A5101475715- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Histiocytic Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Traumatic Brain Injury and Neurovascular Disturbances
- HER2/EGFR in Cancer Research
- Colorectal Cancer Surgical Treatments
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- TGF-β signaling in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
Shanghai Jiao Tong University
2012-2024
Renji Hospital
2012-2024
Shanxi Provincial Cancer Hospital
2021
Colorectal cancer (CRC) incidence has increased among patients aged <50 years. Exploring high-risk factors and screening populations may help lower early-onset CRC (EO-CRC) incidence. We developed noninvasive predictive models for EO-CRC investigated its risk factors.This retrospective multicenter study collected information on 1756 (811 with 945 healthy controls) from two medical centers in China. Sociodemographic features, clinical symptoms, family history, lifestyle, dietary were...
To investigate whether the expression of kallikrein 12 (KLK12) is related to development gastric cancer (GC) and determine role KLK12 in cells growth, invasion migration.Between September 2007 March 2008, 133 patients with histologically confirmed GC were recruited for study. Expression was detected samples from by quantitative real-time reverse transcription polymerase chain reaction immunohistochemistry. The relationship between protein clinicopathological features analyzed. difference...
Abstract Epithelial-mesenchymal transition (EMT) is associated with the invasive and metastatic phenotypes in colorectal cancer (CRC). However, mechanisms underlying EMT CRC are not completely understood. In this study, we find that HUNK inhibits metastasis of cells via its substrate GEF-H1 a kinase-dependent manner. Mechanistically, directly phosphorylates at serine 645 (S645) site, which activates RhoA consequently leads to cascade phosphorylation LIMK-1/CFL-1, thereby stabilizing F-actin...
Objective/Background and Aims. The gastrointestinal tract is rich in neurotransmitters, which play an essential role the occurrence development of tumors. We aimed to explore function neurotransmitters gastric cancer identify a suitable target treat patients future. Methods. Monoamine were detected tissue paired normal tissue, Cancer Genome Atlas was used differentially expressed norepinephrine-degrading synthetic enzymes. Quantitative real-time PCR Seahorse assay determine effect...
Complete surgical resection, accessible therapeutic targets and effective tyrosine kinase inhibitors (TKIs) have not completely cured gastrointestinal stromal tumours (GISTs), with most patients suffering from residual recurrence. The existence of nerve infiltration in GIST provides a way for tumour cells to escape local resection systemic targeted therapy, which may challenge the previous understanding its behaviour patterns inspire development more radical excision precise therapy....
Adenocarcinoma of the esophagogastric junction (AEG) patient immune characteristics were analyzed in this study, and these features compared with clinical pathology prognosis.The clinicopathological data prognostic information 96 AEG patients who admitted to Ren Ji Hospital between December 2008 2015 collected. PD-1/PD-L1, Tim-3/Gal-9, CD3/CD8/Foxp3 expression patients, as well correlation molecules survival time, analyzed. Comparisons count performed using chi-square test or Fisher's exact...
<title>Abstract</title> Background Delayed gastric emptying (DGE) is a significant complication in pylorus-preserving gastrectomy (PPG) which disturb the postoperative recovery. We modified infrapyloric dissection to preserve antral branch of right gastroepiploic vein (RGEV) PPG as preventive method DGE and investigate clinical outcomes. Methods Preservation RGEV was reviewed cT1N0M0 cancer patients underwent (<italic>n</italic> = 131) by single surgeon during 2018–2020. Presence evaluated...
Follicular dendritic cell sarcoma (FDCS) is a rare malignancy that arises from follicular cells and typically presents as slow-growing painless mass without specific symptoms. Here we report an unusual case of 55-year-old female with retroperitoneal FDCS who presented progressive abdominal pain onset acute exacerbation.On CTA, middle-upper (58*40 mm) was shown multiple enlarged lymph nodes. After en-bloc resection the tumor, patient recovered completely her symptoms discharged complication....
Objective To investigate rational surgical approaches for Siewert type I adenocarcinoma of the esophagogastric junction （ AEG）, and analyze prognostic factors. Methods The clinical data 103 patients with AEG who were admitted to Renji Hospital from January 2005 December 2009 retro- spectively analyzed. All divided into transthoracic approach group （61 patients） thoracoabdominal （42 patients）. incidences numbers lymph node dissected postoperative complications 2 groups compared using...