Laura M. Paulin
A5083223265- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Smoking Behavior and Cessation
- Asthma and respiratory diseases
- Health disparities and outcomes
- Respiratory Support and Mechanisms
- Air Quality Monitoring and Forecasting
- Noise Effects and Management
- Health and Wellbeing Research
- Obesity, Physical Activity, Diet
- Energy and Environment Impacts
- Pediatric health and respiratory diseases
- Public Health and Nutrition
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Food Security and Health in Diverse Populations
- Obstructive Sleep Apnea Research
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Environmental Justice and Health Disparities
- Behavioral Health and Interventions
- Gut microbiota and health
Dartmouth–Hitchcock Medical Center
2018-2025
Dartmouth College
2019-2025
Dartmouth Hospital
2024
Johns Hopkins University
2008-2021
Johns Hopkins Medicine
2013-2021
Pulmonary and Critical Care Associates
2016-2018
Health First
2017
Hôpital Lyon Sud
2013
Albert Einstein College of Medicine
2010
Montefiore Medical Center
2010
Section:ChooseTop of pageAbstract <<IntroductionWood BurningNatural GasCookingEvaporative VOCsSource ApportionmentRegulatory PoliciesEnvironmental JusticeConclusionsReferences
<ns4:p>Air pollution is a leading cause of morbidity and mortality throughout the world, particularly in individuals with existing lung disease. Of most common air pollutants, particulate matter (PM) associated an increased risk exacerbations respiratory symptoms disease, to lesser extent, those without known issues. The majority published research has focused on effects PM exposures health care utilization. Fewer studies focus impact objective measurements pulmonary function. This review...
The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain.The first longitudinal study to investigate the independent effects particulate matter (PM) and nitrogen dioxide (NO(2)) concentrations COPD a periurban community.Former smokers were recruited was monitored over 1-week period participant's bedroom main living area at baseline, 3 months, 6 months. At each visit, participants...
Rationale: Links between occupational exposures and morbidity in individuals with established chronic obstructive pulmonary disease (COPD) remain unclear.Objectives: To determine the impact of on COPD morbidity.Methods: A job exposure matrix (JEM) determined likelihood based longest current/former smokers (n = 1,075) recruited as part Subpopulations Intermediate Outcomes Study, whom 721 had COPD. Bivariate multivariate linear regression models estimated association COPD, among those disease,...
In developing countries, poor and rural areas have a high burden of chronic obstructive pulmonary disease (COPD), environmental pollutants indoor burning biomass been implicated as potential causal exposures. Less is known about the prevalence COPD in United States with respect to urban-rural distribution, poverty, factors that uniquely contribute among never-smokers.To understand impact status, other community on nationwide never-smokers.We studied nationally representative sample adults...
Chronic obstructive pulmonary disease (COPD) is variable in its development. Lung microbiota and metabolites collectively may impact COPD pathophysiology, but relationships to clinical outcomes milder are unclear.
The airway microbiome has the potential to shape chronic obstructive pulmonary disease (COPD) pathogenesis, but its relationship outcomes in milder is unestablished.
Few studies have investigated the association of long-term ambient ozone exposures with respiratory morbidity among individuals a heavy smoking history.To investigate historical exposure risk chronic obstructive pulmonary disease (COPD), computed tomography (CT) scan measures disease, patient-reported outcomes, severity, and exacerbations in smokers or at for COPD.This multicenter cross-sectional study, conducted from November 1, 2010, to July 31, 2018, obtained data Air Pollution Study, an...
Rationale: There is limited evidence of the effect exposure to heat on chronic obstructive pulmonary disease (COPD) morbidity, and interactive between indoor air pollution has not been established.Objectives: To determine outdoor COPD morbidity whether concentrations modify temperature.Methods: Sixty-nine participants with were enrolled in a longitudinal cohort study, data from 601 participant days that occurred during warm weather season included analysis. Participants completed home...
Rationale: Black adults have worse health outcomes compared with white in certain chronic diseases, including obstructive pulmonary disease (COPD).Objectives: To determine to what degree disadvantage by individual and neighborhood socioeconomic status (SES) may contribute racial disparities COPD outcomes.Methods: Individual neighborhood-scale sociodemographic characteristics were determined 2,649 current or former adult smokers without at recruitment into SPIROMICS (Subpopulations...
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by fixed spirometric ratio, FEV1/FVC < 0.70 after inhaled bronchodilators. However, the implications of variable obstruction (VO), in which prebronchodilator ratio less than but increases to or more bronchodilators, have not been determined. Objectives: We explored differences physiology, exacerbations, and health status participants with VO compared reference without obstruction. Methods: Data from SPIROMICS (Subpopulations...
Nitrogen dioxide (NO2), a by-product of combustion produced by indoor gas appliances such as cooking stoves, is associated with respiratory symptoms in those obstructive airways disease. We conducted three-armed randomized trial to evaluate the efficacy interventions aimed at reducing NO2 concentrations homes unvented stoves: (i) replacement existing stove electric stove; (ii) installation ventilation hood over and (iii) placement air purifiers high-efficiency particulate (HEPA) carbon...
The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin,
It is not certain the extent to which childhood smoking adds chronic obstructive pulmonary disease (COPD) risk independent of lifetime cigarette exposure.
Background Research on cigarettes and adult asthma offers mixed findings, perhaps due to overlap with chronic obstructive pulmonary disease (COPD) inadequate adjustment for other smoke exposures. Associations between tobacco products, including e-cigarettes, are also understudied. question Using Population Assessment of Tobacco Health Study waves 2–4 (2014/2015–2016/2017) data, we assessed the relation product use in persons unlikely have COPD. design methods Prospective study 10 267 adults...
Background Decreased but measurable serum IgA levels (≤70 mg/dL) have been associated with risk for infections in some populations, are unstudied COPD. This study tested the hypothesis that subnormal would be exacerbation Methods Data were analyzed from 1,049 COPD participants observational cohort SPIROMICS (535 (51%) women; mean age 66.1 (SD 7.8), 338 (32%) current smokers) who had baseline measured using Myriad RBM biomarker discovery platform. Exacerbation data was collected prospectively...
Rationale: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and associated with significant burden comorbidities. Although anemia adverse outcomes in COPD, its contribution to individuals other comorbid chronic diseases not well understood.Objectives: This study examines the association large, well-characterized COPD cohort, attempts understand phenotypes comorbidities.Methods: Participants from SPIROMICS (the Subpopulations Intermediate Outcome Measures Study)...
Rationale: Individual socioeconomic status has been shown to influence the outcomes of patients with chronic obstructive pulmonary disease (COPD). However, contextual factors may also play a role. The objective this study is evaluate association between neighborhood disadvantage measured by area deprivation index (ADI) and COPD-related outcomes. Methods: Residential addresses SubPopulations InteRmediate Outcome Measures in COPD Study (SPIROMICS) subjects (FEV 1 /FVC < 0.70) at baseline were...