A5101711607- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Hemodynamic Monitoring and Therapy
- Advanced MRI Techniques and Applications
- Lung Cancer Research Studies
Hebei Medical University
2014-2025
Fourth Hospital of Hebei Medical University
2012-2025
Background: Radioresistance is the primary cause of treatment failure in esophageal squamous cell carcinoma, emphasizing importance identifying effective radiosensitizers. Objectives: This study aimed to explore effects and potential mechanisms Eg5 inhibitor K858 on radiosensitivity carcinoma TE-1 KYSE150 lines, as well xenografts (TE-1 cells). Methods: Cellular function was assessed using CCK8, wound healing, transwell invasion assays. Radiosensitivity parameters were derived from colony...
Abstract Background Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms radioresistance are still unclear. Irradiation (IR) stimulates changes tumor-derived exosome contents, which can be taken up by recipient cells, playing an important role proliferation, cycle apoptosis cells. This study investigated effect IR-induced exosomal high mobility group box 1 (HMGB1) on ESCC Methods Plasma exosomes were...
<b><i>Aim: </i></b>To explore the associations of diffusion-weighted magnetic resonance imaging (DWI) measurements with therapeutic effect (TE) on and survival esophageal carcinoma patients treated chemoradiotherapy (CRT). <b><i>Methods: </i></b>From March 2010 to December 2011, 77 were prospectively enrolled into a cohort study. DWI was performed at beginning 1-3 months after CRT. The immediate post-CRT TE evaluated according Response...
Abstract This retrospective study was conducted to evaluate the efficacy and safety of elective nodal irradiation (ENI) involved-field (IFI) for esophageal squamous cell carcinoma (ESCC) patients treated with intensity-modulated radiotherapy (IMRT). From January 2006 December 2012, 644 (ENI = 157, IFI 487) stage I IVa ESCC (AJCC 2010) at our institution were analyzed. Propensity score matching (PSM) used identify 471 314) well-balanced comparison. Overall survival (OS) primary outcome study....
To explore the effect of HMGB1 on radio-sensitivity esophageal cancer cells through regulating PI3K/Akt/ATM pathway.We observed expression and p-ATM in biopsies patients with immunohistochemical staining. Western blot RT-qPCR were applied to detect protein RNA related pathway, respectively. In addition, we inhibited PI3K/Akt pathway ly294002 activated it IGF1, then explored invasion, proliferation ability, apoptosis vitro by transwell, CCK8 assay, flow cytometry vivo, xenograft tumor model...
To explore the effects of FAM83D on proliferation, invasion and radiosensitivity human esophageal cancer cells to elucidate mechanism involved in regulation growth metastasis cells. This study included sixty-nine patients with cancer. The expression levels tissues paracarcinoma were measured. We also examined five cell lines. analyzed via MTS, Transwell, colony formation assays. effect knockdown apoptosis was assayed by flow cytometry. In addition, we changes metastasis-related molecules at...
This study was designed to investigate the efficacy and prognostic factors for immune checkpoint inhibitors (ICIs) combined with or without radio(chemo)therapy evaluate their toxicity in patients locally advanced recurrent/metastatic esophageal squamous cell carcinoma (LA/RM ESCC).In this study, 198 (LA/RM) ESCC who received ICIs radiotherapy/chemotherapy Department of Radiotherapy Fourth Hospital Hebei Medical University were retrospectively analyzed. Univariate multivariate analyses...
To investigate the predictive value of low dose volume lung on acute radiation pneumonitis (RP) in patients with esophageal cancer treated three-dimensional conformal radiotherapy (3D-CRT) only, and to analyze relation comprehensive parameters dose-volume V5, V20 mean (MLD) RP.Two hundred twenty-two by 3D-CRT have been followed up. The V5-V30 MLD were calculated from histogram system. clinical factors treatment collected analyzed. RP was evaluated according RTOG toxicity criteria.The grade...
To explore whether there is a relationship between gross tumor volume (GTV) and pathologic lymph node metastasis or prognosis of esophageal carcinoma, to provide new reference for carcinoma (EC).Six hundred seven patients received radical resection thoracic from May 2002 June 2006 in our hospital, their pre-operative CT images were transmitted the three-dimensional conformal radiotherapy planning system by network digital format. Esophageal GTV targets outlined volumes calculated. analyze...
Objective To investigate the accuracy of measurement lesion length by computed tomography(CT)scan and diffusion-weighted imaging(DWI)for esophageal carcinoma, to provide an optimized imaging method as a reference for target delineation in carcinoma. Methods Thirty-five patients with thoracic carcinoma from 2012 2013 were prospectively enrolled subjects. All underwent examinations endoscopy, CT scan thorax abdomen, DWI before radical surgery. Lesion lengths measured above methods...
To examine the survival benefit of definitive concurrent chemoradiotherapy (CCRT) compared to radiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) using a real-world patient population.This retrospective study included 2,762 ESCC across ten medical centers China from 2001 2017. A total 1,133 received and 815 were treated CCRT. The rates assessed by propensity-score matching (PSM) subgroup analysis.The baseline characteristics significantly different between two...
Background: Chemotherapy (CT) in combination with thoracic radiotherapy (RT) can improve the survival of patients limited-stage small cell lung cancer (LSSCLC). In current study, we evaluated prognostic factors, especially effect therapy integration and timing RT, on survival. Patients Methods: We retrospectively studied 142 LS-SCLC. All received RT 126 at least 2 cycles CT; 38 following CT cycles, 32 between 56 concurrently CT. Results: For all patients, 1-, 3-, 4-year overall (OS) rates...
To explore factors affecting the survival in patients after radical resection of esophageal carcinoma, and to provide a valuable reference for selecting treatment protocol surgery.Clinicopathological data 618 cancer who underwent at Fourth Hospital Hebei Medical University from May 2002 June 2006 were collected reviewed this study. All had no history, did not receive preoperative radiotherapy or chemotherapy, Karnofsky performance scores ≥ 70. Univariate analysis was performed by using...
The surrogacy of progression-free survival (PFS) for overall (OS) in esophageal squamous cell carcinoma (ESCC) remains unelucidated. This study aimed to determine the validity PFS as a surrogate endpoint OS ESCC patients treated with definitive radiotherapy or chemoradiotherapy (dRT/dCRT), well characterize prognostic factors and such patients.A total 3662 from 10 cancer centers were enrolled. One-, 2-, 3-year (PFS12, PFS24, PSF36, respectively) used time points analysis. At each point,...
Objective To explore the prognosis and related factors in T4 esophageal carcinoma with three-dimensional conformal radiotherapy(3D-CRT).Methods One hundred thirty patients cancer were treated 3D-CRT total irradiation dose of 50~76 Gy.Gender,age,location primary tumor,the different bite,the lesion length barium esophagogram,the largest diameter CT scanning image,metastasis lymph node,M stage,dose irradiation,chemotherapy recent efficacy used as analysis for Cox regression univariate...
Objective To investigate the failure mode in patients with stage pT3N0M0 thoracic esophageal squamous cell carcinoma (TESCC) after surgery, and to discuss significance feasibility of postoperative radiotherapy according mode. Methods A retrospective analysis was performed on 227 TESCC who met inclusion criteria from January 2007 December 2010. Their analyzed, and, reference relevant research, its target were explored. The Kaplan-Meier method used calculate overall survival (OS), local...
To investigate the influence of PI3K/AKT signaling pathway on proportion and characteristics stem-like CD90(+) subpopulation human hepatocellular carcinoma (HCC) cell line MHCC-97.MHCC-97H cultures were treated with inhibitor LY294002. The was determined by flow cytometry, expression related proteins measured Western blot. clonogenicity CD90(-) cells plate colony formation assay. tumorigenicity compared between subpopulations (with different concentrations) in xenograft experiments nude...