A5101432521- Force Microscopy Techniques and Applications
- Nanopore and Nanochannel Transport Studies
- Protein Structure and Dynamics
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Silicone and Siloxane Chemistry
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Synthesis and properties of polymers
- Thermal properties of materials
- Influenza Virus Research Studies
- interferon and immune responses
- Advanced Chemical Sensor Technologies
- Digital Holography and Microscopy
- Lymphatic System and Diseases
- Adhesion, Friction, and Surface Interactions
- Conducting polymers and applications
- Orbital Angular Momentum in Optics
- Advanced Optical Imaging Technologies
- Blood properties and coagulation
- Crystallography and molecular interactions
- Material Dynamics and Properties
- Microfluidic and Bio-sensing Technologies
- Transport Systems and Technology
- Dermatologic Treatments and Research
Middle Tennessee State University
2023-2024
University of Shanghai for Science and Technology
2024
Zhejiang University of Science and Technology
2019-2023
Changchun Institute of Optics, Fine Mechanics and Physics
2023
Chinese Academy of Sciences
2023
Zhejiang Gongshang University
2008-2017
Knowledge Integration (United Kingdom)
2012
Liaoning University
2010
Zhejiang University
2005-2006
Wenzhou University
2005
The effect of the electric field on conformational properties protein 1BBL was investigated by molecular dynamics simulations. Our simulation results clearly capture structural transitions sample from helix to turn or random coil conformation induced increasing strength field. During our analysis, we found that stability is weakened, and stretched as an unfolded structure when it exposed in a sufficiently high characteristic time jump occurs evolution curves root mean square deviation (RMSD)...
Nonstructural protein 1 (NS1) is a non-structural of avian influenza virus. It can interact with variety proteins the host cells, enhancing expression viral and changing growth metabolism thereby virus' pathogenicity virulence. To investigate whether there are more that NS1 during infection, T7-phage display system was used to screen human lung cell cDNA library for could NS1. One positive specific clone obtained identified as nucleolar coiled-body phosphoprotein 1(NOLC1). The interaction...
BACKGROUND: The clinical outcomes of bipolar radiofrequency (RF) lipolysis, a prevalent non-invasive fat reduction procedure, hinge on the delicate balance between effective lipolysis and patient safety, with skin overheating subsequent tissue damage as primary concerns. OBJECTIVE: This study aimed to investigate novel technique, safeguarding through an innovative PID temperature control algorithm. METHODS: Utilizing COMSOL Multiphysics simulation software, two-dimensional model was...
Four categories of globular proteins, including all-α, all-β, α + β, and α/β types, are simplified as the off-lattice HNP model involving secondary-structural information each protein. The propensity three types residues, i.e., H, N, P to form a secondary structure is investigated based on 146 protein samples. We find that residues easy α-helices, whereas H have higher tendency construct β-sheets. statistical analysis also indicates occurrence invariably than which independent category....
We use the pruned-enriched-Rosenbluth method and modified orientation-dependent monomer-monomer interaction model to study translocation of a proteinlike chain through finite channel. The mean-square radius gyration per bond ⟨S2⟩∕N shape factor ⟨δ*⟩ chains with different secondary structures transporting channel radii R=1, 2, 3, 4, 20 are investigated in translocation. average Helmholtz free energy A∕N mechanical force f also presented. remains unchanged when X0<0 X0>1,...
Influenza A Non-structural protein 1 (NS1A) RNA-Binding Domain (RBD) bound to a double-stranded RNA (dsRNA), which can inhibit the activation of antiviral pathway. The chemical compound binding sites at this pocket have abilities block NS1 dsRNA-dependent transfected beta interferon promoter construct. molecular docking program AUTODOCK was used for virtual screening about 200,000 compounds. Two more typical compounds were selected as starting point predicting modes. Further analysis shows...
The translocation of a polymer chain through crowded cylindrical channel is studied using the Langevin dynamics simulations. influences field strength <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>F</mml:mi></mml:mrow></mml:math>, length id="M2"><mml:mrow><mml:mi>N</mml:mi></mml:mrow></mml:math>, and crowding extent id="M3"><mml:mrow><mml:mi mathvariant="normal">ρ</mml:mi></mml:mrow></mml:math> on time are evaluated, respectively. Scaling relation...
We study the translocation of a protein-like chain through finite cylindrical channel using pruned-enriched Rosenbluth method (PERM) and modified orientation-dependent monomer-monomer interaction (ODI) model. Attractive channels (∊cp = −2.0, −1.0, −0.5), repulsive 0.5, 1.0, 2.0), neutral 0) are discussed. The results dimension energy show that Z0 1.0 is an important case to distinguish types channels. For strong attractive channel, more contacts form during process translocation. It also...
The character of forming long-range contacts affects the three-dimensional structure globular proteins deeply. As different ability to form between 20 types amino acids and 4 categories proteins, statistical properties are thoroughly discussed in this paper. Two parameters NC ND defined confine valid residues detail. relationship hydrophobicity scales residue percentage each acid is given present work linear functions shown our results. It concluded that scale by chemical derivatives...
The noterate is a tool for predicting home mortgage rates, it often skewed and has missing information. could be affected by incomplete or inaccurate data, thus leading to predictions. Financial organizations including companies banks need consider the risk of uncertainty carefully make more accurate prediction based on some suitable models. To deal with this situation, in paper we compared six computational statistical methods, ordinary least square model, maximum likelihood estimation,...
Data preprocessing is a fundamental stage in deep learning modeling and serves as the cornerstone of reliable data analytics. These models require significant amounts training to be effective, with small datasets often resulting overfitting poor performance on large datasets. One solution this problem parallelization modeling, which allows model fit more effectively, leading higher accuracy sets overall. In research, we developed novel approach that effectively deployed tools such MPI MPI4Py...
Holography utilizes the principles of wave interference and diffraction to record reconstruct images, which can highly restore three-dimensional features objects provide an immersive visual experience. Dennis Gabor proposed concept holography in 1947 was awarded Nobel Prize Physics 1971. has gradually developed into two major research directions: digital (DH) computer-generated (CGH). empowered development fields such as 6G communication, intelligent healthcare, commercial MR headsets. In...
Elastic behaviors of protein-like chains are investigated by Pruned–Enriched–Rosenbluth method and modified orientation-dependent monomer-monomer interactions model. The chain is pulled away from the attractive surface slowly with elastic force acting on it. Strong adsorption interaction no both considered. We calculate characteristic ratio shape factor in process elongation. conformation change well depicted. changes “rod" to “sphere" at beginning Then, “rod". In end, becomes a as leaves...