Here, we report six novel, easily accessible BODIPY-based agents for cancer treatment. In contrast to established photodynamic therapy (PDT) agents, these compounds show additional photothermal activity and their cytotoxicity is not dependent on the generation of reactive oxygen species (ROS). The high photocytotoxicity upon irradiation with light low dark toxicity in different cell lines 2D culture as well 3D multicellular tumor spheroids (MCTSs). ratio (phototoxic index, PI) reaches...

Quantifiably monitoring sweat rate and volume is important to assess the stress level of individuals and/or prevent dehydration, but despite intense research, a convenient, continuous, low-cost method monitor total loss remains an un-met need. We present here ultra-simple wearable sensor capable measuring accurately. The device continuously monitors by wicking produced into hydrogels that measurably swell in their physical geometry. has been designed as simple fabricate, low-cost, disposable...

Abstract The field of portable healthcare monitoring devices has an urgent need for the development real‐time, noninvasive sensing and detection methods various physiological analytes. Currently, transdermal techniques are severely limited in scope (i.e., measurement heart rate or sweat composition), else tend to be invasive, often needing performed a clinical setting. This study proposes minimally invasive alternative strategy, consisting using dissolving polymeric microneedles deliver...

Vibrational circular dichroism (VCD) spectra were recorded using elliptically polarized ultrashort laser pulses, produced with the help of a photoelastic modulator. The short polarization axis elliptical light acts as phase-locked local oscillator field, heterodyning chiral signal generated by field along long axis. This leads to VCD signals that increase linearly ellipticity probe pulses and enhanced noise, which is expected improve recently reported transient scans. An analogous scheme...

Heterocyclic, macrocycle organic compounds, structurally characterized with porphyrins, are not only abundant in nature but also environmentally friendly. These porphyrinic compounds have recently been extensively studied for their fascinating structures, physical properties, and high potentials engineering applications. We report experimental results on the photonically activated thermal energy conversion via irradiations of white light (simulated solar light). The photothermal effects well...

Laryngeal carcinoma is one of the commonest primary head and neck malignancy need for early identification very important successful treatment. Outpatient fibreoptic examination larynx unreliable in differentiating benign, pre-malignant malignant lesions, therefore surgeons have to rely on biopsies a definitive diagnosis. This an invasive procedure requiring general anaesthesia may detrimental effect patient's voice. Conventional imaging modalities (ultrasound, computed tomography magnetic...

We present an experimental setup to detect transient vibrational circular dichroism signals. A femtosecond laser system is synchronized a photoelastic modulator produce alternating left- and right-handed circularly polarized mid-IR pulses at 1 kHz repetition rate. Transient changes in the of CH-stretch vibrations cobalt-sparteine complex were probed proof-of-principle experiment are clearly distinct from conventional absorption changes.

Abstract Linear dichroism and birefringence artifacts are a major source of concern in transient circular measurements. They mainly arise from interaction an imperfectly polarized probe beam with nonisotropic sample. We present this article procedure to generate mid‐IR pulses highly symmetric left right handed or elliptical polarization states for VCD An infrared femtosecond laser is synchronized the natural frequency photo elastic modulator. Residual static modulator sample cell can be...

Patch testing of contact allergens to diagnose allergic dermatitis (ACD) is a traditional, useful tool. The most important decision the distinction between and irritant reactions, as this has direct implications on diagnosis management. Our objective was evaluate new method non-contact infrared reading patch tests. Secondary objectives included possible correlation intensity test reaction temperature change.420 positive reactions from patients were in our study. An independent reader...

Current clinical methods for the evaluation of lymphatic vessel function, crucial early diagnosis and treatment response several pathological conditions, in particular postsurgical lymphedema, are based on complex mainly qualitative imaging techniques. To address this unmet medical need, we established a simple strategy painless quantitative assessment cutaneous function. We prepared lymphatic-specific tracer formulation, consisting clinically approved near-infrared fluorescent dye,...

We propose a new methodology based on lock-in thermography to study and quantify the heating power of magnetic nanoparticles. Superparamagnetic iron oxide nanoparticles exposed modulated alternating field were used as model materials demonstrate potency system. Both quantitative qualitative information their respective was extracted at high thermal resolutions under increasingly complex conditions, including in liquid, solid aggregated states. Compared conventional techniques, this approach...

Upon dissolution of silver nanoparticles, ions are released into the environment, which known to induce adverse effects. However, since studies predominantly performed in water and/or at room temperature, effects biological media and physiologically relevant temperature on rate not considered. Here, we investigate nanoparticle trends based their plasmonic properties under biologically conditions, i.e. 37 °C over a period 24 h. The studied surface-functionalized with polyvinylpyrrolidone,...

As the skin is an accessible organ and many dermatological diagnostics still rely on visual examination palpation of lesions, dermatology could be dramatically impacted by augmented virtual reality technologies. If emergence such tools raised enormous interest in community, we must admit that have not experienced same breakthrough as they surgery. In this article, investigate status technologies review their current use education, diagnostics, dermatologic surgery; additionally, try to...

Background Lock‐in thermal imaging is a thermographic method that widely used in the nondestructive testing of materials. The technique allows detecting under sample surface, small variations thermophysical properties noninvasive and noncontact manner. Surprisingly, this has, to our knowledge, never been dermatology although it particularly suited. Methods We present article first lock‐in setup dedicated dermatological applications. apparatus uses temperature‐modulated airflow periodically...

Magnetic nanoparticles and their ability to convert electromagnetic energy into heat are of explicit interest for various applications. However, precise quantification heating efficiency is not always upfront, several parameters render comparative studies challenging. This paper describes the theory behind lock-in thermography, a new technique quantifying properties magnetic nanoparticles. allows investigation some potential sources variability: key factors such as field inhomogeneity its...

We present and validate a finite-element model for coupled charge heat transport in monolithically interconnected thin-film solar modules.Using measured current-voltage (I-V) lock-in thermography (LIT) measurements of amorphous silicon minimodules, we experimentally our model.The entire module volume is represented by two planes (front back electrodes) which are vertical direction using 1-D models, leading to large reduction the degrees freedom numerical contributing an efficient solution...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Most methods for monitoring sweat gland activity use simple gravimetric methods, which merely measure the average rate of multiple glands over a region skin. It would be extremely useful to have method could quantify individual in order improve treatment conditions tests as diagnostic tool, such hyperhidrosis, cystic fibrosis, and peripheral nerve degeneration....

There is limited data on the use of digital technologies in outpatient care Switzerland. Our objectives were therefore to determine which are used and whether they had an impact loneliness social isolation wake COVID-19 pandemic.A cross-sectional survey design was with a convenience sample 1272 providers The questionnaire based unsystematic literature review previous qualitative study six caregivers two caring relatives, 30 items for this developed. Data analyzed descriptively, group...

The compositions of sweat and blood are related. Therefore, is an ideal noninvasive test body fluid that could replace for linear detection many biomarkers, especially glucose. However, access to samples remains limited physical exercise, thermal stimulation, or electrical stimulation. Despite intensive research, a continuous, innocuous, stable method stimulation has not yet been developed. In this study, nanomaterial sweat-stimulating gel based on the transdermal drug delivery system...

Abstract Background and Objective Skin thermal diffusivity plays a crucial role in various applications, including laser therapy cryogenic skin cooling.This study investigates the correlation between two important parameters, melanin content erythema, cohort of 102 participants. Methods An in‐house developed device based on transient temperature measurement was used to assess at different body locations. Melanin erythema were measured using colorimeter. Statistical analysis performed examine...