A5067450361- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Advanced Drug Delivery Systems
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Dendrimers and Hyperbranched Polymers
- Hormonal Regulation and Hypertension
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Retinal and Macular Surgery
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Drug Solubulity and Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- biodegradable polymer synthesis and properties
- Dysphagia Assessment and Management
- Advancements in Transdermal Drug Delivery
- Drug-Induced Ocular Toxicity
- Nerve injury and regeneration
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- E-Learning and Knowledge Management
- Neurological Disorders and Treatments
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2016-2025
Universidad Complutense de Madrid
2016-2025
Hospital Clínico San Carlos
2020-2025
Instituto de Salud Carlos III
2016-2024
Centro de Investigación Biomédica en Red
2021
Université Paris-Sud
2006-2008
Centre National de la Recherche Scientifique
2006-2008
Universidad de Sevilla
2002-2007
Université Paris Cité
2007
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2006
Abstract Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces signs CNV treatment. In animal models AMD, pharmacological inhibition MR pathway or endothelial-specific deletion inhibits through VEGF-independent mechanisms, part...
The purpose of this research was to determine the potential use water-soluble anionic and cationic carbosilane dendrimers (generations 1–3) as mucoadhesive polymers in eyedrop formulations. Cationic decorated with ammonium –NH3+ groups were prepared by hydrosylilation Boc-protected allylamine followed deprotection HCl. Anionic terminal carboxylate also employed study. In vitro vivo tolerance studies performed human ocular epithelial cell lines rabbit eyes respectively. interaction...
The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on PLGA-PEG-PLGA (PLGA = poly-(DL-lactic acid co-glycolic acid); PEG polyethylene glycol) deliver neuroprotective agents the retina over time. Two PLGA-PEG PLGA copolymers with different PEG:LA:GA ratios (1:1.54:23.1 and 1:2.25:22.5) for HyG-1 HyG-2 development respectively were synthetized characterized by techniques (gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), dynamic light...
Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site action. The purpose this work was to assess efficacy intravitreal controlled delivery tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres treatment retina a rat model retinitis pigmentosa. PLGA (MSs) containing TUDCA were produced by O/W emulsion-solvent evaporation technique. Particle size...
The increment in ocular drug bioavailability after topical administration is one of the main challenges pharmaceutical technology. For several years, different strategies based on nanotechnology, hydrogels or implants have been evaluated. Nowadays, tolerance ophthalmic preparations has become a critical issue and it essential to use well tolerated excipients. In present work, we explored potential gelatin nanoparticles (GNPs) loaded with timolol maleate (TM), beta-adrenergic blocker widely...
Excitotoxicity has been linked to the pathogenesis of several serious degenerative ocular diseases. Long-term overactivation NMDA receptor by glutamate in retinal ganglion cells (RGCs) results degeneration, apoptosis and loss function leading blindness. antagonists have proposed as a pharmacological blockage excitotoxicity. However, an inhibition pathway activated receptors intolerable side effects. An interesting alternative would be use antiapoptotic compounds RGCs’ neuroprotective active...