A5101781568- Urban Green Space and Health
- Land Use and Ecosystem Services
- Ubiquitin and proteasome pathways
- Cardiac pacing and defibrillation studies
- Urban Heat Island Mitigation
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Quantum Information and Cryptography
- Pharmaceutical and Antibiotic Environmental Impacts
- Autophagy in Disease and Therapy
- Quantum Mechanics and Applications
- DNA Repair Mechanisms
- Reproductive Biology and Fertility
- Alzheimer's disease research and treatments
- Diverse Aspects of Tourism Research
- Mitochondrial Function and Pathology
- Vehicle emissions and performance
- Sharing Economy and Platforms
- Sperm and Testicular Function
- Endoplasmic Reticulum Stress and Disease
- Atrial Fibrillation Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- Cardiac Arrhythmias and Treatments
Zhejiang University
2014-2024
Sir Run Run Shaw Hospital
2014-2024
Shanghai Electric (China)
2023
Second Affiliated Hospital of Zhejiang University
2022
South China Agricultural University
2020
South China Botanical Garden
2020
Zunyi Medical University
2019
Abstract Protein neddylation is catalyzed by a activating enzyme (NAE, E1), an E2 conjugating enzyme, and E3 ligase. In various types of human cancers, the pathway abnormally activated. Our previous study validated that UBE2F promising therapeutic target in lung cancer. Although NAE inhibitor MLN4924/pevonedistat currently under clinical investigation as anti-cancer agent, there are no small molecules available selectively UBE2F. Here, we report, for first time, discovery, via...
Abstract MLN4924 is a first-in-class small molecule inhibitor of NEDD8-activating enzyme (NAE), which currently in several clinical trials for anti-cancer applications. However, also showed some off-target effects with potential to promote the growth cancer cells counteracts its anticancer activity. In this study, we found that increases levels PD-L1 mRNA and protein dose- time-dependent manners. Mechanistic study effect largely independent neddylation inactivation, but due activation both...
Protein neddylation is catalyzed by a three-enzyme cascade, namely an E1 NEDD8-activating enzyme (NAE), one of two E2 NEDD8 conjugation enzymes and several E3 ligases. The physiological substrates are the family members cullin, scaffold component cullin RING ligases (CRLs). Currently, potent inhibitor, MLN4924, also known as pevonedistat, in clinical trials for anti-cancer therapy. Here we report discovery, through virtual screening structural modifications, small molecule compound HA-1141...
His bundle pacing (HBP) and left branch (LBBP) both provide physiologic which maintain ventricular synchrony. They improve heart failure (HF) symptoms in atrial fibrillation (AF) patients. We aimed to assess the intra-patient comparison of function remodeling as well leads parameters corresponding two modalities AF patients referred for intermediate term.Uncontrolled tachycardia with implantation successfully were randomized either modality. Echocardiographic measurements, New York Heart...
In the limit of weak coupling between a system and its reservoir, we derive time-convolutionless (TCL) non-Markovian master equation for two-level interacting with zero-temperature structured environment no rotating wave approximation (NRWA). By comparing dynamics RWA, demonstrate impact RWA on dynamics, as well effects non-Markovianity preservation atomic coherence, squeezing, entanglement.
ABSTRACT Coridius chinensis ( C. ) is a traditional Chinese medicine that has been used to treat pain, erectile dysfunction, and other diseases. Our previous study demonstrated manganese‐induced reproductive damage was partially rescued by medium dose of treatment in rat. However, the underlying mechanism unknown. In this study, we found weight organs sperm count manganese‐exposed rat were extracts (CcE) treatment. The number apoptotic cells significantly decreased expression...
Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies Alzheimer disease (AD) patients and mouse models. However, for presymptom diagnosis of AD are still under investigation, the molecular changes pathogenesis.In this study, we aim to analyzed early APPSw,Ind mice conduct further functional on interesting proteins.We used isobaric tags relative absolute quantitation (iTRAQ) approach combined with mass spectrometry examine...
Urban recreationists interact at various locations times, resulting in potential conflicts. For sustainable urban tourism, this study extends the resident–tourist comparison into that of local, domestic, and overseas tourists applies social network analysis to compare spatiotemporal patterns these three types tourists. Results show locals are accustomed visiting natural parks hutongs on weekends, while out-of-town might tour popular sites city center during holidays, where domestic may still...
Left bundle branch pacing (LBBP) is an emerging physiological technique that expanded in recent reports. The long-term safety and feasibility of LBBP lack adequate evaluation.The study aimed to evaluate the lead performance clinical outcomes LBBP.We retrospectively enrolled 123 consecutive patients scheduled for implantation from January December 2018. parameters, electrocardiograms, echocardiographic measurements, complications associated with were tracked at implant follow-up.LBBP was...
Transcatheter arterial chemoembolization (TACE) has been widely applied in palliative treatment of unresectable primary and metastatic liver cancer,and its efficiency safety also have acknowledged.However,there is a wide range related complications,such as upper gastrointestinal hemorrhage,liver failure,pulmonary embolism,embolic cholecystitis so on.As serious complication TACE,bile duct injury reported intermittently since the introduction hepatic embolization therapy.However,the exact...
Aiming at the problems of large carbon emission detection error and low footprint measurement accuracy power supply chain, a reliable system chain based on LCA is designed. The existing blockchain artificial intelligence algorithm improved by integrating different scale dimension characteristics, which improves analysis calculation ability chain. Life Cycle Assessment (LCA) used for standard control abnormal data. Blockchain technology introduced to build network, collection data realized....
Abstract Background Chlortetracycline is widely used for disease treatment and prevention in animal production system. However, the impact of chlortetracycline on gastrointestinal tract microbial communities growing chickens has not been fully explored. Results Chickens received 5-day-course at actual therapeutic dose/low doses. By using 16S-rRNA sequencing-based approach, We found predominant Firmicutes Oscillospira significantly increased, while Shigella decreased therapeutic-dose group....