A5008295165- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Evolutionary Psychology and Human Behavior
- Herpesvirus Infections and Treatments
- Brain Tumor Detection and Classification
- Neurogenesis and neuroplasticity mechanisms
- Identification and Quantification in Food
- Primate Behavior and Ecology
- Virus-based gene therapy research
- Evolutionary Game Theory and Cooperation
- Single-cell and spatial transcriptomics
- Metabolism and Genetic Disorders
- Viral gastroenteritis research and epidemiology
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Electron Spin Resonance Studies
- Atomic and Subatomic Physics Research
University of Pittsburgh
2020-2025
National Institute of Neurological Disorders and Stroke
2019-2021
National Institutes of Health
2019-2021
Universidade Federal do Rio de Janeiro
2012-2020
Institute of Biochemistry
2018
Ministry of Science, Technology and Innovation
2018
Alzheimer’s disease is the commonest cause of dementia in elderly, but its pathological determinants are still debated. Amyloid-β plaques and neurofibrillary tangles have been implicated either directly as disruptors neural function, or indirectly by precipitating neuronal death thus causing a reduction number. Alternatively, initial cognitive decline has attributed to subtle intracellular events caused amyloid-β oligomers, resulting after massive synaptic dysfunction followed degeneration...
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal (PPC), and cingulate (PCC). Neuroimaging studies have shown that also exists in non-human primates, suggesting it may be conserved feature primate brain. Here, we found that, common marmosets, dorsolateral (dlPFC; peak at A8aD) has robust fMRI reciprocal anatomical...
The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each type has distinct roles for the functional operation circuits, and ultimately, brain physiology in general. Since absolute number considered proxy its complexity, approach to better understand how works unravel cellularity quantitative relations between populations; other words, population cells quantitatively structured, relation another. Oligodendrocytes are...
The standard anatomical brain template provides a common space and coordinate system for visualizing analyzing neuroimaging data from large cohorts of subjects. Previous templates atlases the marmoset were either based on single individual or lacked essential functionalities analysis. Here, we present new population-based in-vivo tools derived multi-modal 27 marmosets, including multiple types T1w T2w contrast images, DTI contrasts, field-of-view MRI CT images. We performed multi-atlas...
The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress still needed in understanding the functional and structural organization of brain to rival that documented longstanding preclinical model species, like mice, rats, Old World primates. To accelerate such progress, we present Marmoset Functional Brain Connectivity Resource (marmosetbrainconnectome.org), currently consisting over 70 h resting-state fMRI...
Abstract Comprehensive integration of structural and functional connectivity data is required to model brain functions accurately. While resources for studying the non-human primate brains already exist, their with has remained unavailable. Here we present a comprehensive resource that integrates most extensive awake marmoset resting-state fMRI available date (39 monkeys, 710 runs, 12117 mins) previously published cellular-level neuronal tracing (52 143 injections) multi-resolution diffusion...
We present a new clustering-enabled regression approach to investigate how functional connectivity (FC) of the entire brain changes from childhood old age. By applying this method resting-state magnetic resonance imaging data aggregated three Human Connectome Project studies, we cluster regions that undergo identical age-related in FC and reveal diverse patterns these for different region clusters. While most connections between pairs show minimal yet statistically significant with age, only...
Abstract The corpus callosum (CC) is the largest white matter structure and primary pathway for interhemispheric brain communication. Investigating callosal connectivity crucial to unraveling brain’s anatomical functional organization in health disease. Classical studies have characterized bulk of axonal fibers as connecting primarily homotopic cortical areas. Whenever detected, heterotopic were ascribed altered sprouting pruning mechanisms neurodevelopmental diseases such CC dysgenesis...
We establish a reliable method for selectively delivering adeno-associated viral vectors (AAVs) across the blood-brain barrier (BBB) in marmoset without need neurosurgical injection. focally perturbed BBB (∼1 × 2 mm) area 8aD of frontal cortex four adult monkeys using low-intensity transcranial focused ultrasound aided by microbubbles. Within an hour opening BBB, either AAV2 or AAV9 was delivered systemically via tail-vein In all marmosets, fluorescence-encoded neurons were observed at site...
Abstract The use of the common marmoset (Callithrix jacchus) for neuroscientific inquiry has grown precipitously over past two decades. Despite windfalls grant support from funding initiatives in North America, Europe, and Asia to model human brain diseases marmoset, marmoset-specific apparatus are sparse availability commercial vendors thus often developed reside within individual laboratories. Through our collective research efforts, we have designed vetted myriad designs awake or...
The corpus callosum (CC), the anterior (AC), and posterior (PC) commissures are principal axonal fiber bundle pathways that allow bidirectional communication between brain hemispheres. Here, we used Allen mouse connectivity atlas high-resolution diffusion-weighted MRI (DWI) to investigate interhemispheric bundles in C57bl6/J mice, most commonly wild-type model biomedical research. We identified 1) commissural projections from primary motor area through AC contralateral hemisphere; 2)...
Abstract The evolution of mating strategies is not well understood. Several hypotheses have been proposed to explain the variation in strategies, with varying levels support. Specifically, female dispersion, adult sex ratio and mate guarding as drivers monogamous strategies. In this study, we used an agent-based model (ABM) examine how different behaviors evolve a population under conditions related these putative drivers, looking understand interaction between them. We found among factors...
Developmental malformations (dysgenesis) of the corpus callosum lead to neurological conditions with a broad range clinical presentations. Investigating altered brain connectivity patterns is crucial understanding both adaptive and maladaptive neuroplasticity in dysgenesis patients. Here, we acquired structural diffusion-weighted resting-state functional MRI data from cohort 11 patients (five agenesis six hypoplasia) compared their healthy subjects selected Human Connectome Project. We found...
Corpus callosum dysgenesis (CCD) is a developmental brain condition in which some white matter fibers fail to find their natural course across the midplane, reorganizing instead form new aberrant pathways. This type of reorganization known as long-distance plasticity (LDP). The present work aimed characterize Balb/c mouse strain model CCD. We employed high-resolution anatomical MRI 81 and 27 C57bl6 mice show that presents variance size CC 3.9 times higher than normotypical C57bl6. also...
Cortical lesions are a primary driver of disability in multiple sclerosis (MS). However, noninvasive detection cortical with vivo magnetic resonance imaging (MRI) remains challenging. Experimental autoimmune encephalomyelitis (EAE) the common marmoset is relevant animal model MS for investigating pathophysiological mechanisms leading to brain damage. This study aimed characterize marmosets EAE using ultrahigh-field (7 T) MRI and histological analysis. Tissue preparation was optimized enable...
The corpus callosum (CC), the largest brain commissure and primary white matter pathway for interhemispheric cortical connectivity, was traditionally viewed as a predominantly homotopic structure, connecting mirror areas of cortex. However, new studies verified that most callosal commissural fibers are heterotopic. Recently, we reported ~75% connections in brains mice, marmosets, humans heterotopic, having an essential role determining global properties networks. In present study, leveraged...
Abstract Cortical neurons of eutherian mammals project to the contralateral hemisphere, crossing midline primarily via corpus callosum and anterior, posterior, hippocampal commissures. We recently reported named thalamic commissures (TCs) as an additional interhemispheric axonal fiber pathway connecting cortex thalamus in rodent brain. Here, we demonstrate that TCs also exist primates characterize connectivity these pathways with high-resolution diffusion-weighted MRI, viral tracing, fMRI....
The corpus callosum, the principal structural avenue for interhemispheric neuronal communication, controls brain’s lateralization. Developmental malformations of callosum (CCD) can lead to learning and intellectual disabilities. Currently, there is no clear explanation these symptoms. Here, we used resting-state functional MRI (rsfMRI) evaluate dynamic connectivity (rsFC) in both cingulate cortex (CG) sensory areas (S1, S2, A1) three marmosets ( Callithrix jacchus ) with spontaneous CCD. We...
The present work describes the design characterization and tests of a 14-channel receive-only array for marmoset brain MRI at 9.4T. coil was designed to maximize SNR over entire head common marmoset, considering anesthesia apparatus, such as ear bars mask.