A5014349638- Genomics and Phylogenetic Studies
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Environmental DNA in Biodiversity Studies
- Microbial Community Ecology and Physiology
- Cutaneous lymphoproliferative disorders research
- Identification and Quantification in Food
- CAR-T cell therapy research
- Fish Ecology and Management Studies
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Invertebrate Immune Response Mechanisms
- Insect and Arachnid Ecology and Behavior
- RNA Research and Splicing
- Hemispheric Asymmetry in Neuroscience
- Interdisciplinary Research and Collaboration
- Design Education and Practice
- Animal Genetics and Reproduction
- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Cephalopods and Marine Biology
- RNA and protein synthesis mechanisms
- Mollusks and Parasites Studies
- Protist diversity and phylogeny
- Genetic diversity and population structure
Wellcome Sanger Institute
2020-2024
University of Nottingham
2016-2019
University of Hull
2018-2019
Genomics (United Kingdom)
2019
Bangor University
2010-2014
Biodiversity is of crucial importance for ecosystem functioning, sustainability and resilience, but the magnitude organization marine diversity at a range spatial taxonomic scales are undefined. In this paper, we use second-generation sequencing to unmask putatively diverse metazoan biodiversity in Scottish temperate benthic ecosystem. We show that remarkable differences occurred microgeographical refute currently accepted ecological paradigms meiofaunal identity, rank abundance concomitant...
Abstract Environmental DNA offers great potential as a biodiversity monitoring tool. Previous work has demonstrated that eDNA metabarcoding provides reliable information for lake fish monitoring, but important questions remain about temporal and spatial repeatability, which is critical understanding the ecology of developing effective sampling strategies. Here, we carried out comprehensive England's largest lake, Windermere, during summer winter to (1) examine repeatability method, (2)...
Abstract Aim Meiofaunal communities that inhabit the marine benthos offer unique opportunities to simultaneously study macroecology of numerous phyla exhibit different life‐history strategies. Here, we ask: (1) if meiobenthic is explained mainly by dispersal constraints or environmental conditions; and (2) levels meiofaunal diversity surpass existing estimates based on morphological taxonomy. Location UK mainland European coast. Methods Next‐generation sequencing techniques ( NGS ; R oche...
<ns3:p>We present two genome assemblies, each generated from individual female <ns3:italic>Anopheles</ns3:italic> (<ns3:italic>Nyssorhynchus</ns3:italic>) <ns3:italic>darlingi</ns3:italic> (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), wild populations in French Guiana and Peru. The sequences are approximately 180 megabases span. majority of assembly is scaffolded into three chromosomal pseudomolecules with the X sex chromosome assembled. complete mitochondrial genomes were...
Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of cells primarily affecting the skin. The most common form CTCL, mycosis fungoides, can be difficult to diagnose, resulting in treatment delay. We performed single-cell and spatial transcriptomics analysis skin from patients with fungoides-type CTCL an integrated comparative human atlas datasets healthy inflamed revealed co-optation helper 2 (T
Abstract Environmental DNA offers great potential as a biodiversity monitoring tool. Previous work has demonstrated that eDNA metabarcoding provides reliable information for lake fish monitoring, but important questions remain about temporal and spatial repeatability, which is critical understanding the ecology of developing effective sampling strategies. Here, we carried out comprehensive England’s largest lake, Windermere, during summer winter to 1) examine repeatability method, 2) compare...
<ns4:p>We present a genome assembly from an individual female <ns4:italic>Anopheles gambiae</ns4:italic> (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), Ifakara strain. The sequence is 264 megabases in span. Most of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.</ns4:p>
<ns3:p>We present a genome assembly from an individual female <ns3:italic>Anopheles gambiae</ns3:italic> (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), Ifakara strain. The sequence is 264 megabases in span. Most of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.</ns3:p>
We present a genome assembly from an individual female Anopheles funestus (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae). The sequence is 251 megabases in span. majority of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.
Abstract Cutaneous T-cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The most common form CTCL, mycosis fungoides (MF), can be difficult to diagnose resulting in treatment delay. pathogenesis CTCL not fully understood due limited data from patient studies. We performed single-cell RNA sequencing and spatial transcriptomics profiling skin patients with MF-type an integrated comparative analysis human cell atlas datasets healthy skin,...
<ns3:p>We present a genome assembly from an individual female <ns3:italic>Omphaloscelis lunosa</ns3:italic> (the Lunar Underwing; Arthropoda; Insecta; Lepidoptera; Noctuidae). The sequence is 661.9 megabases in span. Most of the scaffolded into 32 chromosomal pseudomolecules, including W and Z sex chromosomes. mitochondrial has also been assembled 15.47 kilobases length. Gene annotation this on Ensembl identified 18,931 protein coding genes.</ns3:p>
We present a genome assembly from an individual female
We present a genome assembly from an individual female Anopheles maculipalpis (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae). The sequence is 224 megabases in span. Most of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.
<ns3:p>We present genome assembly from individual female <ns3:italic>An. coustani</ns3:italic> (African malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae) Lopé, Gabon. The sequence is 270 megabases in span. Most of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled for both species. complete mitochondrial was also and 15.4 kilobases length.</ns3:p>
<ns3:p>We present a genome assembly from an individual male <ns3:italic>Anopheles nili</ns3:italic> (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), wild population in Cameroon. The sequence is 195 megabases span. Most of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.</ns3:p>
ABSTRACT Although the pond snail Lymnaea stagnalis is an emerging model organism for molecular studies in a wide variety of fields, there are limited number verified endogenous control genes use quantitative real-time PCR. As part larger study on chirality, or left–right asymmetry, we assayed gene expression embryos. We evaluated six candidate genes, by comparing their three tissues (ovotestis, foot and embryo) used software programmes (geNorm, Normfinder Bestkeeper) to do so. The specific...
<ns4:p><ns4:bold>We present a genome assembly from an individual female <ns4:italic>Anopheles funestus</ns4:italic> (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae). The sequence is 251 megabases in span. majority of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.4 kilobases length.</ns4:bold></ns4:p>
We present a genome assembly from an individual male Anopheles moucheti (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), wild population in Cameroon. The sequence is 271 megabases span. majority of the scaffolded into three chromosomal pseudomolecules with X sex chromosome assembled. complete mitochondrial was also assembled and 15.5 kilobases length.
ABSTRACT Although the pond snail Lymnaea stagnalis is an emerging model organism for molecular studies in a wide variety of fields including development, biomineralisation and neurophysiology, there are limited number verified endogenous control genes use quantitative real-time PCR (qRT-PCR). As part larger study on chirality or left-right asymmetry, we wished to assay relative gene expression embryos, so evaluated six new candidate genes, by comparing their three tissues (ovotestis, foot,...
One-step metabarcoding PCR. Used to amplify either mitochondrial 12S or cytochrome B regions from environmental DNA sampled freshwater identify fish species. PCR product contains the sequencing primers ready for on Illumina MiSeq (custom oligos required sequencing).