Health
- Cardiovascular Function and Risk Factors
- COVID-19 epidemiological studies
- Web Data Mining and Analysis
- Advanced Wireless Communication Techniques
- Insect symbiosis and bacterial influences
- Image and Video Quality Assessment
- Chronic Kidney Disease and Diabetes
National Institute of Infectious Diseases
2024-2025
Nagasaki University
2014-2024
Kowa (Japan)
2021
Honda (Japan)
2019
Weatherford College
2019
Ministry of Health Labour and Welfare
2018
National Cerebral and Cardiovascular Center
2017
Juntendo University
2000-2016
Leading Age
2015
Research Institute for Tropical Medicine
2015
Japanese encephalitis (JE) remains a public health concern in several countries, and the Culex mosquito plays central role its transmission cycle. mosquitoes harbor wide range of viruses, including insect-specific viruses (ISVs), can transmit variety arthropod-borne (arboviruses) that cause human animal diseases. The current trend studies displays enhanced efforts to characterize virome through bulk RNA sequencing due possible arbovirus–ISV interactions; however, extent viral diversity taxon...
Candida auris (C. auris) was initially isolated from a Japanese patient, and this species is an emerging fungus nowadays owing to its long-term colonization capabilities high resistance antifungal drugs. However, accurate domestic epidemiology of C. remains unknown. We here collected isolates reported hospitals, public health centers, institutes based on the administrative liaison. Moreover, we stocked three nongovernmental laboratory companies. Seventy were during study period....
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease in East Asia. It thought that the SFTS virus (SFTSV) circulates between ticks and animals nature transmitted to humans by tick bites. endemic Nagasaki western Japan; however, epidemiological information regarding SFTSV not known. In this study, we performed IgG ELISAs neutralization antibody assays for a seroepidemiological survey using samples from wild boars captured six areas of Nagasaki. seropositive were found...
Yang Ge, MS; Leonardo Martinez, PhD; Shengzhi Sun, Zhiping Chen, MD; Feng Zhang, Fangyu Li, Wanwan Enfu Jinren Pan, Changwei Jimin Andreas Handel, Ling, Ye Shen, PhD
Abstract Ixodid ticks transmit several important viral pathogens. We isolated a new virus (Tofla virus: TFLV) from Heamaphysalis flava and formsensis in Japan. The full-genome sequences revealed that TFLV belonged to the genus Nairovirus , family Bunyaviridae . Phylogenetic analyses neutralization tests suggested is closely related Hazara it classified into Crimean-Congo hemorrhagic fever group. caused lethal infection IFNAR KO mice. TFLV-infected mice exhibited gastrointestinal disorder...
The laboratory mouse model is commonly employed to study the pathogenesis of encephalitic flaviviruses such as Japanese encephalitis virus (JEV). However, it known that some strains these viruses do not elicit a typical mortality dose response curve from this organism after peripheral infection and reason for has yet been fully understood. It suggested induction more vigorous Type-I IFN (IFN-I) might control early dissemination following increasing infectious challenge doses virus. Thus,...
// Daisuke Hayasaka 1,2 , Kodai Nishi 3 Takeshi Fuchigami 4 Kazuya Shiogama 5 Takanori Onouchi Satoshi Shimada Yutaka Tsutsumi and Kouichi Morita 1 Department of Virology, Institute Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan 2 Leading Graduate School Program, Radioisotope Atomic Bomb Diseases Institute, Hygienic Chemistry, Biomedical Sciences, Bunkyo-machi, Pathology, Fujita Health University Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Correspondence to: Hayasaka,...
Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by East/Central/South African (ECSA) genotype. However, pathogenesis genotype infection has not been fully explained. In this study, we examined pathogenic potential CHIKV ECSA M-30 (M-30) comparing it with that S-27 (S-27) in mice. Following low titer infections type-I IFN receptor KO (A129) mice, found high and acute fatality compared infection. M-30-infected A129 mice showed higher viral loads their central nervous...
Multivessel spasm in variant angina is believed to be a major prognostic factor. Three patterns of multivessel have been detected: (1) at different sites on occasions (migratory spasm); (2) sequentially affecting 2 (sequential and (3) simultaneous more than 1 site (simultaneous spasm). The present study investigated the prognosis based this factor for without fixed coronary stenosis examined influence cardiac events. Twenty-six patients were diagnosed as having using 12-lead 24-h ECG...
This study describes the acute and chronic effects of dual-chamber (DDD) pacing in 14 consecutive patients with hypertrophic obstructive cardiomyopathy (HOCM), whose symptoms were refractory to drug therapy. Although left ventricular (LV) outflow tract pressure gradients diminished from 106±47 62±33 mmHg (p<0.001) by temporary pacing, residual >30 majority those concomitant reductions cardiac output. The DDD was judged as insufficient patients. A pacemaker was, however, implanted 11...
Background/aims We previously reported that the visual field (VF) prediction model using variational Bayes linear regression (VBLR) is useful for accurately predicting VF progression in glaucoma (Invest Ophthalmol Vis Sci. 2014, 2018). constructed a measurement algorithm VBLR, and purpose of this study was to investigate its usefulness. Method 122 eyes 73 patients with open-angle were included current study. performed currently proposed VBLR programme AP-7700 perimetry (KOWA). measurements...