A5103010269- Dendrimers and Hyperbranched Polymers
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Organometallic Complex Synthesis and Catalysis
- Antimicrobial agents and applications
- Advanced biosensing and bioanalysis techniques
- Synthesis and characterization of novel inorganic/organometallic compounds
- Organoboron and organosilicon chemistry
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Asymmetric Hydrogenation and Catalysis
- Coordination Chemistry and Organometallics
- Gold and Silver Nanoparticles Synthesis and Applications
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Carbon dioxide utilization in catalysis
- Crystallography and molecular interactions
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Microplastics and Plastic Pollution
- Ferrocene Chemistry and Applications
- biodegradable polymer synthesis and properties
- Enzyme Catalysis and Immobilization
Universidad de Alcalá
2016-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Instituto Cajal
2019-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2019-2025
Instituto de Salud Carlos III
2016-2023
Instituto de Química Médica
2023
Instituto de Química Orgánica General
2016-2020
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2019
Adam Mickiewicz University in Poznań
2019
AGH University of Krakow
2019
The transcription factor nuclear erythroid 2-related 2 (Nrf2) is considered as the master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a pivotal role in cancer progression. Nrf2 mediates adaptive response which contributes to resistance chemotherapeutic pro-oxidant drugs, such cisplatin (CDDP), various tumors, including bladder cancers. For this reason, could be promising target overcome chemoresistance. There are several known pharmacological inhibitors;...
Cationic carbosilane dendrimers of generations 1–3 have been synthesized employing thiol–ene click chemistry. The obtained present three different types ammonium functions, two them with the charge at surface, –NH3+ and –NMe3+, other internalized by presence ethylalcohol moieties, –[NMe2(CH2CH2OH)]+. influence –NMe3+ –[NMe2(CH2CH2OH)]+ in dendrimer structure studied molecular dynamics. antibacterial properties these families evaluated against Gram-positive (Staphylococcus aureus CECT 240)...
The purpose of this research was to determine the potential use water-soluble anionic and cationic carbosilane dendrimers (generations 1–3) as mucoadhesive polymers in eyedrop formulations. Cationic decorated with ammonium –NH3+ groups were prepared by hydrosylilation Boc-protected allylamine followed deprotection HCl. Anionic terminal carboxylate also employed study. In vitro vivo tolerance studies performed human ocular epithelial cell lines rabbit eyes respectively. interaction...
The bactericidal activity of a library cationic dendritic systems depends on the hydrophilic/hydrophobic structural balance, being presence sulfur atom proximal to peripheral ammonium functions relevance.
The search for new microbicide compounds is of an urgent need, especially against difficult-to-eradicate biofilm-forming bacteria. One attractive option the application cationic multivalent dendrimers as antibacterials and also carriers active molecules. These require adequate hydrophilic/hydrophobic structural balance to maximize effect. Herein, we evaluated antimicrobial activity carbosilane (CBS) unmodified or modified with polyethylene glycol (PEG) units, planktonic P. aeruginosa...
A new family of amine- and ammonium-terminated hyperbranched polycarbosilanes (PCS) dendrimers has been synthesized. The functionalization a polycarbosilane matrix was carried out with peripheral allyl groups by two strategies in the case PCS: 1) hydrosilylation amines PCS containing terminal Si–H bonds, or 2) PCS–allyl an aminosilane. Dendrimers amine were synthesized allydimethylamine. Quaternized systems MeI are soluble stable water other protic solvent. antibacterial properties have...
A variety of neutral and cationic carbosilane dendrons containing a wide range active groups, such as −N3, −OH, −NH2, −SH, at the focal points were synthesized from vinyl BrGnVm generations 1–3 by substitution bromine atom point functionalization groups via thiol-ene click chemistry with HS(CH2)2NMe2·HCl. These dendritic wedges characterized NMR, MS, elemental analysis.
Anionic carbosilane dendrimers of generations 1–3 have been synthesized containing carboxylate GnX(C2H4CO2Na)m and sulfonate GnX(C2H4SO3Na)m peripheral groups derived from two different cores, 1,3,5-(HO)3C6H3 (X = O3) Si(C3H5)4 Si). The anionic make these water soluble, despite their highly hydrophobic framework. These present a net negative charge in water, which was influenced by the pH medium. This characteristic studied titration. Also molecular modeling calculations performed to study...
Abstract A novel nanosystem based on mesoporous silica nanoparticles covered with carbosilane dendrons grafted the external surface of is reported. This system able to transport single‐stranded oligonucleotide into cells, avoiding an electrostatic repulsion between cell membrane and negatively charged nucleic acids thanks cationic charge provided by dendron coating under physiological conditions. Moreover, presence highly ordered pore network inside matrix would make possible allocate other...
Anionic carbosilane dendrons decorated with sulfonate functions and one thiol moiety at the focal point have been used to synthesize water-soluble gold nanoparticles (AuNPs) through direct reaction of dendrons, precursor, reducing agent in water, also a place-exchange reaction. These characterized by NMR spectroscopy, TEM, thermogravimetric analysis, X-ray photoelectron spectroscopy (XPS), UV/Vis elemental zeta-potential measurements. The interacting ability anionic was investigated EPR...
As bacterial resistance to antibiotics increases, there is an urgent need identify alternative antibacterial agents and improve materials. One the controlled transport of that prevents infection with drug-resistant bacteria, especially in treatment difficult-to-heal wounds. This work presents use electrospun PLCL/PVP (poly(L-lactide-co-ε-caprolactone/polyvinylpyrrolidone) nanofibers modified two properties but different mechanisms action, is, dendritic silver nanoparticles (Dend-AgNPs)...
Antimicrobial proteins, like lysozymes produced by animals or bacteriophage lysins, enable the degradation of bacterial peptidoglycan (PG) and, consequently, lead to cell lysis. However, activity those enzymes is not satisfactory against gram-negative bacteria because presence an outer membrane (OM) barrier. Lytic can therefore be combined with membrane-disrupting agents, such as dendritic silver nanoparticles. Nevertheless, a lipopolysaccharide (LPS), especially smooth type, could main...
The terminal chloroaminophosphido complex [Co(CO)3(PPh3){P(Cl)NiPr2}] is formed via reaction of K[Co(CO)4] with iPr2NPCl2 in the presence triphenylphosphine. Chloride abstraction by aluminum trichloride leads to first phosphinidene cobalt, [Co(CO)3(PPh3)(PNiPr2)][AlCl4]. electrophilicity was demonstrated its diphenylacetylene form phosphirene [Co(CO)3(PPh3){P(NiPr2)C(Ph)C(Ph)}][AlCl4].
[TaCp*Cl2{N(2,6-Me2C6H3)}] reacts with 2 equiv of LiMe at −78 °C to give the imido dimethyl complex TaCp*Me2{N(2,6-Me2C6H3)} (1) in almost quantitative yield, whereas monomethyl derivatives [TaCp*MeX{N(2,6-Me2C6H3)}] (X = Cl (2), OC6H3Me2 (3)) can be prepared by addition HX Cl, OC6H3Me2) toluene solutions [TaCp*Me(NR){NR(CMeCMe2)}] (R 2,6-Me2C6H3) elimination corresponding imine RNCMeCHMe2. Complex 1 CO dinuclear ene diolate [TaCp*{N(2,6-Me2C6H3)Me}]2{μ-η2-OC(Me)C(Me)O} (5) via...
Gold nanoparticles (AuNPs) and polycationic macromolecules are used as gene carriers. Their behaviour is dependent on several factors, such the size type of framework, charge, etc. We have combined both types systems prepared AuNPs covered with cationic carbosilane dendrons aim to evaluate their biocompatibility. Water soluble dendronized were following a straightforward procedure from dendrons, gold precursor reducing agent in water characterized by 1H NMR, transmission electron microscopy...