A5085611407- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Family Support in Illness
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- HER2/EGFR in Cancer Research
- Economic and Financial Impacts of Cancer
- Childhood Cancer Survivors' Quality of Life
- Genomic variations and chromosomal abnormalities
- Genetic factors in colorectal cancer
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Arrhythmias and Treatments
- Learning Styles and Cognitive Differences
- Glioma Diagnosis and Treatment
- Biomedical Text Mining and Ontologies
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
Western General Hospital
1996-2018
NHS Lothian
2015
University of Edinburgh
1991-2008
Edinburgh Cancer Research
2008
Brain Tumour Charity
1993
Medical University of South Carolina
1991-1992
Children's Hospital of The King's Daughters
1991-1992
Eastern Virginia Medical School
1991-1992
Edinburgh Royal Infirmary
1989-1991
Women referred to a familial breast cancer clinic completed questionnaires before and after counselling at annual follow-up assess their risk estimate psychological characteristics. The aims were determine whether those who attended the overestimated or highly anxious influenced estimates levels of distress. (n = 450) this more likely underestimate (39%) than overestimate (14%) risk. Mean trait anxiety scores higher general population data (t 4.9, n 1059, P < 0.001) but not significantly...
Dedicated clinics have been established for the early diagnosis and treatment of women at risk inherited breast cancer, but effects such interventions are currently unproven. This second report on prospectively diagnosed cancer from European collaborating centres supports previous conclusions adds information genetic heterogeneity effect oophorectomy. Of 249 patients, 20% had carcinoma in situ (CIS), 54% infiltrating without spread (CaN0) 26% with (CaN+). Five-year survival was 100% CIS, 94%...
Abstract Women with a family history of breast cancer are commonly offered regular clinical or mammographic surveillance from age 30. Data on the efficacy such programmes limited. Clinical, pathological and outcome data were recorded all ovarian cancers diagnosed within familial at collaborating centers in Norway UK up to end 2005. These have been analyzed according mutation status affected women ( BRCA1 +ve, BRCA2 +ve mutation‐negative). Breast was 442 patients subsequently followed for...
<h3>Background:</h3> Increasingly women at high risk of breast cancer are opting for reducing surgery. The aim this study was to assess the effectiveness approach in both carriers and non-carriers <i>BRCA1/2</i>. <h3>Methods:</h3> Data from 10 European centres that offer a genetic counselling screening service were obtained prospectively 1995. Breast risks estimated life tables control group who did not undergo <h3>Results:</h3> combined have data on 550 undergone mastectomy with greater...
There is a need to integrate primary- and secondary-care cancer genetic services, but the most appropriate model of service delivery remains unclear. This study reports patients' expectations breast services comparison their satisfaction with two models. In first model, risk assessment was carried out using mailed family history data. Women estimated as being at high/moderate were offered an appointment familial clinic, those low sent letter reassurance. second all women seen by nurse...
This study compared the psychological impact of two models breast cancer genetics services in South East Scotland. One hundred and seventy general practices were randomised to refer patients existing standard regional service or novel community-based service. Participants completed postal questionnaires at baseline (n=373), 4 weeks (n=276) 6 months (n=263) assess perceived risk cancer, subjective objective understanding screening issues, distress, worry health behaviours. For participants...
Factors affecting completeness of excision and outcome, whether conservation or mastectomy, in 152 patients with localized impalpable breast cancer undergoing therapeutic needle-guided wide local were assessed by univariate multivariate analyses using multiple logistic regression. Independent factors related to at the first operation operator experience (P = 0.0001), size lesion 0.005). outcome 0.0003), more experienced operators having a higher rate conservation, tumour larger lesions being...
As part of a cluster randomised trial to assess an alternative model cancer genetics services, we gathered data on all referrals from general practitioners (GPs) services in South East Scotland over 4-year period. The referral rate per 1000 patients rose by 48% 0.21 the 2-year period before 0.31 during trial. This increase was much greater group offered GP clinic service (64% compared 38% those referred regional service). Thus, offer more local appeared have marked effect management these...
BACKGROUND: Surveillance programmes for women at increased genetic risk of breast cancer are being established worldwide but little is known their efficacy in early detection cancers and hence reduction mortality. METHODS: Data were contributed from seven centres participating the EU Demonstration Programme on Clinical Services Familial Breast Cancer. All tumours (n = 161) detected prospectively, time enrolment a screening programme, recorded. Analysis took account age diagnosis, whether...
Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a counselling and screening service show different approaches the option preventive surgery, although most adhere protocol including least two sessions psychological assessment. Thus far combined have data on 174 who undergone mastectomy with in excess 400 years follow up. Operations were carried out lifetime risks 25–80%, an average annual...
This study aimed to compare the impact of two versions a psychoeducational written intervention on cancer worry and objective knowledge breast risk-related topics in women who had been living with an increased risk familial for several years. Participants were randomised three conditions: scientific psychosocial information pack (Group 1), only 2) or standard care control 3). They completed postal questionnaires at baseline (n=163) 4 weeks (n=151). As predicted, there was significant...
Comparisons of outcomes health care in different systems can be used to inform policy. The EuroHOPE (European Healthcare Outcomes, Performance and Efficiency) project investigated the feasibility comparing routine data on selected conditions including breast cancer across participating European countries.Routine incidence, treatment mortality by age clinical characteristics for women over 24 years were obtained (for a calendar year) from linked hospital discharge records, death registers...
To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed referred to Scottish breast clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Cancer Registry was then interrogated determine subsequent age-specific incidence this cohort corresponding population figures. Among 2074 women, with an average follow-up 4.0 years, 28 invasive cancers...
Objective A high proportion of children and adolescents who have "difficult" or therapy-resistant asthma, are found to poor adherence maintenance therapies. Such individuals thus difficult asthmatics (for reasons adherence) rather than being young people with true asthma. In our centers, once daily ICS/ULABA (Relvar™) is considered if there an increase in reported interval symptoms, asthma attacks requiring hospital attendance rescue oral prednisolone, persistently low lung function despite...