A5102862832- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Lipoproteins and Cardiovascular Health
- Polyamine Metabolism and Applications
- Healthcare Quality and Management
- Gallbladder and Bile Duct Disorders
- Muscle and Compartmental Disorders
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Drug Transport and Resistance Mechanisms
- Diabetes Management and Research
- Bone health and treatments
- Blood donation and transfusion practices
- Bee Products Chemical Analysis
- Hepatitis Viruses Studies and Epidemiology
- Insect Utilization and Effects
- Diverticular Disease and Complications
AbbVie (United States)
2015-2024
University of Iowa
2015-2017
Rush University Medical Center
2014-2015
John Brown University
2014
University of Cincinnati
1996-2014
Harvard University Press
2012
Yale University
2009
Medical University of Vienna
2006
Amsterdam UMC Location University of Amsterdam
1990
University of Amsterdam
1990
Background & AimsAlthough hepatitis C virus (HCV) infection is common in patients with end-stage renal disease, highly efficacious, well-tolerated, direct-acting antiviral regimens have not been extensively studied this population. We investigated the safety and efficacy of ombitasvir co-formulated paritaprevir ritonavir, administered dasabuvir (with or without ribavirin) a prospective study stage 4 5 chronic kidney disease (CKD).MethodsWe performed single-arm, multicenter treatment-naïve...
Hepatitis B virus reactivation (HBVr) during and after immunosuppressive/immunomodulatory (IS/IM) therapy is associated with significant morbidity mortality, including hepatic decompensation acute liver failure. The risk of HBVr IS/IM has been heterogeneous often unpredictable. As a result, patients active or previous HBV infection are excluded from clinical drug trials such agents. Thorough screening for infection, antiviral prophylaxis, careful monitoring have proven to be effective in...
We analyzed phase 3 trial data of ombitasvir/paritaprevir/ritonavir and dasabuvir (3D) ± ribavirin (RBV) in genotype 1 chronic hepatitis C patients to investigate the impact 3D RBV on renal, cardiovascular metabolic extrahepatic manifestations (EHMs), including persistency 52 weeks post treatment differential by EHM disease severity.Estimated glomerular filtration rate (eGFR), fasting triglyceride glucose values from clinical trials were used assess EHMs, respectively. Two placebo-controlled...
The debriding potential of a recently discovered potent enzyme preparation derived from Antarctic krill (Euphausia superba) was compared to routine non-enzymatic treatment in 31 patients with venous leg ulcers. To assure reliable interpretation the cleaning effect, computer image analysis used measure wound size and amount debris day by day. Krill significantly (p less than 0.01) better treatment. necrotic area diminished 53%, while control group no reduction observed 7 days. median time...
IntroductionHepatitis C virus (HCV) infection is common in patients with end-stage renal disease. We investigated the safety and efficacy of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) ± dasabuvir (DSV) ribavirin (RBV) 2 phase 3, open-label, multicenter studies stage 4 or 5 chronic kidney disease (CKD).MethodsRUBY-I, Cohort enrolled treatment-naïve -experienced HCV genotype (GT) 1a 1b infection, without cirrhosis. Patients received 12 weeks (24 for GT1a cirrhosis) OBV/PTV/r + DSV; all...
Acute compartment syndrome is an orthopedic surgical emergency and may result in devastating complications the setting of delayed or missed diagnosis. Compartment has a variety causes, including posttraumatic postoperative swelling, external compression, burns, bleeding disorders, ischemia-reperfusion injury. Rare cases pediatric acute myeloid leukemia and, even less commonly, chronic have been reported. The authors report first known case patient without previously diagnosis leukemia. On...
Introduction: There is persistent shortage of cadaveric liver grafts for patients with end-stage disease. However, it not unusual pediatric (age 1-17) to be offered adult recipients which may declined secondary patient and recipient size miss-match. We looked at the outcomes using small transplantation in a single institution. Methods: A retrospective review was performed all transplant our medical center between 2002 -2012. Patients were included if they received full-size graft. who listed...
Department of Digestive Diseases Yale University School Medicine New Haven, CT The author declare no conflict interest. confirm that their is funding information to disclosure.