A5058546410- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Inhalation and Respiratory Drug Delivery
- Immunotherapy and Immune Responses
- Nanocluster Synthesis and Applications
- Air Quality and Health Impacts
- Protein Interaction Studies and Fluorescence Analysis
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Plasmonic and Surface Plasmon Research
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Nanomaterials for catalytic reactions
- Advanced Photocatalysis Techniques
- Aquaculture Nutrition and Growth
- Phagocytosis and Immune Regulation
- Electrochemical sensors and biosensors
- Pickering emulsions and particle stabilization
- Spectroscopy Techniques in Biomedical and Chemical Research
- 3D Printing in Biomedical Research
International Iberian Nanotechnology Laboratory
2018-2025
Institut für Nachhaltige Landbewirtschaftung (Germany)
2021-2022
Clinical Academic Center of Braga
2019-2021
University of Fribourg
2014-2020
Adolphe Merkle Institute
2014-2020
University of Bern
2019
Swiss Federal Laboratories for Materials Science and Technology
2019
University of California, Santa Barbara
2019
Federal Department of Economic Affairs, Education and Research
2019
Agroscope
2019
SERS permits identifying the nature of molecules in extremely low concentrations, but it is hindered by poor enhancement or reproducibility. We demonstrate controllable ∼1010 signal amplification reaching zeptomol detection limit for a nonresonant molecule sandwiching analyte between tips star-shaped gold nanoparticles and planar surface using simple synthetic procedure. This unprecedented control over light-intensity opens new avenue toward high-yield, fully reproducible, SERS-based, holds...
Gold nanostars are multibranched nanoparticles with sharp tips, which display extremely interesting plasmonic properties but require optimization. We present a systematic investigation of the influence different parameters on size, morphology, and monodispersity Au obtained via seeded growth in concentrated solutions poly(vinylpyrrolidone) N,N-dimethylformamide. Controlled prereduction Au(3+) to Au(+) was found (narrower plasmon bands), while [HAuCl(4)]/[seed] molar ratio significantly...
Advances in nanophotonics have shown the potential of colloidal metal particles with sharp tips, such as nanostars, to focalize plasmonic electromagnetic fields. We describe this paper performance gold nanostars common surface-enhanced scattering (SES) experiments, including SERS, SERRS, and SEF. The study was carried out for several analytes demonstrated ultradetection nonfunctionalized analytes, by simply depositing on top analyte thin films previously assembled onto a smooth surface.
The synthetic architectures of complex inorganic nanostructures, including multifunctional hollow capsules, are expected to play key roles in many different applications, such as drug delivery, photonic crystals, nanoreactors, and sensing. Implementation novel strategies for the fabrication materials is needed because infancy this knowledge, which still limits progress certain areas. Herein we report a straightforward approach development submicron reactors comprising catalytic gold...
Here we report on the design, synthesis and application of small, highly bright, star-shaped SERS encoded single nanoparticles with ability providing an optical signal upon excitation near infrared light. These particles are colloidally stable, fully biocompatible can be internalized into living cells for intracellular imaging.
Gold nanostars can easily undergo reshaping into spherical particles by simply adding a small amount of CTAB. Such be understood in terms Ostwald ripening involving dissolution weakly bound surface atoms at areas with high convex curvature and re-deposition concave areas. This process stopped any time silver ions, which block bromide stabilize the surface. Because localized plasmon resonance (LSPR) band colloid gradually changes during etching, stabilization intermediate morphologies allows...
The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation NPs. However, date very little is known about factors that pulmonary translocation NPs and their subsequent distribution secondary organs. A novel two-step approach assess biokinetics presented. In a first step, alveolar cellular monolayers (CMLs) at...
Abstract As a highly interdisciplinary field, working with nanoparticles in biomedical context requires robust understanding of soft matter physics, colloidal behaviors, nano-characterization methods, biology, and bio-nano interactions. When reporting results, it can be easy to overlook simple, seemingly trivial experimental details. In this context, we set out understand how vitro technique, specifically the way administer particles 2D culture, influence outcomes. Gold coated...
Surface-enhanced Raman scattering (SERS) spectroscopy can be used for the label-free determination and quantification of relevant small biometabolites that are hard to identify by conventional immunological methods, in absence labelling. In this work, detection is based on monitoring vibrational changes occurring at a specific biointerface (a monoclonal antibody, mAb) supported silver-coated carbon nanotubes (CNT@Ag). Engineered CNT@Ag play key role, as they offer stable substrate support...
Characterization of NPs in physiological and biological fluids is challenging, yet can be met by using depolarized scattering, offering advantages over UV-Vis fluorescence correlation spectroscopy.
We report a systematic study of the surface modification gold and silver nanoparticles with DL-penicillamine (PEN) N-acetyl-DL-penicillamine (NAP), motivated by possibility inducing pH-controlled reversible nanoparticle assembly. The interaction PEN NAP metal was studied isothermal titration calorimetry (ITC). results indicate that equilibrium is reached formation submonolayer corresponding to ca. 40% 64% total coverage for NAP, respectively. Both modified could be reversibly aggregated at...
Facile synthesis of a recyclable magnetic covalent organic framework for the extraction lipophilic marine biotoxins.
Nanocarrier design combined with pulmonary drug delivery holds great promise for the treatment of respiratory tract disorders. In particular, targeting dendritic cells that are key immune to enhance or suppress an response in lung is a promising approach allergic diseases. Fluorescently encoded poly(vinyl alcohol) (PVA)-coated gold nanoparticles, functionalized either negative (−COO–) positive (−NH3+) surface charges, were DC-SIGN antibody on particle surface, enabling binding cell receptor....
Herein, we demonstrated the potential of surface-enhanced Raman scattering (SERS) spectroscopy combined with microfluidics for detection and discrimination foodborne pathogens. SERS-tagged gold nanostars were functionalized a monoclonal antibody specific Listeria monocytogenes. In presence L. monocytogenes, SERS signal corresponding to tag paired was detected in real time continuous flow, enabling monocytogenes innocua just 100 s. To best our knowledge, this is first that tags have been used...
Titanium dioxide (TiO2) and silver (Ag) NPs are among the most used engineered inorganic nanoparticles (NPs); however, their potential effects to marine demersal fish species, not fully understood. Therefore, this study aimed assess proteomic alterations induced by sub-lethal concentrations citrate-coated 25 nm ("P25") TiO2 or polyvinylpyrrolidone (PVP) coated 15 Ag turbot, Scophthalmus maximus. Juvenile were exposed through daily feeding for 14 days. The tested 0, 0.75 1.5 mg of each per kg...
We report the formation of gold nanoparticles with a novel and useful morphology, comprising nanowires fully covered sharp tips (thorned nanowires). The synthesis is based on seeded-growth approach rapid overgrowth ultrathin wires in N,N-dimethylformamide, presence poly(vinylpyrrolidone). process allows fine control over thickness final wires, as well tunability number sharpness thorns. These new plasmonic nanostructures display extremely strong optical enhancing properties can be readily...
In order to harness the unique properties of nanoparticles for novel clinical applications and modulate their uptake into specific immune cells we designed a new library homo- hetero-functional fluorescence-encoded gold (Au-NPs) using different poly(vinyl alcohol) poly(ethylene glycol)-based polymers particle coating stabilization. The encoded particles were fully characterized by UV-Vis fluorescence spectroscopy, zeta potential dynamic light scattering. human monocyte derived dendritic in...