A5100372095- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- IgG4-Related and Inflammatory Diseases
- Bone Tumor Diagnosis and Treatments
- Renal Diseases and Glomerulopathies
- Pharmacological Effects of Natural Compounds
- Neurological Complications and Syndromes
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- Sarcoma Diagnosis and Treatment
- Folate and B Vitamins Research
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Soft tissue tumor case studies
- Cell Adhesion Molecules Research
- Moyamoya disease diagnosis and treatment
- Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Diagnosis and Treatment of Venous Diseases
- Selenium in Biological Systems
- Laser-Ablation Synthesis of Nanoparticles
- Ocular Infections and Treatments
- Acupuncture Treatment Research Studies
- Asthma and respiratory diseases
First Hospital of Jilin University
2019-2025
Jilin University
2019-2025
Zhongshan Hospital of Xiamen University
2021-2024
North China University of Science and Technology
2024
He Eye Hospital
2024
Creative Commons
2024
China Medical University
2023
Daqing Oilfield General Hospital
2023
Affiliated Hospital of Nantong University
2023
Nantong University
2023
Systemic lupus erythematosus (SLE) is a latent, insidious autoimmune disease, and with the development of gene sequencing in recent years, our study aims to develop gene-based predictive model explore identification SLE at genetic level. First, expression datasets whole blood samples were collected from Gene Expression Omnibus (GEO) database. After merged, they divided into training validation ratio 7:3, where healthy dataset 334 71, respectively, 143 30, respectively. The was used build...
To compare the clinical characteristics of osteoma, ossifying fibroma (OF) and fibrous dysplasia (FD) in paranasal sinus craniofacial regions.Totally 282 patients (112 males, 170 females) with osteoma (161), OF (44), FD (77) involving sinus, skull base orbit treated surgically from January 2012 to August 2018 were analyzed retrospectively.For FD, onset ages 40.3 (6-75), 24.5 (5-62), 15 (1-63) years, most common locations ethmoid (49.7%), maxilla (36.4%) (49.4%), respectively. There...
There have been a few epidemiological studies reporting VDR polymorphisms including Fok1, Bsm1, Apa1 and Taq1with breast cancer incidence therefore risk. The results however are controversial, often due to smaller sample size. Concerning most of the were performed on Caucasian women, we conducted this comprehensive meta-analysis encompassing 38,151 cases 47,546 controls (Fok1: 13,152 cases, 17,443 controls; Bsm1: 14,755 18,633 Apa1: 3080 3412 Taq1: 7164 8068 controls) better understand roles...
Abstract Renal biopsy is the cornerstone of diagnostic approaches in nephrology, as they provide invaluable information. In this study, we analyzed and reported renal results from northeast China past 10 years to describe epidemiological trend. We clinical features, indications, histological diagnoses biopsies collected between January 1, 2007, December 31, 2016. There were 2725 identified cases (with a mean age 41.24 ± 15.18 years, 55% male) during study period. The main indication was...
The purpose of this meta-analysis is to investigate whether statin a key therapy for myocardial infarction (MI) by comparing all randomized controlled trials that appraised the effects on risk MI. Pubmed, Embase, and Medline databases (up December 2016) were used search related articles. Using data from 18 available publications, we examined efficacy in treating or reducing MI using random-effects models odds ratio (OR) highest with lowest category. Statins have demonstrated (OR = 0.73, 95%...
Peritoneal adhesions (PA) are a common and severe complication after abdominal surgery, impacting millions of patients worldwide. The use anti-adhesion materials as physical barriers is an effective strategy to prevent postoperative adhesions. However, the local inflammatory microenvironment exerts significant impact on efficacy therapies. In this study, injectable hydrogel based oxidized dextran/carboxymethyl chitosan (DCC) designed prepared. Furthermore, DCC specifically engineered load...
The role of extracellular vesicles (EVs) derived from inflammatory chondrocytes in EV-based therapy for osteoarthritis (OA) has received little attention. We examined the effects EVs both normal rat (nEVs) and IL-1β-treated (iEVs) on chondrocytes, macrophages, osteoblasts, alongside mRNA-seq miRNA-seq analyses them. Additionally, nEVs iEVs were administered intra-articularly joints models subjected to anterior cruciate ligament transection (ACLT), morphological alterations across assessed....
Traditional Chinese medicine (TCM) has been used successfully to treat rheumatoid arthritis (RA). Qingre Huoxue treatment (Qingre decoction (QRHXD)/Qingre external preparation (QRHXEP)) is a therapeutic scheme of TCM for RA. To date, there have few studies comparing the efficacy and safety QRHXD conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) active This was investigated in multicenter, double-blind, randomized controlled trial involving 468 patients with RA [disease...
Phosphoinositide-specific phospholipases C-γ1 (PLC-γ1) signaling has been shown to modulate osteoarthritis (OA) chondrocyte metabolism. However, the role of PLC-γ1 in OA osteoblasts remains unclear. Herein, whether and how was involved mineralization subchondral bone were investigated.Primary non-OA human rat isolated from or calvaria cultured vitro, as well mouse pre-osteoblastic cell line MC3T3-E1 cells. Rat knee model induced by anterior cruciate ligament transection (ACLT), which canal...
To investigate the clinicopathologic features, immunophenotype, molecular genetic changes, and differential diagnosis of cranial fasciitis (CF).The clinical manifestations, imaging, surgical technique, pathologic characteristics, special staining, as well break-apart fluorescence in situ hybridization assay for USP6 19 CF cases were analyzed, retrospectively.The patients 11 boys 8 girls, aged 5 to 144 months, with a median age 29 months. There (26.31%) temporal bone, 4 (21.05%) parietal 3...
Cerebral palsy (CP) is a group of permanent, but not unchanging, disorders movement and/or posture and motor function. Since the major brain injury associated with CP white matter (WMI), especially, in preterm infants, we established “multi-hit” rat model to mimic human WMI symptomatology at histological level. In our model, pups suffering from limb paresis, incoordination, direction difficulties fit performance CP. Histologically, they present fewer neural cells, inordinate fibers, more...
Introduction . Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases. This study aims to investigate hip synovial tissues ankylosing spondylitis (AS) patients for plasma cells ectopic with germinal centers (GCs). Methods Synovial samples were collected from 7 AS who received total replacement evaluated using immunohistochemistry CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic (FDC), CD38+ cells....
IgG4-related disease (IgG4-RD) is a slowly progressing inflammatory that can involve multiple organ systems. There considerable overlap between IgG4-RDs and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Herein, we present an unusual case of IgG4-associated tubulointerstitial nephritis (IgG4-TIN) ANCA-associated glomerulonephritis (ANCA-GN) co-occurring with C3 (C3GN).A 72-year-old male was admitted to hospital because fever fatigue. He diagnosed elevated serum...
Abstract Rationale: Torsion of the omentum and infarction are rare unusual disorders that often present as acute abdominal pain in population. The diagnosis omental torsion is based on clinical imaging examinations. Patient concerns: A 7-year-old girl presented with right lower quadrant pain, symptoms resembling appendicitis. Diagnosis: patient was diagnosed laparoscopy. Interventions: Laparoscopic exploration performed. Outcomes: discharged seven days after satisfactory postoperative...
A 20-year-old male patient underwent small-incision lenticule extraction (SMILE) due to compound myopic astigmatism in both eyes. On the first day after SMILE, was diagnosed with infectious keratitis (IK) caused by Streptococcus equinus . Emergency surgery performed, and 2.5% vancomycin solution used wash corneal interlamine of After surgery, intensive antibiotic treatment glucocorticoids were administered reduce haze epithelium prevent scar hyperplasia. IK controlled eyes, uncorrected...