A5020969463- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Comparative constitutional jurisprudence studies
- Pediatric Hepatobiliary Diseases and Treatments
- Probiotics and Fermented Foods
- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Recycling and Waste Management Techniques
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Biochemical Analysis and Sensing Techniques
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Human Rights and Immigration
- Food composition and properties
- Nutritional Studies and Diet
- Barrier Structure and Function Studies
- Oral microbiology and periodontitis research
- Conflict, Peace, and Violence in Colombia
- Phytochemicals and Antioxidant Activities
- Gastrointestinal motility and disorders
- Latin American Cultural Politics
Instituto de Investigación en Ciencias de la Alimentación
2021-2024
Universidad Autónoma de Madrid
2021-2024
Instituto de Productos Lácteos de Asturias
2018-2022
Consejo Superior de Investigaciones Científicas
2018-2022
Instituto de Investigación Sanitaria del Principado de Asturias
2020-2022
University of Aberdeen
2007
The gut microbiota has emerged as a key factor in the pathogenesis of intestinal viruses, including enteroviruses, noroviruses and rotaviruses (RVs), where stimulatory inhibitory effects on infectivity have been reported. With aim determining whether members interact with RVs during infection, combination anti-RV antibody labeling, fluorescence-activated cell sorting 16S rRNA amplicon sequencing was used to characterize interaction between specific bacteria RV stool samples children...
Abstract Microplastics (MPs) are a widely recognized global problem due to their prevalence in natural environments and the food chain. However, impact of microplastics on human microbiota possible biotransformation gastrointestinal tract have not been well reported. To evaluate potential risks at digestive level, completely passing single dose polyethylene terephthalate (PET) through was simulated by combining harmonized static model dynamic simgi model, which recreates different regions...
The microbial populations of the human intestinal tract and their relationship to specific diseases have been extensively studied during last decade. However, characterization bile microbiota as a whole has hampered by difficulties in accessing biological samples lack adequate methodologies assess molecular studies. Although few reports described biliary some hepatobiliary diseases, healthy individuals not described. With this mind, goal present study was generate fundamental knowledge on...
Interactions between food components during their gastrointestinal digestion are constant and could affect compounds digestibility bioaccessibility. These interactions have a key role in the bioactivity of dietary polyphenols. This study aimed to investigate matrix effects co-digestion red wine with glucose whey proteins using dynamic simulator simgi®. Bioaccessibility polyphenols nutrients effect on colonic microbiota composition metabolism were evaluated. Co-digestion led reduction over...
The accumulation of microplastics (MPs) in the environment as well their presence foods and humans highlight urgent need for studies on effects these particles humans. Polylactic acid (PLA) is most widely used bioplastic food industry medical field. Despite its biodegradability, biocompatibility, "Generally Recognized As Safe" (GRAS) status, recent animal model have shown that PLA MPs can alter intestinal microbiota; however, to date, no been reported possible gut health consequences intake...
This paper investigates the mutual interactions between lipids and red wine polyphenols at different stages of gastrointestinal tract by using simgi® dynamic simulator. Three food models were tested: a Wine model, Lipid model (olive oil + cholesterol) (red olive cholesterol). With regard to polyphenols, results showed that co-digestion with slightly affected phenolic profile after digestion. In relation lipid bioaccessibility, tended increase percentage bioaccessible monoglycerides, although...
Little is known about the bacteria that reside in human gallbladder and mechanisms allow them to survive within this harsh environment. Here we describe interactions between two strains from a bile sample, one Ruminococcus gauvreauii (IPLA60001), belonging Lachnospiraceae family, other, designated as Ruminococcoides bili (IPLA60002T; DSM 110008) most closely related bromii family Ruminococcaceae. We provide evidence for salt resistance sporulation these new strains. Both differed markedly...
Grape pomace (GP) is a winemaking by-product rich in polyphenols and fibre. Supplementation with GP extracts has shown potential benefits against oxidative stress- inflammation-related pathologies. As new nutritional target, this paper explores the impact of ingestion grape extract on intestinal barrier functionality. A was sequentially subjected to gastrointestinal colonic digestion using dynamic simulator (simgi®). This generated two simulated fluids: intestinal-digested (IDE)...
Recent dietary habits and lifestyle could explain the shaping of gut microbiota composition and, in consequence, increasing prevalence certain pathologies. However, little attention has been paid to influence diet on microbiotas, other than microbiota. This is important cholelithiasis, given that changes production bile acids may affect gallbladder microbial communities. Our aim was assess association between regular intake composition. Fourteen adults with cholelithiasis 14 controls,...
This paper explores the effects of wine polyphenols on intestinal permeability in vitro conditions. A red (2500 mg/L gallic acid equivalents) was sequentially subjected to gastrointestinal and colonic digestion Dynamic Gastrointestinal Simulator (simgi®) obtain two simulated fluids: intestinal-digested (IDW) colonic-digested (CDW). The fluids were incubated with Caco-2 cell monolayers grown Transwell® inserts, paracellular measured as transport FITC-dextran. Non-significant decreases (p >...
A strictly anaerobic, resistant starch-degrading, bile-tolerant, autolytic strain, IPLA60002T, belonging to the family Ruminococcaceae, was isolated from a human bile sample of liver donor without hepatobiliary disease. Cells were Gram-stain-positive cocci, and 16S rRNA gene whole genome analyses showed that Ruminococcus bromii phylogenetically closest related species novel strain though with average nucleotide identity values below 90 %. Biochemically, new isolate has metabolic features...
Scope This paper explores the effects of moderate red wine consumption on clinical status and symptomatology patients with ulcerative colitis (UC), including study oral intestinal microbiome. Methods results A case control intervention in UC is designed. Intervention ( n = 5) consume (250 mL day −1 ) for 4 weeks whereas do not. Moderate significantly p < 0.05) improves some parameters related to serum iron, alleviates symptoms as evaluated by IBDQ‐32 questionnaire. 16S rRNA gene...
Beer is a source of bioactive compounds, mainly polyphenols, which can reach the large intestine and interact with colonic microbiota. However, effects beer consumption in gastrointestinal function have scarcely been studied. This paper reports, for first time, vitro digestion its impact on intestinal microbiota metabolism. Three commercial beers different styles were subjected to using simgi® model, digested fluids further fermented triplicate faecal from healthy volunteer. The effect human...
Bacteria-host interactions are mediated by different microbial associated molecular patterns which most often surface structures such as, among others, exopolysaccharides (EPSs). In this work, the capability of two isogenic EPS-producing Bifidobacterium animalis subsp. lactis strains to modulate gut microbiota healthy mice, was assessed. Each strain produces a type polymer; ropy S89L synthesized rhamnose-rich, high-molecular weight EPS in highest abundance than non-ropy DMS10140 one. BALB/c...
<sec> <title>BACKGROUND</title> Mobile Health (mHealth) represents a promising instrument for optimizing symptom management and important lifestyle strategies that enhance self-care the quality of healthcare cancer patients. The ALIBIRD mHealth is digital health solution specifically designed telemonitoring oncology patients, fostering patient empowerment supporting clinical decision-making. </sec> <title>OBJECTIVE</title> primary objective this study was to evaluate experience with...
Background SARS-CoV-2 and COVID-19 are still active in the population. Some patients remained PCR-positive for more than 4 weeks, called “persistently PCR-positive”. Recent evidence suggests a link between gut microbiota susceptibility to COVID-19, although no studies have explored persistent PCR conditions. We aimed evaluate relationship positive RT-PCR, microbiome, individual host determinants. Methods A shotgun metagenomic analysis was conducted on fecal samples from 28 individuals...
The impact of the nonbioaccessible fraction two phenolic-rich extracts from Achillea millefolium L. (yarrow) and Origanum majorana (marjoram) on modulation human gut microbiota was investigated in vitro. Microbial metabolism phenolic compounds also addressed. In general, acids or O-glycosidic flavones quickly disappeared, contrast to methoxy- C-glycosidic flavonoids. This colonic yielded phloroglucinol, 3,4-dimethoxyphenylacetic acid, 3-(4-hydroxyphenyl)-propionic 4-hydroxybenzoic acid as...
Gallbladder metagenome involves a wide range of unidentified sequences comprising the so-called metagenomic dark matter. Therefore, this study aimed to characterise three gallbladder metagenomes and fosmid library with an emphasis on matter fraction. For purpose, novel data analysis strategy based combination remote homology molecular modelling has been proposed. According results obtained, several protein functional domains were annotated in fraction including acetyltransferases, outer...
El feminismo y el Derecho Internacional conforman un par relativamente reciente. Si bien existe una tendencia a enmarcar la interseccion entre ambos en ambito de los derechos las mujeres, lo cierto es que va mas alla reclamaciones derechos. nos situa marco relaciones poder genero afectan no solo sino tambien toda sociedad. En situaciones conflicto se revela como interesante herramienta analisis ensena existen potentes roles posibilitan guerras condicionan paz.
Abstract The gut microbiota has emerged as a key factor in the pathogenesis of intestinal viruses, including enteroviruses, noroviruses and rotaviruses (RV), where stimulatory inhibitory effects on infectivity have been reported. With aim determining whether members interact with RV during infection, combination anti-RV antibody labelling, fluorescence-activated cell sorting 16S rRNA amplicon sequencing was used to characterize interaction between specific bacteria stool samples children...