A5082425534- Dendrimers and Hyperbranched Polymers
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Antimicrobial agents and applications
- Virology and Viral Diseases
- CRISPR and Genetic Engineering
- Lanthanide and Transition Metal Complexes
- Genetically Modified Organisms Research
- Fuel Cells and Related Materials
- vaccines and immunoinformatics approaches
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Legionella and Acanthamoeba research
- Synthesis and properties of polymers
- Forensic Toxicology and Drug Analysis
- Prion Diseases and Protein Misfolding
- HIV Research and Treatment
- Microfluidic and Capillary Electrophoresis Applications
- DNA and Nucleic Acid Chemistry
- Genetics, Bioinformatics, and Biomedical Research
- Ferrocene Chemistry and Applications
- Trace Elements in Health
Institute of Mathematical Sciences
2017
Material Physics Center
2017
Universidad de La Laguna
2017
Universidad de Alcalá
2009-2014
Leibniz Institute of Polymer Research
2013
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2011-2012
Leibniz Association
2012
A new family of amine- and ammonium-terminated carbosilane dendrimers the type Gn-[Si(CH2)3N(Et)CH2CH2NMe2]x Gn-{[Si(CH2)3N+R(Et)CH2CH2N+RMe2]x(X−)y} (where n = 1, 2 3; R H, X Cl; Me, I) respectively has been synthesized by hydrosilylation N,N-dimethyl-N′-allyl-N′-ethyl-ethylenediamine, [(CH2CH–CH2)(Et)N(CH2)2NMe2] with corresponding hydride-terminated subsequent quaternization HCl or MeI. Quaternized are soluble stable in water other protic solvents for long time periods. The antibacterial...
Anionic carbosilane dendrimers of generations 1–3 have been synthesized containing carboxylate GnX(C2H4CO2Na)m and sulfonate GnX(C2H4SO3Na)m peripheral groups derived from two different cores, 1,3,5-(HO)3C6H3 (X = O3) Si(C3H5)4 Si). The anionic make these water soluble, despite their highly hydrophobic framework. These present a net negative charge in water, which was influenced by the pH medium. This characteristic studied titration. Also molecular modeling calculations performed to study...
Here we present a synthetic procedure for water-stable carbosilane dendrimers containing ammonium groups at the periphery of type Gn-{[Si(CH2)3N+(Me)(Et)CH2CH2N+Me3]x (CF3SO3 -)y} which have been used as non-viral vectors transfecting different types nucleic acids against two medical problems, HIV and hepatocarcinoma. These systems shown to be non-toxic in both PBMC HepG2 cell lines under experimental conditions are able form nanoconjugates with perfectly stable over time wide range pH...
A panel of repetitively branched synthetic molecules known as dendrimers is used to identify and differentiate between different strains the prion infectious agent, protein-based pathogen responsible for disorders—a group invariably fatal neurodegenerative diseases.
The influence of the chain length on topology and luminescence four new cadmium(<sc>ii</sc>) R-malonate coordination polymers is analysed herein.
A synthetic strategy has been carried out to prepare a new family of dendrimers containing eugenol linkers between the carbosilane scaffold and peripheral amine or ammonium groups, type Gn-[Si(CH2)3C6H3(OMe){O(CH2)2NMe2}]m Gn-[Si(CH2)3C6H3(OMe){O(CH2)2NMe3+I−}]m respectively. Cationic have shown fluorescent properties due presence aromatic rings. preliminary study interaction with two model drugs as examples Active Pharmaceutical Ingredients (APIs) performed by fluorescence NMR methods. This...
The capillary electrophoresis with UV detection was employed for protein profiling in extracts from maize and soybeans.Modifications of back-ground electrolyte coating the wall polybrene order to decrease adsorption on walls.The obtained profiles were compared transgenic non-transgenic variants, showing some cases significant changes that might be identification genetic modifications plants or foods plant origin.(