A5101699998- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Sparse and Compressive Sensing Techniques
- Medical Imaging Techniques and Applications
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Histone Deacetylase Inhibitors Research
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Cardiac tumors and thrombi
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- Radar Systems and Signal Processing
- Chronic Lymphocytic Leukemia Research
- Lipoproteins and Cardiovascular Health
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
First Affiliated Hospital of Xiamen University
2008-2025
Xiamen University
2022-2025
Liuzhou General Hospital
2021-2024
Tongji University
2023
Fourth Affiliated Hospital of Guangxi Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Fujian Medical University
2008-2021
Guangxi University of Science and Technology
2018
Shenzhen University
2016
Abstract Purpose: Fibroblast activation protein (FAP) is a promising target for tumor treatment. In this study, we aimed to investigate the safety and efficacy of albumin binder-conjugated FAP-targeted radiopharmaceutical, 177Lu-EB-FAPI (177Lu-LNC1004), in patients with metastatic radioiodine-refractory thyroid cancer (mRAIR-TC). Patients Methods: This open-label, non-randomized, first-in-human, dose-escalation, investigator-initiated trial had 3+3 design involved 6-week 177Lu-LNC1004...
This study focused on the development and evaluation of four [68Ga]-labeled cyclic TMTP1 peptide-based probes for targeting highly metastatic hepatocellular carcinoma (HCC). The probes─[68Ga]Ga-N-G-NVvRQ, [68Ga]Ga-c[K(N)NVvRQ], [68Ga]Ga-c[K(N)NVVRQ], [68Ga]Ga-c[K(N)NVvRQ]2─were designed using a head-to-tail cyclization strategy to enhance their stability, improve tumor targeting, reduce uptake in nontarget organs. microPET imaging results showed that although all was similar at each time...
Recognizing the significance of SPECT in nuclear medicine and pivotal role fibroblast activation protein (FAP) cancer diagnosis therapy, this study focuses on development 99mTc-labeled dimeric HF2 with high tumor uptake image contrast. The was synthesized radiolabeled 99mTc one pot using various coligands (tricine, TPPTS, EDDA, TPPMS) to yield [99mTc]Tc-TPPTS-HF2, [99mTc]Tc-EDDA-HF2, [99mTc]Tc-TPPMS-HF2 dimers. imaging results indicated that [99mTc]Tc-TPPTS-HF2 exhibited higher...
Abstract Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy safety of 177Lu-Evans blue–FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) treating end-stage metastatic tumors. Patients Methods: single-arm, single-center, phase II trial included 28 patients with progressive malignancies (11 types) high FAP expression...
Efforts have been devoted to select eligible candidates for PD-1/PD-L1 immune checkpoint blocker (ICB) immunotherapy. Here, we a serendipitous finding of positron emission tomography (PET) imaging tracer 2-[18F]FDG as potential immunomodulator. Therefore, hypothesize that could induce PD-L1 expression change and create an immune-favorable microenvironment tumor immunotherapy.We designed series assays verify upregulation, tested immunotherapy regimens based on anti-PD-L1 mAb, monotherapy in...
Immune checkpoint blockers (ICBs) targeting programmed death receptor 1 (PD-1) ligand (PD-L1) for immunotherapy have radically reformed oncology. It is of great significance to enhance the response rate ICB in cancer patients. Here, a radioiodinated anti-PD-L1 antibody (131I-αPD-L1) was developed PD-L1-targeted single-photon emission computed tomography (SPECT) imaging and αPD-L1 immunotherapy. Flow cytometry immunofluorescence staining were performed identify PD-L1 upregulation time-...
TMTP1 (NVVRQ) has been proven to selectively target various highly metastatic tumor cells. Nonetheless, existing probes encounter challenges such as rapid blood clearance, limited uptake, and inadequate suitability for therapeutic interventions. To overcome these constraints, we designed synthesized eight peptide probes, employing innovative chemical modification strategies involving d-amino acid retro-inverso isomerization. Notably, [68Ga]TV2 exhibited particularly impressive performance,...
Peptide receptor radionuclide therapy (PRRT) with radiolabeled SSTR2 agonists is a treatment option that highly effective in controlling metastatic and progressive neuroendocrine tumors (NETs). Previous studies have shown an agonist combined albumin binding moiety Evans blue (denoted as 177Lu-EB-TATE) characterized by higher tumor uptake residence time preclinical models patients NETs. This study aimed to enhance the vivo stability, pharmacokinetics, pharmacodynamics of 177Lu-EB-TATE...
Abstract Intravascular brachytherapy requires advances in radio‐embolization technologies that combine brilliant radiostability efficacy with a facile and green synthesis route. A hybrid‐integrated radioactive microsphere strategy using phosphorylcholine‐modified lutetium‐177 coordinated polymeric microspheres ( 177 Lu‐PCMs) is reported are fabricated via radiation‐induced graft polymerization for imaging‐guided locoregional intravascular brachytherapy. The underlying formation mechanism of...
The aims of this study were to evaluate the diagnostic value adenosine thallium-201 myocardial perfusion imaging and compare it with exercise stress for detecting coronary artery disease (CAD) at an early stage. Forty-one patients suspected CAD randomly divided into two groups. In Group 1 (n=21) was undertaken; performed in 2 (n=20). Coronary angiography (CAG) each patient within weeks before or after single photon emission computed tomography (SPECT). Adenosine group vs. group, sensitivity...
Overexpression of estrogen receptors (ERs) is one the important characteristics most breast cancers. We aim to develop a new type ER-specific radioiodine-labeled derivative ([131I]IPBA-EE), which was modified with an albumin-specific ligand 4-(p-iodophenyl) butyric acid (IPBA) improve metabolic stability and enhance ER-targeting ability estrogen. [131I]IPBA-EE can effectively bind albumin in vitro, its dissociation constant (Kd = 0.31 μM) similar IPBA 0.30 μM). The uptake ER-positive MCF-7...
Abstract Radioactive microspheres have shown excellent therapeutic effects in the treatment of advanced hepatocellular carcinoma (HCC) due to indiscriminate embolization and killing tumor cells. However, limitations such as unstable loading, vivo reflux, untrackable radioactive restrict their clinical applicability. Herein, a novel injectable lutetium‐177‐labeled 3D hollow porous radio‐granular hydrogels with double‐cross‐linked network ( 177 Lu‐3D‐HPGH) are synthesized via microfluidics...
In this paper, a novel method based-on Doppler compressive sampling for the sparsity-based space-time adaptive processing (STAP) is proposed. our method, radar transmits small amount of pulses randomly extracted from aperiodic pulse sequence. Then, we build sparse model with sampling, analyze capability solving ambiguity, and generate angle-Doppler image both targets clutter range bin interest. Simulation results illustrate that phenomenon ambiguity disappear recovery performance proposed...
In this paper, we focus on sparsity-based space-time adaptive processing (STAP) in airborne radar with compressive sampling both Doppler and spatial domains. Compared the uniform pluses repetition Frequency (UPRF) arrays (UA) radar, designed transmits random pulse interval pulses receives returns arrays, which reduces number of one coherent (CPI) brings down sensors. Firstly, build sparse model spatial-temporal sampling, analyze restricted isometry property (RIP) for steering dictionary....
Purpose: Tumor Necrosis Factor Receptor 1 (TNFR1) and integrin αvβ3 receptor are overexpressed in breast cancer. We hypothesized that a peptide ligand recognizing both receptors single receptor-binding probe would be advantageous. Here, we developed novel 18 F-labeled fusion [ F]-NOTA-Gly3- E(2PEG4-RGD-WH701) targeting dual (TNFR1 αvβ3) evaluated the diagnostic efficacy of this radioactive MDA-MB-231 MCF-7 xenograft models mice. Methods: The NOTA-conjugated RGD-WH701 analog was radiolabeled...
Two novel PEGylated ethinylestradiol (PEG = poly(ethylene glycol)) estrogen receptor (ER) targeting probes [131I]EITE and [131I]MITE were synthesized evaluated. Both had a nanomolar binding affinity to the ER (36.47 nM for 61.83 [131I]MITE). They showed high uptake in ER-positive MCF-7 cells tumors, which could be significantly blocked by coinjection of excess estradiol. Their specificities further demonstrated low ER-negative MDA-MB-231 tumors. The maximum tumor-to-muscle (T/M) ratios reach...