A5101711494- Erythrocyte Function and Pathophysiology
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Hydrogen's biological and therapeutic effects
- Eosinophilic Disorders and Syndromes
- Neonatal Health and Biochemistry
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Chronic Myeloid Leukemia Treatments
- Nanoparticles: synthesis and applications
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Appendicitis Diagnosis and Management
- Dysphagia Assessment and Management
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Viral-associated cancers and disorders
- Glutathione Transferases and Polymorphisms
Kawasaki Medical School
2015-2024
Okayama Prefecture
2016
Kyushu University
2012-2013
Sakurabashi Watanabe Hospital
2012
Osaka Police Hospital
2012
Fujita Health University
1988
Diastolic late mitral annular velocity (a') measured by transthoracic echocardiography (TTE) is reported to represent left atrial (LA) pump function and the severity of LA remodelling. The purpose this study investigate association between a' blood stasis in patients with non-valvular paroxysmal fibrillation.We enrolled 138 consecutive fibrillation who had spontaneous sinus rhythm at time echocardiography. Using TTE, was determined as an average tissue Doppler velocities septal lateral...
Central nervous system (CNS) relapse is a critical issue while treating Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). A 58-year-old woman with Ph-positive ALL who relapsed after bone marrow transplantation for meningeal was treated high-dose methotrexate, which resulted in remission. She underwent allogeneic cord blood followed by reduced intensity conditioning chemotherapy imatinib; however, she experienced CNS and developed an extramedullary mass on the...
Prolonged exposure to excessive reactive oxygen species (ROS) increases risk factors for many diseases.Therefore, elimination of ROS as well prevention its production becomes critically important.In the present study, we evaluated levels cytotoxicity and scavenging activity induced by synthetic platinum nanoparticles (PtNPs).Average size synthesized PtNPs was 2.2 nm.Synthetic were found scavenge both endogenous H 2 O significantly in L6 rat skeletal muscle cells at a very low concentration...
Myxoid liposarcoma, a rare type of tumor, accounts for approximately 30% all liposarcomas. liposarcomas harboring the FUS/CHOP fusion gene have shown promising results with trabectedin in basic research and some clinical experiments. However, efficacy safety chemotherapy-naive soft tissue sarcomas or gene-positive myxoid not yet been established. Therefore, we evaluated effectiveness monotherapy four cases liposarcoma at our hospital.
Flow cytometric test for analyzing the eosin-5-maleimide (EMA) binding to red blood cells has been believed be a specific method diagnosing hereditary spherocytosis (HS). However, it reported that diseases other than HS, such as pyropoikilocytosis (HPP) and Southeast Asian ovalocytosis (SAO), which are forms in category of elliptocytosis (HE), show decreased EMA cells. We analyzed 101 healthy control subjects 42 HS patients obtained mean channel fluorescence (MCF) cut-off value 36.4...
A 74-year-old man was treated with ceftriaxone for 5 days and subsequently experienced epigastric pain. Computed tomography (CT) performed 7 3 before epigastralgia. Although the first CT image revealed no radiographic signs in his biliary system, second dense radiopaque material gallbladder lumen. The third image, taken at symptom onset, showed high density common bile duct enlargement of pancreatic head. This is a very rare case pseudolithiasis involving duct, as captured on series images.
Herpes zoster (HZ) occurs mostly in elderly and immunocompromised individuals. Immune reconstitution may be associated with the pathogenesis of HZ. As immune checkpoint inhibitor (ICI) treatment amplifies response, use ICI increase incidence There have been few studies HZ lung cancer patients treated ICI. This study was performed to investigate frequency who received or cytotoxic chemotherapeutic agents.We searched electronic medical records for receiving anticancer drug therapy at our...
Purpose: Cure-oriented treatment of malignant lymphoma (ML) is possible even in an advanced stage; however, the progression drug-induced interstitial lung disease (DILD) sometimes accounts for poor clinical outcomes. This study aims to assess incidence and characteristics DILD among patients with ML compares serum level Krebs von den Lungen-6 (KL-6) that circulating thymus activation-regulated chemokine (TARC)/CC ligand 17 (CCL17) as a diagnostic biomarker DILD. Patients methods: Between...
Background: In Japan, the number of patients with aggressive hematological malignancies (PHMs) admitted at palliative care unit (PCU) in their end-of-life (EOL) stage was fewer than that solid tumors due to several reasons. The assessment patient characteristics and methods survival prediction among PHMs EOL are warranted. Objectives: This study aimed identify current medical status method treated PCU. Setting/Subjects/Measurements: We retrospectively analyzed clinical data 25 our PCU...
This study describes the characteristic features of incidence hereditary red cell membrane disorders in Japanese population based on studies 1014 cases these from 605 kindred. Among them, there were 581 spherocytosis (HS) 303 kindred, 137 elliptocytosis (HE) 68 104 stomatocytosis (HSt) 64 and 34 protein 4.2 (P4.2) anomalies 20 41 lipid 27 In HS patients, eleven mutations band 3 (B3) gene, 15 ankyrin three which are pathognomonic for this disorder, identified. Most had not been reported and,...
A 66-year-old man was implanted with a pacemaker. Seven years after implantation he admitted due to cardiogenic cerebral embolism and warfarin therapy introduced. After that, suffered recurrent pericardial effusion for unexplained reasons. An exploratory thoracotomy revealed that the screw of atrial lead had penetrated through right auricular appendage wall.
Calreticulin (CALR) and JAK2-V617F gene mutations, which are major genetic mutations in patients with primary myelofibrosis (PMF) essential thrombocythemia (ET), exert different effects on the clinical features outcomes of these diseases. We analyzed 88 9 ET PMF, respectively, determined differences characteristics compared CALR mutations. The frequency were 64 22 %, respectively. Patients younger, had a lower white blood cell count, rate thrombotic events than JAK2 mutation. neutrophil...
A 26-year-old man with right lower mandibular and chest pain, fever, respiratory distress was urgently transported to our hospital. CT images revealed gas collection an abscess from the neck mediastinum bilateral pleural effusion. Descending necrotizing mediastinitis (DNM) induced by odontogenic infection of a molar diagnosed. The cervical mediastinal areas were drained, extensive debridement performed, necrotic tissue excised, broad-spectrum antibiotics administered immediately. Prompt...
Abstract This study is the first to report a familial case involving differing clinical courses of aplastic crisis triggered by parvovirus B 19 in two patients with HS , although similar eosin‐5‐maleimide‐binding test and sodium dodecylsulfate–polyacrylamide gel electrophoresis results had been obtained for both. One patient short‐term mild symptoms, whereas other developed severe anemia that required blood transfusion, experienced fever 13 days, did not have any rash. The severity reported...