A5036421142- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Alzheimer's disease research and treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Degradation and Inhibitors
- Parkinson's Disease Mechanisms and Treatments
- Organ Transplantation Techniques and Outcomes
- Memory and Neural Mechanisms
- Moyamoya disease diagnosis and treatment
- Liver Disease and Transplantation
- Diet and metabolism studies
- Calcium signaling and nucleotide metabolism
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Barrier Structure and Function Studies
- Cellular transport and secretion
- Biochemical effects in animals
- Organ Donation and Transplantation
- Cardiac electrophysiology and arrhythmias
Tokyo Medical and Dental University
2019-2024
National Institutes for Quantum Science and Technology
2020-2023
Tsuchiura Kyodo General Hospital
2019-2023
National Institutes of Health
2011
Abstract Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of seizures. Because pharmacological and surgical treatments occasionally interfere with normal brain function, more focused on-demand approach desirable. Here we examined the efficacy chemogenetic tool—designer receptors exclusively activated by designer drugs (DREADDs)—for treating focal seizure nonhuman primate model. Acute infusion GABA A receptor antagonist bicuculline into forelimb region...
Intake of specific seven essential amino acids affects the pathology brain.
Rab GTPases are important determinants of organelle identity and regulators vesicular transport pathways. Consequently, each occupies a highly specific subcellular localization. However, the precise mechanisms governing targeting remain unclear. Guanine nucleotide exchange factors (GEFs), putative membrane-resident effector binding have all been implicated as critical targeting. Here, we address these issues using Rab27a to melanosomes model system. regulates motility lysosome-related...
ABSTRACT Fibrillary tau pathologies have been implicated in Alzheimer’s and allied neurodegenerative diseases, while mechanisms by which neurons bearing tangles die remain enigmatic. To address this issue, we pursued related key macroscopically PET MRI microscopically intravital two-photon laser optics. Time-course macroscopic assays of transgenic mice demonstrated intimate associations deposition increase an inflammatory microglial marker, translocator protein (TSPO), with regional brain...
Electrocorticography(ECoG)with intracranial electrodes has a higher spatial resolution and sensitivity than conventional electroencephagrahy. Chronic VIDEO-ECoG with subdural grid been used to determine the resection border of epileptic focus, evaluate cortical function prior resective surgery. Recording multiple seizures is necessary whether they are same as habitual reproducible, allow subsequent identification seizure onset zone. It also understand ictal ECoG patterns various onsets....
Basilar artery occlusion (BAO) secondary to traumatic vertebral (VA) dissection caused by fracture is a rare cause of acute ischemic stroke, and optimal management, such as antithrombotic agents, surgical fixation, parent (PAO), has been controversial. We report case in which mechanical thrombectomy PAO were performed for BAO due right VA transverse foramen the axis vertebra.A patient her 80s suffered from backward fall, neck CT revealed dislocation lateral mass compressed foramen. The was...
我々は、出生後けいれん重積を繰り返した結節性硬化症の2カ月女児に対し、間欠期および発作時脳波で焦点と考えられたC3領域の皮質結節および周囲の焦点切除術を施行した。術中脳波で記録された2回のelectrical seizureに対し、術後にDirect Current shift（DC shift）を含むwide band analysisを行い、結節性硬化症のてんかん原性について考察した。結節周囲では発作時にspikeを認め、一部でhigh frequency oscillation（HFO）も確認できたが、ictal DC shiftは認めなかった。一方、結節部位では発作時spikeやHFOは認めなかったが、2度ともictal shiftを認めた。本症例では、発作時spikeの観察のみではてんかん原性なしと判断される結節部位にwide analysisを行うことで、結節自体にもてんかん原性が有る可能性が示唆された。
A 60-year-old woman, who experienced progressive right visual loss, was diagnosed with an unruptured large cerebral aneurysm. Magnetic resonance imaging (MRI) and angiography revealed a partially thrombosed anterior communicating artery (Acom) The aneurysmal neck located at the junction of left A1-A2 segments, dome communicated by Acom. Endovascular treatment using flow alteration technique selected. Following oral antiplatelet therapy for 9 days, balloon test occlusion (BTO) medial portion...