A5100450754- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Microbial Metabolic Engineering and Bioproduction
- Biopolymer Synthesis and Applications
- Gut microbiota and health
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Medicinal Plant Pharmacodynamics Research
- Sulfur Compounds in Biology
- Enzyme Catalysis and Immobilization
- Bacterial Genetics and Biotechnology
- Cholesterol and Lipid Metabolism
- Ginseng Biological Effects and Applications
- Gene expression and cancer classification
- Protein Hydrolysis and Bioactive Peptides
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- Meat and Animal Product Quality
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Chemical Synthesis and Analysis
- Pesticide and Herbicide Environmental Studies
Fujian University of Traditional Chinese Medicine
2012-2025
West China Hospital of Sichuan University
2025
Sichuan University
2025
Central South University of Forestry and Technology
2022-2024
Central South University
2022-2024
Beijing Normal University
2023-2024
Lanzhou University
2024
Dalian Polytechnic University
2023
North Sichuan Medical University
2023
Army Medical University
2022
Oyster (<i>Crassostrea gigas</i>), the main ingredient of oyster sauce, has a strong umami taste. In this study, three potential peptides, FLNQDEEAR (FR-9), FNKEE (FE-5), and EEFLK (EK-5), were identified screened from alcoholic extracts gigas</i>) using nano-HPLC-MS/MS analysis, iUmami-Scoring Card Method (iUmami-SCM) database molecular docking (MD). Sensory evaluation electronic tongue analysis further used to confirm their tastes. The threshold peptides ranged 0.38 0.55 mg/mL. MD with...
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types human cancers; therefore it major focus the development novel anti-cancer agents. Hedyotis diffusa Willd has been used as component several Chinese medicine formulas for clinical treatment colorectal cancer (CRC). However, precise mechanism its anti-tumor activity remains largely unclear. Using CRC mouse xenograft model, present study we evaluated effect ethanol...
Soy sauce is a well-known condiment worldwide. However, the high salt content in soy contributes to intake of sodium salt, which usually results blood pressure. High has better quality (aroma and taste) than low salt. Tetragenococcus halophilus Candida versatilis are important starters for fermentation. It urgent need explore what effect these two strains on aroma- taste-attributes achieve fermentation with salt.In this study, aroma-active taste compounds were reviewed listed. Then,...
5-Fluorouracil (5-FU)-based chemotherapy often causes several drawbacks including weight loss, diarrhea, myelosuppression, and the intestinal mucositis. This study aimed to evaluate protective effect of Qingjie Fuzheng Granule (QFG) on 5-FU-induced mucositis in CT-26 tumor-bearing xenograft mice investigated possible molecular mechanism. Tumor models cells were generated BALB/c nude mice, randomly divided into 4 groups control, QFG, 5-FU combined QFG groups. The body weight, volume tumor...
Liensinine(Lien, C37H42N2O6) is an alkaloid compound from plumula nelumbinis that demonstrates antihypertensive effect. The protective effects of Lien on target organs during hypertension are still unclear.This study aimed to understand the mechanism treatment hypertension, with emphasis vascular protection.Lien was extracted and isolated for further study. In vivo model Ang II-induced non-invasive sphygmomanometer used detect blood pressure in out context intervention. Ultrasound abdominal...
To explore the mechanism of Qingda Granules (QDG) for alleviating brain damage in spontaneously hypertensive rats (SHRs). Twelve 5-week-old SHRs were randomized into SHR control group and SHR+QDG treated with QDG by gavage at daily dose 0.9 g/kg 12 weeks. The rats, along 6 age-matched WKY saline only. Blood pressure changes monitored, pathologies neuronal apoptosis cerebral cortex examined HE staining TUNEL staining. Cerebral cortical expressions miR-124 STAT3 mRNA detected using RT-qPCR,...
Acute kidney injury (AKI) is a worldwide clinical burden associated with high morbidity and mortality. Remote ischemic preconditioning (rIPC), brief nonlethal ischemia reperfusion (IR) in remote tissues or limbs, has been used an attempt to protect against AKI, but its underlying signaling pathways not elucidated. In the present study, rIPC protected function pathological mitigated NADPH oxidase 4 (NOX4) upregulation different AKI models (cisplatin, LPS IRI). Furthermore, significantly...
Three unusual diterpenes with rare sarsolenane and capnosane skeletons, namely mililatensols A–C (1–3), were isolated from the South China Sea soft coral Sarcophyton mililatensis, leading to first record of title animal. The structures compounds 1–3 established by extensive spectroscopic analysis comparison literature data. Moreover, absolute configuration 2 was determined TDDFT ECD calculations. In an in vitro bioassay, none showed obvious anti-inflammatory activity on LPS-induced TNF-α...
Abstract In the present study, extraction and purification of saponins from Sapindus mukorossi Gaertn. were examined for effective utilization saponin resource. Saponins extracted S. using water. The conditions water process, including temperature, time, number times extraction, solvent‐material ratio optimized. yield total (TSS) pericarp was 33.41 % its purity in extract 45.71 %. solution further concentrated to 1/6–1/7 original volume, dried yeast BV818 that adapted (SW) screened....
The aim of the work was to determine interactions a set anti-cancer compounds with bovine serum albumin (BSA) using ProteOn XPR36 array biosensor and molecular docking studies. results revealed that total six compounds: gallic acid, doxorubicin, acteoside, salvianolic acid B, echinacoside, vincristine were able reversibly bind immobilized BSA. sensorgrams these globally fit Langmuir 1:1 interaction model for binding kinetics analysis. There significant differences in their affinity BSA,...
Proteinbinder: Bei drei repräsentativen Polyoxometallat(POM)-Verbindungen, z. B. 1 aus der Wells-Dawson-Klasse, wurde eine Wechselwirkung mit dem basischen Fibroblastenwachstumsfaktor (bFGF, rechts) nachgewiesen, die Konformation des Wachstumsfaktors drastisch verändert. POMs sind viel versprechende Leitstrukturen für Verbindungen, möglicherweise neue Wege Entwicklung von Wirkstoffen gegen bFGF-induzierte Angiogenese eröffnen.