A5079319168- Microbial infections and disease research
- MicroRNA in disease regulation
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Toxoplasma gondii Research Studies
- Circular RNAs in diseases
- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- RNA Research and Splicing
- Toxin Mechanisms and Immunotoxins
- Selenium in Biological Systems
- Viral gastroenteritis research and epidemiology
- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Kruppel-like factors research
- Plant-based Medicinal Research
- Sperm and Testicular Function
- RNA modifications and cancer
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Coccidia and coccidiosis research
- Freezing and Crystallization Processes
- Helminth infection and control
Tibet University
2006-2024
Huazhong Agricultural University
2020
Mycobacterium tuberculosis (M. tb) can survive in the hostile microenvironment of cells by escaping host surveillance, but molecular mechanisms are far from being fully understood. MicroRNAs might be involved regulation this intracellular process. By RNAseq M. tb-infected PMA-differentiated THP-1 macrophages, we previously discovered down-regulation miR-378d during tb infection. This study aimed to investigate roles infection using a mimic and inhibitor. First, was confirmed decrease...
The intronic microRNA, miR-125b, plays a vital role in promyelocytic and hematopoietic stem cells, the development apoptosis of cancer cells. In this study, we showed that miR-125b regulates granulosa cell (GC) yak ovary. Bioinformatic analyses luciferase reporter assays demonstrated bone morphogenetic protein receptor type 1B (BMPR1B) is an target. overexpression induced GC, affected mRNA expression BMPR1B ratio Bcl2/Bax. Silencing decreased rate GC increased addition, effects inhibitor...
Porcine circovirus-associated diseases, caused by porcine circovirus type 2 (PCV2), are widespread and result in significant economic losses to the global swine industry. It is generally believed that PCV2 can be divided into nine genotypes (PCV2a PCV2i), with dominant being PCV2d genotype. In this study, 2675 samples from pig farms 13 cities Jiangsu Province, China, were collected between 2014 2021 subjected polymerase chain reaction analysis investigate prevalence genetic diversity of...
Porcine circovirus-associated diseases, caused by porcine circovirus type 2 (PCV2), are widespread and result in significant economic losses to the global swine industry. PCV2 can currently be divided into nine genotypes (PCV2a PCV2i), with dominant one being PCV2d genotype. In this study, 2675 samples from 804 pig farms 13 cities Jiangsu Province, China, were collected between 2014 2021 subjected polymerase chain reaction analysis investigate frequency genetic diversity of PCV2. The results...
<title>Abstract</title> <bold>Background</bold> To enhance Niangya yak's reproductive efficiency and breeding process, this study employed Label-free quantitative proteomics technology to analyze fresh (F) chilled (C) semen samples.<bold>Result</bold> The analysis revealed an extensive repertoire of 18,338 peptide segments 2,579 proteins within yak semen. Among them, 2,300 were successfully annotated in the database. Notably, a total 300 DEPs identified between C F groups; comprising 129...
Mycoplasma bovis (M. bovis) is one of the most important pneumonia pathogens in yaks. It may result more economic losses due to cold and anoxia condition at Qinghai Tibetan plateau. However, date, limited information on M. infection yaks available China. For this purpose, seroprevalence was investigated living mentioned area through commercial ELISA kits. A total 959 were incorporated into study. The prevalence disease 48.70%. serological results revealed a relatively high present study...
Mycoplasma bovis (M. bovis) is one of the important pathogens for yaks. Aminoglycosides and fluoroquinolones are frequently used medications treatment M. bovis. Drug-resistant strains were inevitable with abuse antibiotics. The resistance to aminoglycosides was related base mutations in drug target genes. Amino acid at quinolone resistance-determining region (QRDR) gyrA, gyrB, parC, parE conferred fluoroquinolones. In order investigate mechanism from yaks Tibet fluoroquinolones, six...
Background: Bone morphogenetic protein 15 (BMP15) is an oocyte secretory factor expressed mainly in mammalian oocytes and exerts biological functions through binding to specific receptors on the granulosa/sheath cell membrane.BMP15 regulates development proliferation of granulosa cells (GCs) inhibits follicle stimulating hormone (FSH)-dependent differentiation proliferation.In this report, regulatory mechanism BMP15 yak ovary secretion was examined.Methods: An iodine progesterone...