A5058726922- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Retinal Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Otitis Media and Relapsing Polychondritis
- Retinal Development and Disorders
- MRI in cancer diagnosis
- Nuclear Structure and Function
- Digital Radiography and Breast Imaging
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Endoplasmic Reticulum Stress and Disease
- Genetic and Kidney Cyst Diseases
- Prostate Cancer Treatment and Research
- Genetic Syndromes and Imprinting
- Mitochondrial Function and Pathology
- Renal Diseases and Glomerulopathies
- Cellular Mechanics and Interactions
- Hedgehog Signaling Pathway Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammasome and immune disorders
- Breast Cancer Treatment Studies
- Cell Image Analysis Techniques
University of the West of England
2017-2025
Durham University
2006-2023
Southmead Hospital
2020
North Bristol NHS Trust
2015-2020
University of Bristol
2017
Newcastle University
2006
Abstract Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we examine 5hmC changes Results increased metastatic tissue relative the primary colon tumour expression of TET2 TET3 negatively correlated risk for metastasis patients CRC. Genes show KEGG enrichment adherens junctions, cytoskeleton cell migration...
Up-regulated expression of lamin A has been implicated in increased cell invasiveness and mortality colorectal cancer. Here we use quantitative proteomics to investigate regulated changes the cytoskeleton that might underpin motility. Using siRNA knockdown a model line (SW480/lamA) confirm presence promotes an enhanced technique prepare fractions combination with 2D DiGE were able accurately reproducibly detect representation protein species within as low 20%. In total 64 spots displayed...
Abstract Proteins responsive to androgen and anti‐androgen may be involved in the development progression of prostate cancer ultimate failure androgen‐ablation therapy. These proteins represent potential diagnostic therapeutic targets for improved management cancer. We have investigated effect (R1881) (bicalutamide) on androgen‐responsive LNCaP cell line using a quantitative gel‐based proteomic approach. Prior analysis, vitro system was evaluated reproducibility validated by appropriate...
Abstract Colorectal cancer (CRC) is a significant global health burden with rising incidence worldwide. Distinct bacterial populations are associated CRC development and progression, it thought that the relationship between gut bacteria changes during progression from normal epithelium to benign adenoma eventually malignant carcinoma metastasis. This study compared interaction of CRC-associated species Enterotoxigenic Bacteroides fragilis , Enterococcus faecalis Fusobacterium nucleatum one...
Abstract Background The underlying pathways that drive retinal neurogenesis and synaptogenesis are still relatively poorly understood. Protein expression analysis can provide direct insight into these complex developmental processes. aim of this study was therefore to employ proteomic the developing chick retina throughout embryonic (E) development commencing at day 12 through 13, 17, 19 post-hatch (P) 1 33 days. Results 2D mass spectrometric detected an average 1514 spots per gel with 15...
Abstract Introduction Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood with a prevalence around 1 in 1,000. Without appropriate treatment it can have devastating consequences including permanent disability from joint destruction and growth deformities. Disease aetiology remains unknown. Investigation pathology at level synovial membrane required if we want to begin understand molecular biochemical level. The proteome early disease-stage, naive JIA...
Abbreviated breast MRI (abMRI) is being introduced in screening trials and clinical practice, particularly for women with dense breasts. Upscaling abMRI provision requires the workforce of mammogram readers to learn effectively interpret abMRI. The purpose this study was examine diagnostic accuracy after a single day standardised small-group training compare performance experienced full-protocol (fpMRI) interpretation (Group 1) that those without fpMRI experience 2).
Ricinoleic acid is a feedstock for nylon-11 (N11) synthesis which currently obtained from castor (Ricinus communis) oil. Production of this fatty in temperate oilseed crop great commercial interest, but the highest reported level transgenic plant oils 30%, below 90% observed and insufficient exploitation. To identify oil-biosynthetic enzymes inform strategies to improve ricinoleic yields, we performed MudPIT analysis on endoplasmic reticulum (ER) purified developing bean endosperm. Candidate...
Introduction:The aim was to compare the accuracy of standard supplementary views and GE digital breast tomosynthesis (DBT) for assessment soft tissue mammographic abnormalities.Methods: Women recalled further abnormalities were recruited received (typically spot compression views) two-view DBT.The added value DBT in process determined by analysing data collected prospectively unblinded radiologists working up cases.Following anonymisation cases, there also a retrospective multireader...
<h3>Background</h3> A better understanding of the patients9 perspectives is pivotal in development patient-reported outcomes (PROs) vasculitis. <h3>Objectives</h3> To assessed perspective disease amongst cases with Giant Cell Arteritis (GCA) compared to comparator illnesses mimicking large vessel vasculitis (LVV) included Diagnostic and Classification Criteria Vasculitis Study (DCVAS) database. <h3>Methods</h3> Patient Description Illness (PDI) forms were circulated Centres participating...