A5064827031- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Polyomavirus and related diseases
- Occupational and environmental lung diseases
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- AI in cancer detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatitis Pathology and Treatment
- Laser Material Processing Techniques
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Endoplasmic Reticulum Stress and Disease
- Full-Duplex Wireless Communications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Melanoma and MAPK Pathways
- Fibroblast Growth Factor Research
- RNA regulation and disease
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2017-2024
Azienda Ospedaliera Ospedale Maggiore
2023
Azienda Ospedaliero Universitaria Maggiore della Carita
2017-2022
Assistance Publique – Hôpitaux de Paris
2018
University of Pavia
2018
Sorbonne Université
2018
Allen Institute for Brain Science
2018
Institut du Cerveau
2018
Centre National de la Recherche Scientifique
2018
Inserm
2018
Abstract Pleomorphic xanthoastrocytoma (PXA) in its classic manifestation exhibits distinct morphological features and is assigned to CNS WHO grade 2 or 3. Distinction from glioblastoma variants lower glial glioneuronal tumors a common diagnostic challenge. We compared morphologically defined set of PXA (histPXA) with an independent set, by DNA methylation analysis (mcPXA). HistPXA encompassed 144 all subjected array analysis. Sixty-two histPXA matched the class mcPXA. These were combined...
To characterize the prevalence and prognostic significance of major driver molecular alterations in adult midline diffuse gliomas (MLG).Adults with histologically proven MLG diagnosed between 1996 2017 were identified from our tumor bank, systematically reviewed, reclassified according to WHO 2016. Targeted sequencing was performed, including determination H3F3A, HIST1H3B, TERTp, IDH1/2, FGFR1, p16/CDKN2A, EGFR status.A total 116 patients (M/F 71/45, median age 46.5 years) (17 cerebellar, 8...
Innovative approaches to improve diagnostic yield of endoscopic ultrasound-guided tissue acquisition (EUS-TA) have focused on needle design with development fine-needle biopsy (FNB) needles microcore-acquisition technology. Recently, a 20-gauge (20G) antegrade-cutting-side-bevelled (ProCore®) was developed for EUS-TA, but data about its performance and histological capability are scant.We assessed the histologic retrieval rate new 20G compared 22G reverse-side-bevelled EUS sampling solid...
Abstract Human cytomegalovirus (HCMV) is an opportunistic pathogen causing severe diseases in immunosuppressed individuals. To replicate its double-stranded DNA genome, HCMV induces profound changes cellular homeostasis that may resemble senescence. However, it remains to be determined whether HCMV-induced senescence contributes organ-specific pathogenesis. Here, we show a direct cytopathic effect of on primary renal proximal tubular epithelial cells (RPTECs), natural setting disease. We...
The American Society of Clinical Oncology/College Pathologists (ASCO/CAP) 2013 guidelines for HER2 assessment have increased the number equivocal breast carcinomas following in situ hybridization reflex testing, that is, "double equivocal" (equivocal protein expression and gene copy number). Forty-five double-equivocal were subjected to Prosigna analysis. Twenty-seven cases investigated genes found be differentially expressed between estrogen receptor (ER)-positive/HER2-positive (N=22)...
Lung cancer is still the leading cause of cancer-related death worldwide. Interest growing towards early detection and advances in liquid biopsy to isolate circulating tumor cells (CTCs). This pilot study aimed detect epithelial CTCs peripheral blood early-stage non-small cell lung (NSCLC) patients. We used Smart BioSurface® (SBS) slide, a nanoparticle-coated slide able immobilize viable nucleated cellular fraction without pre-selection preserve integrity. Forty patients undergoing resection...
// Consalvo Petti 1 , Gabriele Picco 1,2 Maria Luisa Martelli Elena Trisolini 2,3 Enrico Bucci 4 Timothy Perera 5 Claudio Isella and Enzo Medico Candiolo Cancer Institute - FPO IRCCS, Italy 2 Department of Oncology, University Torino, 3 Istituto Nazionale Biostrutture e Biosistemi, Roma, Biodigitalvalley Srl, Pont Saint Martin, Aosta, Janssen Research Development, Oncology Discovery, Beerse, Belgium Correspondence: Medico, email: Keywords : drug resistance; RAF1; BRAF; MET; gastric cancer...
Aims High mobility group box 1 ( HMGB 1) is a chromatin structural protein, expressed ubiquitously in the nuclei of mammalian cells. When transported extracellularly, it acts as tumour suppressor and oncogenic protein. In malignant pleural mesothelioma MPM ), high serum levels have been related to poor prognosis. Conversely, significance expression tissues still unclear. Methods results Biopsy samples from 170 patients with were assessed by immunohistochemistry reverse...
Many malignancies that occur in high excess kidney transplant recipients (KTRs) are due to viruses thrive the setting of immunosuppression. Keratinocyte carcinoma (KC), most frequently occurring cancer type KTR, has been associated with skin infection by human papillomavirus (HPV) from beta genus. In this report, we extend our previous investigation aimed at identifying presence active β-HPV tumors KTRs through detection viral protein expression. Using a combination antibodies raised against...
Merkel cell polyomavirus (MCPyV) has been identified in samples of carcinoma (MCC), an aggressive skin cancer. Seroepidemiologic studies indicated a high frequency MCPyV infection humans, suggesting respiratory and faecal–oral routes, or transmission by contact. Since MCC is more frequent immunocompromised patients, reactivation latently infecting target cells proposed. However, neither definite ways nor specific organs have with certainty. Ten autopsies extensive organ sampling for total...
2005 Background: to characterize clinical, molecular and radiological features of diffuse gliomas with FGFR3-TACC3 fusions or FGFR1 mutations, which are both actionable new oral anti-FGFR inhibitors. Methods: We screened for 1112 (861 grade IV, 140 III 111 II) by RT-PCR. performed sequencing hotspot mutations (N546 K656) in 73 midline (8 II, 10 III, 54 affecting cerebellum, spinal cord, brainstem, thalamus diencephalon) 479 hemispheric (170 151 157 II). Results: identified 50 (all IDH...
Abstract BACKGROUND AND RATIONALE: Immunohistochemistry (IHC) and in situ hybridization (ISH) represent the cornerstone of HER2 evaluation breast cancer (BC). We have demonstrated that up to 13% BCs with equivocal expression (score 2+ IHC) harbor an gene status (HER2/CEP17 <2 mean copy number between 4 6), leading definition double-equivocal category. When we assessed levels these cases by a PCR-based method observed gain 25%. tested protein quantitative assay, ranged from those score...
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules regulating mRNAs translation. Significant differences in miRNAs expression have been found glioblastoma compared to normal brain tissue. MiR-124a, miR-381 and miR-637 involved regulation of pathways which commonly deregulated (MAPK/ERK, WNT/β-catenin AKT pathways, respectively). AIM: To investigate the profile prognostic/predictive role miR-124a, primary IDH-wildtype glioblastoma. Materials Methods: Inclusion criteria were:...
Background and Objectives: In the perspective of improving accuracy endoscopic ultrasound (EUS)-guided sampling, efforts innovation have focused on needle design, with development micro-core acquisition technology, puncture technique variations. Available studies shown that fine biopsy (FNB) needles can achieve a satisfactory diagnostic yield after fewer passes when compared to aspiration (FNA) needles, without an overall advantage. Limited data are available explain these results. We FNA...