A5078482745- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- Proteoglycans and glycosaminoglycans research
- Inflammasome and immune disorders
- Pulmonary Hypertension Research and Treatments
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Complement system in diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Otitis Media and Relapsing Polychondritis
- Pancreatitis Pathology and Treatment
- Eosinophilic Disorders and Syndromes
- Liver physiology and pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Connective Tissue Growth Factor Research
- Dermatological and Skeletal Disorders
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Ocular Diseases and Behçet’s Syndrome
Children's Hospital of Fudan University
2021-2025
Shanghai Children's Medical Center
2024
Wuhan Children's Hospital
2016-2017
Huazhong University of Science and Technology
2016-2017
Tongji Hospital
2016
Objective To observe the efficacy and safety of telitacicept in refractory childhood-onset systemic lupus erythematosus (cSLE). Methods A self-controlled before–after trial. Children with active SLE, aged 5–18 years, who cannot tolerate side effects glucocorticoid, were enrolled our study. Patients received subcutaneous injection weekly based on standard treatment. SLE responder index-4 (SRI-4) was assessed before first administration at least 4 weeks after administration. Results Among 15...
Abstract Objectives To characterize the clinical features and outcomes of childhood-onset primary Sjögren’s syndrome (pSS). Methods Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists included, all patients applied 2002 American-European Consensus Group (ACEG) criteria, 2016 American College Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for pSS, or 1999 proposed juvenile criteria. The electronic medical records from 2013 to 2020...
Deficiency in ELF4, X-linked (DEX) is a newly identified monogenic autoinflammatory disease. Most reported cases are male, leading to the recognition of DEX being primarily limited male patients. Here we described 3 pediatric female patients with from unrelated families, who all heterozygous for ELF4 mutations (c.320_c.321insA, c.329delA and c.685 A > G). Similar patients, main clinical features include recurring oral ulcers, abdominal pain diarrhea colonoscopy showing ulcers colon....
Juvenile dermatomyositis (JDM) is a systemic autoimmune disease primarily involving the muscles and skin; it can also affect central nervous system (CNS). The relevant literature provides limited information regarding characteristics of JDM with CNS involvement.
Objective To explore the efficacy of initial treatment newly diagnosed childhood-onset lupus nephritis (cLN) with combination belimumab and either cyclophosphamide, mycophenolate mofetil, tacrolimus or multitargeted therapy. Methods A historical control study was conducted on children aged 5–17 years cLN. All patients recruited met 2012 Systemic Lupus International Collaborating Clinics and/or 2019 European League Against Rheumatism/American College Rheumatology classification criteria for...
The pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism Angiopoietin-like protein 3 (ANGPTL3) can alleviate proteinuria symptoms by inhibiting activation integrin αvβ3 on surface podocytes, it not impede other pathological processes, such as dysfunction glucolipid. Interleukin-22 (IL-22) is considered to be a pivotal molecule involved in suppressing responses, initiating regenerative repair,...
In children, focal segmental glomerulosclerosis (FSGS) is the main cause of steroid resistant nephrotic syndrome (SRNS). To identify specific candidates and mechanism resistance, we examined formalin-fixed paraffin embedded (FFPE) renal tissue protein profiles via liquid chromatography tandem mass spectrometry (LC-MS/MS).Renal biopsies from seven steroid-sensitive (SS) eleven steroid-resistant (SR) children FSGS patients were obtained. We (LC-MS/MS). Kyoto Encyclopedia Genes Genomes (KEGG)...
Abstract Proteinuria, an indication of kidney disease, is caused by the malfunction podocytes, which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has been documented to have cell-autonomous involvement and deletion Angptl3 podocytes reduced proteinuria adriamycin-induced nephropathy. Here, we developed monoclonal antibody (mAb) against ANGPTL3 investigate its effects on podocyte injury ADR nephropathy mouse model puromycin (PAN) induced damage vitro....
Angiopoietin-like 3 (ANGPTL3) is a secretory glycoprotein. It has been demonstrated that ANGPTL3 level was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues. Subsequently, our group found closely correlated with nephropathy vivo and vitro. Hence, whether could be the proteinuria level, assessment of disease severity (NS) remained to investigated. This study aimed analyzed correlation between levels serum urine patients proteinuria, assessed patients' disease. In future...
Abstract Objectives To characterize clinical features and outcome of childhood-onset primary Sjögren’s syndrome (pSS). Methods Patients less than 18 years-old, fulfilling the 2002 American-European Consensus Group (ACEG) criteria or 2016 American College Rheumatology/European League Against Rheumatism (ACR/EULAR) for pSS, 1999 proposed Juvenile pSS criteria, were included. Electronic medical records from 2013 to 2020 collected analyzed. Results 39 patients Of them, 27 (69.2%), 38 (97.4%) 35...