A5063905159- Dermatologic Treatments and Research
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Tattoo and Body Piercing Complications
- Laser Applications in Dentistry and Medicine
- Animal Ecology and Behavior Studies
- Body Image and Dysmorphia Studies
- bioluminescence and chemiluminescence research
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Forest Insect Ecology and Management
- Wildlife Ecology and Conservation
- Ocular Infections and Treatments
- Laser-Matter Interactions and Applications
- Insect and Pesticide Research
- Ocular and Laser Science Research
- Entomological Studies and Ecology
- Vascular Malformations and Hemangiomas
- Nail Diseases and Treatments
- Diagnosis and Treatment of Venous Diseases
- Photochemistry and Electron Transfer Studies
- Study of Mite Species
- Antimicrobial agents and applications
- Botany and Plant Ecology Studies
- Forest Ecology and Biodiversity Studies
University Hospital Regensburg
2016-2025
University of Regensburg
2014-2024
Hautklinik Heidelberg
2012
Arkansas Children's Hospital
2006
United States Food and Drug Administration
2006
Arkansas Department of Agriculture
2006
Technical University of Munich
2002-2005
GTx (United States)
1997
Forstliche Versuchs- und Forschungsanstalt Baden-Württemberg
1990-1993
Bayerisches Staatsministerium für Ernährung, Landwirtschaft und Forsten
1992
New antibacterial strategies are required in view of the increasing resistance bacteria to antibiotics. One promising technique involves photodynamic inactivation bacteria. Upon exposure light, a photosensitizer can generate singlet oxygen, which oxidizes proteins or lipids, leading death. To elucidate oxidative processes that occur during killing bacteria, Staphylococcus aureus was incubated with standard photosensitizer, and generation decay oxygen detected directly by its luminescence at...
Despite of the approval Photofrin® in various countries, chemically defined sensitizers for photodynamic therapy (PDT) are still needed absorption light infrared spectrum, which provides a maximal penetration into tissue. Therefore, both efficacy and mechanism action clinically approved dye indocyanine green (ICG) laser irradiation were investigated vitro. For investigation phototoxic effects, HT-29 cells incubated 24 h prior to by using different concentrations ICG (10–500 μM). In each...
Background and Objective Er:YAG lasers are known to superficially ablate skin other tissues with minimal thermal coagulation zones. The ablation efficacy thus the clinical applicability of these lasers, however, was limited due small beam diameters repetition rates. Aim this study determine amount damage a new high-power high-repetition-rate laser find optimal treatment parameters for ablation. Study Design/Materials Methods: In vitro some in vivo trials on human were performed Er: YAG (MCL...
<i>Background:</i> Millions of people are tattooed. However, the frequency health problems is unknown. <i>Methods:</i> We performed an Internet survey in German-speaking countries. <i>Results:</i> The provenance tattooed participants (n = 3,411) was evenly distributed Germany. had many (28%; >4) and large tattoos (36%; ≧900 cm<sup>2</sup>). After tattooing, described skin (67.5%) or systemic reactions (6.6%). Four weeks after 9% still...
Photodynamic inactivation of bacteria (PIB) proves to be an additional method kill pathogenic bacteria. PIB requires photosensitizer molecules that effectively generate reactive oxygen species like singlet when exposed visible light. To allow a broad application in medicine, photosensitizers should safe applied humans. Substances vitamin B2, which are most likely safe, known produce upon irradiation. In the present study, we added positive charges flavin derivatives enable attachment these...
Prevention and control of biofilm-growing microorganisms are serious problems in public health due to increasing resistances some pathogens against antimicrobial drugs the potential these cause severe infections patients. Therefore, alternative approaches that capable killing needed supplement standard treatment modalities. One is photodynamic inactivation bacteria (PIB). The lethal effect PIB based on principle visible light activates a photosensitizer, leading formation reactive oxygen...
Photodynamic therapy (PDT) is an attractive for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated methyl aminolaevulinate PDT (daylight-PDT) a simple painless treatment procedure PDT. All daylight-PDT studies have been performed in the Nordic countries. To be able to apply these results other parts of world we compare daily protoporphyrin IX (PpIX) light dose countries with PpIX doses found calculate where when AKs was possible six different geographical locations using...
Despite safety concerns regarding the toxicity of tattoo ink, no studies have reported consequences tattooing on immune response. In this work, we characterized transport and accumulation different inks in lymphatic system using a murine model. Upon quick drainage, observed that macrophages mainly capture ink lymph node (LN). An initial inflammatory reaction at local systemic levels follows capture. Notably, process is maintained over time as clear signs inflammation draining LN two months...
Please cite this paper as: Tattoo inks contain polycyclic aromatic hydrocarbons that additionally generate deleterious singlet oxygen. Experimental Dermatology 2010; 19 : e275–e281. Abstract: In the past years, tattoos have become very popular worldwide, and millions of people with mainly black colours. Black tattoo are usually based on soot, not regulated may hazardous (PAHs). Part PAHs possibly stay lifelong in skin, absorb UV radiation oxygen, which affect skin integrity. Therefore, we...
Modern tattoo colourants frequently consist of azo pigments that not only contain multiple impurities but also are originally produced for car paint and the dyeing consumer goods.In order to be able assess health risk tattoos, it is important determine pigment concentration in human skin.We tattooed excised pigskin skin with a common (Pigment Red 22) under various conditions. After tattooing, we quantitatively extracted skin.The ranged from about 0.60 9.42 mg/cm(2) (mean value 2.53 mg/cm(2))...
Millions of people are tattooed with inks that contain azo pigments. The pigments contained in tattoo manufactured for other uses no established history safe use humans and injected into the skin at high densities (2.5 mg/cm(2)). Tattoo disseminate after tattooing throughout human body although some may photodecompose injection site by solar or laser light exposure, extent transport photodecomposition under vivo conditions remains currently unknown. We investigated widely used Pigment Red 22...
Increasing antibiotic resistances in microorganisms create serious problems public health. This demands alternative approaches for killing pathogens to supplement standard treatment methods. Photodynamic inactivation of bacteria (PIB) uses light activated photosensitizers (PS) generate reactive oxygen species immediately upon illumination, inducing lethal phototoxicity. Positively charged phenalen-1-one derivatives are a new generation PS light-mediated with outstanding singlet quantum yield...
We propose an infection-preventive functional material exhibiting a continuous antimicrobial effect upon light irradiation, based on singlet oxygen generation.