A5053329201- Antimicrobial Resistance in Staphylococcus
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Epilepsy research and treatment
- Bacterial Identification and Susceptibility Testing
- Cultural Insights and Digital Impacts
- French Urban and Social Studies
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Lipid Membrane Structure and Behavior
- Intensive Care Unit Cognitive Disorders
- Synthesis and pharmacology of benzodiazepine derivatives
- Abdominal Surgery and Complications
- Plant tissue culture and regeneration
- COVID-19 and healthcare impacts
- Vibrio bacteria research studies
- Computational Drug Discovery Methods
- Antibiotic Use and Resistance
Université de Rennes
2025
Inserm
1994-2025
Centre Hospitalier Universitaire de Rennes
2020-2025
Hôpital Pontchaillou
2024
Bacterial RNAs & Medicine
2021-2023
Méditerranée Infection Foundation
2020
Institut de Médecine Tropicale du Service de Santé des Armées
2020
Aix-Marseille Université
2020
Institut de Recherche pour le Développement
2020
Hôpital d'Instruction des Armées Sainte-Anne
2012
Small regulatory RNAs (sRNAs) are key players in bacterial networks. Monitoring their expression inside living colonized or infected organisms is essential for identifying sRNA functions, but few studies have looked at during host infection with pathogens. Insufficient vivo monitoring attest to the difficulties collecting such data, we therefore developed a non-mammalian model using larval Galleria mellonella analyze roles of Staphylococcus aureus sRNAs and quickly determine possible...
Introduction Central venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence S. haemolyticus -associated CLABSIs French neonates is increasing, mechanisms underlying this trend remain unclear. Methods We examined microorganisms 108 line infusion sets used infants across 12 intensive units, and collected at time removal. Results varied widely type (28 types; 1-6 parts) length (10-180 cm, mean 52.9...
Background Staphylococcus haemolyticus (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown. Aim To investigate increase SH vascular catheter-related neonates describe the molecular epidemiology France between 2019 2023. Methods We analysed clinical microbiological surveillance data from French national network for central (venous umbilical)...
Abstract Background The aim of the present work was to assess i) ex vivo activity pyronaridine (PND) and piperaquine (PPQ), as new components artemisinin-based combination therapy (ACT), define susceptibility baseline, ii) their activities compared other partner drugs, namely monodesethylamodiaquine (MDAQ), lumefantrine (LMF), mefloquine (MQ), artesunate (AS) dihydroartemisinin (DHA) against 181 Plasmodium falciparum isolates from African countries, India Thailand, iii) in vitro...
Abstract Background The Plasmodium falciparum chloroquine transporter gene ( pfcrt ) is known to be involved in and amodiaquine resistance, more particularly the mutations on loci 72 76 localized within second exon. Additionally, new (T93S, H97Y, C101F, F145I, M343L, C350R G353V) were recently shown associated with vitro reduced susceptibility piperaquine Asian or South American P. strains. However, very few data are available prevalence of these their effect parasite anti-malarial drugs,...
Summary The effect of zopiclone (7.5 mg) on attention, vigilance and memory components was evaluated during a nocturnal period in comparison to placebo, zolpidem (10 flunitrazepam (1 double blind, randomized study, after administration single dose 16 young healthy volunteers. It appears that there is clear attention vigilance; this apparent the kinetic phase absorption medication. transient absent four hours ingestion drug. objective results are not strictly consistent with chronology...
Abstract To increase the knowledge about S. capitis in neonatal setting, we conducted a nationwide 3-month survey 38 intensive care units (NICUs) covering 56.6% of French NICU beds. We demonstrated 14.2% BSI ( S.cap BSI) among nosocomial BSIs. incidence rate was 0.59 per 1000 patient-days. A total 55.0% BSIs were late onset catheter-related The strains infected preterm babies (median gestational age 26 weeks, median birth weight 855 g). They resistant to methicillin and aminoglycosides...
Summary Background: Hypothermia potentiates neuromuscular blockade in adults during cardiopulmonary bypass (CPB) but the pediatric literature is sparse. Temperature‐dependent Hoffman degradation of cisatracurium may allow reduction infusion rate (IR) hypothermia. The effect hypothermic CPB on pharmacokinetics (PK) and pharmacodynamics (PD) has not been described children. Methods materials: Using monitoring with a Datex Relaxograph, IR was adjusted to obtain pseudo‐steady state each phase...
Introduction. Staphylococcus aureus is a skin and mucous commensal bacterium of warm-blooded animals. In humans, the nose main ecological niche S. , nasal carriage risk factor for developing an endogenous infection. colonization multifactorial process, involving inter-species interactions among microbiota. Aims. The objectives this study were to characterize microbiota carriers non-carriers demonstrate importance relationships in adhesion key step colonization. Methodology. First, we...
Abstract Background Plasmodium falciparum resistance to most antimalarial compounds has emerged in Southeast Asia and spread Africa. In this context, the development of new drugs is urgent. Objectives To determine baseline vitro activity methylene blue (Proveblue®) on African isolates whether parasites have different phenotypes susceptibility blue. Methods Ex vivo was measured for 609 P. patients hospitalized France malaria imported from A Bayesian statistical analysis designed describe...
Cet article se penche sur la pensée de l’art à l’œuvre chez Balzac partir d’un syntagme qu’on trouve quelques reprises le romancier vers les années 1840, et qui synthétise l’entreprise La Comédie humaine : « peindre société moderne en action ». Moins tributaire l’idée antique classique l’ ut pictura poesis , fait peinture, tant que duplication visible nature, modèle l’art, peinture balzacienne comprend plutôt autour notion tableau. Entre copie invention, tableau balzacien donne lire comme...
Pseudomonas aeruginosa is a well-recognized opportunistic pathogen frequently responsible for hospital-acquired infections. Acquisition routes of P are both endogenous and exogenous, including transmission from portion the hospital water system.