A5114950268- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Cryospheric studies and observations
- Arctic and Antarctic ice dynamics
- Climate change and permafrost
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal Cancer Treatments and Studies
- Retinal and Optic Conditions
- Angiogenesis and VEGF in Cancer
- PARP inhibition in cancer therapy
- Retinal Imaging and Analysis
- Connexins and lens biology
- Adrenal and Paraganglionic Tumors
- Hippo pathway signaling and YAP/TAZ
- Bacterial Infections and Vaccines
- Andrographolide Research and Applications
- Neuroblastoma Research and Treatments
- Influenza Virus Research Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Hemophilia Treatment and Research
- Dermatological and COVID-19 studies
- Assisted Reproductive Technology and Twin Pregnancy
- Hormonal Regulation and Hypertension
- Zebrafish Biomedical Research Applications
Second Affiliated Hospital of Nantong University
2021-2024
Nantong University
2018-2024
Zhejiang University
2021-2024
Affiliated Hospital of Nantong University
2018-2024
Renmin University of China
2024
Polar Research Institute of China
2023
Second People's Hospital of NanTong
2022
Nanjing Medical University
2016-2020
Jiangsu Province Hospital
2016-2020
Shanxi Normal University
2018
Geniposide (GEN) is a natural antioxidant and anti-inflammatory product plays an important role in the treatment of diabetes diabetic complications. To explore biological functions mechanism GEN retinopathy (DR), we constructed vitro vivo model DR by using primary cultured mouse retinal Müller cells C57BL/6 mice, respectively. We found that inhibited ROS accumulation, NF-κB activation, cell inflammatory cytokine secretion both vivo, which probably mediated through Nrf2 pathway. Exendin...
Increasing studies confirm that anti-angiogenesis can increase the effectiveness of immunotherapy. In this study, we found an angiogenesis inhibitor apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression. Apatinib treatment upregulated expression various cells both at mRNA and protein levels. Further, apatinib-treated hampered activation IFN-γ secretion T co-culture system, which was reversed by antibody. Based on this, combination with growth examined....
Wet age-related macular degeneration, which is characterized by choroidal neovascularization (CNV) and induces obvious vision loss. Vascular endothelial growth factor (VEGF) family member VEGF-A (also named as VEGF) its receptor VEGFR2 contribute to the pathogenesis of CNV. Choroidal cells (CECs) secret C-C motif chemokine ligand 2 (CCL2), attracts macrophages CNV lesion promotes macrophage M1 polarization. Accordingly, infiltrating inflammatory cytokines promote In vivo, intravitreal...
Purpose: This study examined the role of CSF1/CSF1Raxis in crosstalk between choroidal vascular endothelial cells (CVECs) and macrophages during formation neovascularization (CNV). Methods: Quantitative reverse transcriptase (QRT)-PCR, Western blot ELISA measured production release CSF1 from human (HCVECs) under hypoxic conditions. detected released HCVECs conditions that activated PI3K/AKT/FOXO1 axis via binding to CSF1R. Transwell migration assay, qRT-PCR, effect on macrophage M2...
BMS-1166, a PD-1/PD-L1 inhibitor, inhibits the binding of PD-L1 to PD-1, restores T cell function, and enhances tumor immune response. However, mutations in suppressor or impaired cellular signaling pathways may also lead transformation. In this study, SW480 SW480R lines were used as model elucidate treatment with BEZ235, their combination.
Abstract In age‐related macular degeneration (AMD), choroidal neovascularization (CNV), a major pathologic feature of neovascular AMD (nAMD), affects 10% patients, potentially causing serious complications, including vision loss. Vascular endothelial growth factor receptor 2 (VEGFR2) and fibroblast 1 (FGFR1) contribute to the pathogenesis CNV. Brivanib is an oral selective dual tyrosine kinase (RTK) inhibitor FGFRs VEGFRs, especially VEGFR2 FGFR1. this study, brivanib inhibited zebrafish...
Purpose . Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. This study examined whether LSS pathway has a role different subtypes of age-related (ARC). Methods A total 390 patients with ARC 88 age-matched non-ARC were enrolled this study. expression was analyzed by western blot enzyme-linked immunosorbent assay (ELISA). To further examine the function LSS, we used U18666A, an inhibitor rat culture system. Results...
Choroidal neovascularization (CNV), is a major cause of irreversible blindness among the elderly population in developed countries, which resulted from subretinal fibrosis without effective therapeutic strategies. Endothelial-to-mesenchymal transition (EndMT) choroidal vascular endothelial cells (CVECs) contributes to fibrosis. Lycopene (LYC), non-pro-vitamin A carotenoid, plays an anti-fibrotic role. Herein, we explored effect and mechanism LYC on EndMT CVECs during CNV. Firstly, inhibited...
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease, characterized by excessive accumulation of fibroblasts, extensive deposition extracellular matrix, destruction alveolar architecture. IPF associated with an epithelial-dependent fibroblast-activated process, termed the epithelial-to-mesenchymal transition (EMT). However, there still lack strategies to target EMT for treatment IPF. Sunitinib, small-molecule multi-targeted tyrosine kinase inhibitor, targets multiple...
Purpose The present study aims to discover novel serum biomarkers of early‐onset myocardial infarction (MI) using proteomic analysis. Experimental design In the first stage, iTRAQ‐coupled LC–MS/MS technique is utilized investigate protein profiles patients with MI. second these candidate proteins are validated ELISA. Results A total 538 quantified, pregnancy zone (PZP), leucine‐rich α‐2‐glycoprotein (LRG) and Apolipoprotein C‐I (Apo C‐I) being upregulated A‐I A‐I) A‐IV A‐IV) downregulated in...
Summary In this paper, we present a susceptible‐infected‐recovered cross‐immune (SIRC) epidemic model, which describes Influenza A and analyzes the SIRC model through optimal control theory mathematical analysis. We show existence of an pair for problem by using Pontryagin's maximum principle with delay derive optimality condition. Finally, numerical simulation is carried out to verify our theoretical results.
Apatinib is an inhibitor of VEGFR2 (vascular endothelial growth factor receptor 2) that has attracted a great deal attention due to its promotion anticancer activity. In the present study, we investigated therapeutic effects apatinib against colorectal cancer (CRC) and examined underlying mechanism.Both in vivo vitro assays were conducted study effect on CRC. To elucidate associated mechanism, RNA-seq (transcriptome) analysis was apatinib-treated HCT116 cells.Apatinib showed...
Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The data including manifestations,laboratory tests,and imaging findings 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these patients,102 cases (89.4%) male. average age was 21.1?6.1 years. A history breech delivery documented 91 (91.9%). Short stature found 89 (71.8%) and bone delayed (6.1?5.1) Secondary sex poor or undeveloped most patients. prevalence...