A5101403897- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Ophthalmology and Visual Impairment Studies
- Electrolyte and hormonal disorders
- Cardiovascular Disease and Adiposity
- Radiology practices and education
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects and Toxicity Studies
- Signaling Pathways in Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Syncope and Autonomic Disorders
- Atherosclerosis and Cardiovascular Diseases
Shanghai Institute of Hematology
2024-2025
Shanghai Ninth People's Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2022
Chongqing Medical University
2013-2022
Chongqing University
2015-2016
Huazhong University of Science and Technology
2013
Hebei Medical University
2012
Abstract Background The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) in China has been declared a public health emergency international concern. cardiac injury is common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome COVID-19 was unknown. Methods study initially enrolled 102 from continuous sample. After screening out ineligible...
Abstract Tissue nonspecific alkaline phosphatase (TNAP) is expressed widely in different tissues, modulating functions of metabolism and inflammation. However, the effect TNAP on cardiac fibrosis remains controversial needs to be further studied. The present study aims investigate role myocardial infarction (MI)-induced its mechanism. was upregulated patients with MI, both serum injured hearts, predicted in-hospital mortality. also significantly after MI rats, mostly border zone infarcted...
Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) in China has been declared a public health emergency international concern. cardiac injury was dominate the process. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome COVID-19 patients unknown. study initially enrolled 102 with pneumonia from continuous sample. After screening out ineligible cases, 54 were analyzed this study. Results...
Abstract Background In December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) emerged in Wuhan, Hubei, China. Moreover, it has become a global pandemic. This is of great value describing the clinical symptoms COVID-19 patients detail and looking for markers which are significant to predict prognosis patients. Methods this multicenter, retrospective study, 476 with were enrolled from consecutive series. After screening, total 395 included...
IMPORTANCE Identifying pediatric eye diseases at an early stage is a worldwide issue. Traditional screening procedures depend on hospitals and ophthalmologists, which are expensive time-consuming. Using artificial intelligence (AI) to assess children’s conditions from mobile photographs could facilitate convenient identification of disorders in home setting. OBJECTIVE To develop AI model identify myopia, strabismus, ptosis using photographs. DESIGN, SETTING, AND PARTICIPANTS This...
To investigate the prevalence of myopia, analyze public eye care behaviors, protective practices, and concerns regarding myopia among different age demographics. It also aimed to provide suggestions for improving dissemination science popularization about taking into account groups. Between May 2022 July 2022, we gathered data from participants through online questionnaire surveys subsequently analyzed collected responses. The research encompassed a total 393 individuals, out which 331 were...
Abstract Background: Atrial fibrosis was considered a structural basis for the development and sustaining of atrial fibrillation (AF). Transforming growth factor‐β1 (TGF‐β1) one main factors accelerating collagen production. The contribution TGF‐β1 in pathogenesis AF needs further investigation. Hypothesis: altered expression distribution will be associated with changes different types patients rheumatic heart disease (RHD). Methods: Right specimens obtained from 38 RHD undergoing mitral...
Statins are widely used in patients with cardiovascular diseases. A considerable number of previous studies revealed that the intracellular signaling transforming growth factor (TGF)‑β1 mediated development cardiomyocyte hypertrophy and interstitial fibrosis. However, whether statins can ameliorate ventricular remodeling post‑myocardial infarction via TGF‑β1 pathway remains to be rigorously tested. The left anterior descending artery was ligated induce a rat model myocardial infarction....
Comparison of the prognostic value red cell distribution width (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP) for short-term clinical outcomes in acute heart failure (AHF) patients has not been fully investigated.A total 128 with AHF were enrolled followed 3 months. Primary endpoints cardiovascular (CV) events, defined as cardiac death and/or readmission HF. Baseline RDW NT-proBNP measured at admission.The 30-day 90-day CV event rates 16.4% 35.9%, respectively. was higher...
Abnormal sympathetic hyperactivity has been shown to lead pulmonary arterial hypertension (PAH) deterioration. The purpose of this study was examine whether the transection cervical trunk (TCST) can inhibit progression PAH in a monocrotaline (MCT)-induced model and elucidate underlying mechanisms. Rats were randomly divided into four groups, including control group, an MCT + sham group TCST group. After performing haemodynamic echocardiographic measurements, rats sacrificed for histological...
Urapidil is putatively effective for patients with hypertension and acute heart failure, although randomized controlled trials thereon are lacking. We investigated the efficacy safety of intravenous urapidil relative to that nitroglycerin in older failure a trial.Patients (>60 y) were randomly assigned receive (n=89) or (n=91) 7 days. Hemodynamic parameters, cardiac function, outcomes compared.Patients group had significantly lower mean systolic blood pressure (110.1±6.5 mm Hg) than those...
The aim of this study is to investigate clinical characteristics and fatal outcomes hypertension as well the role angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) use in patients with severe coronavirus disease 2019 (COVID-19). A total 220 (female: 51.8%) COVID-19 were included. mean age included was 59.5 years 70 (31.8%) had a history hypertension. There 23 (32.9%) receiving ACEI/ARB therapy. Patients older more comorbidities, likely suffer from inflammatory...
The present study compared the prognostic value of a marker, C-terminal section arginine vasopressin prohormone (copeptin), with N-terminal B-type natriuretic peptide (NT-proBNP) in patients severe acute decompensated heart failure. A prospective, observational cohort was conducted tertiary care hospital and enrolled 129 Clinicians were blinded to investigational markers except NT-proBNP, participants followed up for 90 days. end-point composite cardiovascular death or re-hospitalization due...
BACKGROUND Revascularization is a successful therapeutic strategy for myocardial infarction. However, restoring coronary blood flow can lead to ischemia-reperfusion (I/R) injury. Low-dose 4-hydroxy-2-nonenal (HNE) therapy appears play key role in tolerance I/R We hypothesized that the positive effects of HNE on injury may be UCP3-dependent. MATERIAL AND METHODS Adult male wild-type (WT) or UCP3 knockout (UCP3-/-) mice were pre-treated with UCP inhibitor genipin saline 1 h before ischemia and...
The aims of this study were to investigate the association between different obesity indices and left ventricular mass (LVM) develop interventions for obese hypertensive patients delay progression hypertrophy (LVH). visceral adiposity index (VAI) LVM was explored using multiple regression analysis in all subjects (<i>n</i> = 1,035), subgroups aged &#x3c; 65 713) ≥65 years 322), perimenopausal women 319). VAI only associated with LVH (OR 1.134; 95% CI 1.025–1.254,...