A5101564915- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Cancer-related molecular mechanisms research
- Digital Holography and Microscopy
- Head and Neck Cancer Studies
- Cardiomyopathy and Myosin Studies
- MicroRNA in disease regulation
- Cellular transport and secretion
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Microfluidic and Bio-sensing Technologies
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Cervical Cancer and HPV Research
- Force Microscopy Techniques and Applications
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
Chang Gung Memorial Hospital
2011-2023
Chang Gung University
2014-2023
Memorial Hospital of South Bend
2004-2022
Taichung Veterans General Hospital
2022
Linkou Chang Gung Memorial Hospital
2021
National Synchrotron Radiation Research Center
2019
Taoyuan Chang Gung Memorial Hospital
2013
Research Center for Applied Science, Academia Sinica
2009
National Chung Cheng University
2005-2008
Molecular Oncology (United States)
2006
Abstract Radiation is generally considered to be an immunosuppressive agent that acts by killing radiosensitive lymphocytes. In this study, we demonstrate the noncytotoxic effects of ionizing radiation on MHC class I Ag presentation bone marrow-derived dendritic cells (DCs) have divergent consequences depending upon whether peptides are endogenously processed and loaded onto molecules or added exogenously. The endogenous pathway was examined using C57BL/6 murine DCs transduced with...
A fibromuscular band has been detected in patients with idiopathic left ventricular tachycardia, and this suggested to be the anatomic substrate for arrhythmia. Whether is a specific tachycardia was systematically evaluated large group of consecutive without tachycardia.Conventional transthoracic two-dimensional echocardiography multiplane transesophageal were performed 18 that responsive calcium blockers (group 1, patients) 40 paroxysmal supraventricular 2, control patients). There 17 men 1...
Abstract Resistance of glioblastoma multiforme to radiotherapy poses a major clinical challenge. Farnesyltransferase inhibitors (FTI), such as R115777, have potential increase radiotherapeutic benefit in this disease, although their mechanism action is unclear. In our study with eight cell lines, the most sensitive ones underwent cycle arrest response FTI treatment. Radiosensitization by FTIs, however, seemed involve other pathways. If R115777 treatment was initiated <6 hours before...
Cardiac amyloidosis is one form of systemic caused by abnormal amyloid fibrils deposited in the extracellular space myocardium causing heart failure because restrictive cardiomyopathy and conduction disturbances. The incidence prevalence cardiac are higher than previously noted, particularly among special populations. most common forms light chain transthyretin cardiomyopathy. Even though more 70% patients with have amyloidosis, diagnosis often delayed, suggesting significant gaps knowledge...
Since previous published studies about second malignant tumors (SMTs) in nasopharyngeal carcinoma (NPC) patients usually included a limited sample size and did not attain consistent results, we conducted large retrospective study cohort of 1,549 to assess the risk SMT NPC following radiotherapy (RT) Taiwan. The follow-up period ranged from 2 16 years, with median 7 years. Thirty-nine developed SMTs during 7,145 person-year [standardized incidence ratio (SIR): 2.8; 95% confidence interval...
Abstract Polymerase gamma ( POLG ) is an enzyme responsible for the replication and repair of mitochondrial DNA. Mutations in may cause variable clinical manifestations, including parkinsonism, epilepsy, cerebellar ataxia, neuropathy, progressive external ophthalmoplegia. However, mutations this gene are rare patients with typical Parkinson's disease (PD). We report a man (current age: 59 years) without any underlying presenting right‐hand tremor at age 39 years, followed by slow movement,...
Transthoracic 2-dimensional (D) echocardiography (echo) is often used to assess tricuspid regurgitation (TR) after implantation of permanent pacemakers. However, its ability define the precise anatomical relationship between valve and pacemaker lead quite limited. This report presents a 58-year-old male with aggravation TR for heart block. Three-D echo precisely depicted entrapment shaft in fused fibrotic septal posterior leaflets. The patient underwent annuloplasty symptoms right failure...
Purpose: One of the promising radiosensitizers is ultrasmall gold nanoparticle (GNP) with a hydrodynamic diameter <3 nm. We studied functionalized GNPs (1.8 nm diameter) coated by polyethylene glycol (PEG) and conjugated cyclic RGDfK (2.6 for targeting alpha(v) beta(3) integrin (αvβ3) in murine ALTS1C1 glioma cell line.Materials methods: investigated uptake, toxicity radiosensitivity GNP–PEG–cRGDfKs cells exposed to protons, kilovoltage photons megavoltage photons. The vitro uptake...
Several risk factors for pacemaker (PM) related complications have been reported. However, no study has investigated the impact of lead characteristics on pacemaker-related complications.Patients who received a new implant from January 1997 to December 2011 were selected Taiwan National Health Insurance Database. This population was grouped according in terms fixation and insulation. The leads early heart perforation analyzed by multivariable logistic regression analysis, while late...
Abstract Background The risk of ischemic heart disease (IHD) due to the impact gonadotropin‐releasing hormone (GnRH) agonists among female patients with breast cancer remains a controversy. Methods Information from Registry for Catastrophic Illness, National Health Insurance Research Database (NHIRD), and Death in Taiwan were analyzed. Female selected Illness January 1, 2000, December 31, 2018. All followed until new‐onset IHD diagnosis, death, or A Kaplan–Meier survival curve was drawn show...
Anaplastic lymphoma kinase (ALK) fusion mutation is more common in younger and never-smoking lung cancer patients. The association of smoking ALK-tyrosine inhibitors (TKIs) on overall survival (OS) treatment-naïve ALK-positive advanced adenocarcinoma remains unclear real-world.This retrospective study evaluated all 33170 patients registered the National Taiwan Cancer Registry from 2017 to 2019, whom 9575 stage had ALK data.Among patients, 650 (6.8%) with median follow-up time 30.97 months...
We combine the differential height measurement concept with structured illumination microscopy to develop wide-field optical nanoprofilometry. Sub-diffraction-limit lateral resolution and axially sectioning imaging are achieved using a liquid-crystal spatial light modulator. As sample surface is placed into linear region of axial response curve, signal change owing topographic variations provides nanometer depth sensitivity. The profiling accuracy about 0.3 wavelengths 6 nm, respectively....
We measured the membrane topography and dynamics on a living fibroblast by using non-interferometric widefield optical profilometry (NIWOP) technique. With water-immersion objective of 0.75 numerical aperture, our NIWOP system provides depth resolution about 20 nm. The imaging speed could be as high 5 frames/min. directly observed profiled inward propagation ripples near cell edge. To verify if activity was driven underlying cytoskeleton, we changed structure cortex while observing...