A5062487021- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Invertebrate Immune Response Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiovascular Function and Risk Factors
- Aquaculture Nutrition and Growth
- Mosquito-borne diseases and control
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Wnt/β-catenin signaling in development and cancer
- Advanced MRI Techniques and Applications
- Hereditary Neurological Disorders
- Cancer-related gene regulation
- Marine Ecology and Invasive Species
- Cardiac pacing and defibrillation studies
- Lipid metabolism and disorders
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Cardiac electrophysiology and arrhythmias
- Peroxisome Proliferator-Activated Receptors
- Neurobiology and Insect Physiology Research
Women's Hospital, School of Medicine, Zhejiang University
2018-2025
First Affiliated Hospital Zhejiang University
2024
Second Affiliated Hospital of Zhejiang University
2022
Zhejiang University
2018-2020
Atg101 is an autophagy-related gene identified in worms, flies, mice, and mammals, which encodes a protein that functions autophagosome formation by associating with the ULK1-Atg13-Fip200 complex. In last few years, critical role of autophagy has been well-established through biochemical studies determination its structure. However, Atg101's physiological role, both during development adulthood, remains less understood. Here, we describe generation characterization loss-of-function mutant...
Abstract Adult progenitor cells in the trachea of Drosophila larvae are activated and migrate out niches when metamorphosis induces tracheal remodeling. Here we show that response to metabolic deficiency decaying branches, signaling by insulin pathway controls regulating Yorkie (Yki)-dependent proliferation migration. Yki, a transcription coactivator is regulated Hippo signaling, promotes transcriptional activation cell cycle regulators components extracellular matrix cells. These findings...
The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development physiology. Regulation of occurs at multiple levels tissues cell types. Here, we show that the histone deacetylase HDAC1 acts as a positive regulator during Drosophila wing development. Depletion causes notches on margin adult wing. Consistently, expression target genes reduced absence formation. We further provide evidence upstream activation. Mechanistically, regulates...
Abstract Control of organ size is a fundamental aspect in biology and plays important roles development. The Hippo pathway conserved signaling cascade that controls tissue through the regulation cell proliferation apoptosis. Here, we report on Hcf (host factor), Drosophila homolog Host factor 1, regulating pathway. Loss-of-Hcf function causes undergrowth down-regulation target gene expression. Genetic analysis reveals required for pathway-mediated overgrowth. Mechanistically, show associates...
Rationale: Cardiomyocytes (CMs) undergo dramatic structural and functional changes in postnatal maturation; however, the regulatory mechanisms remain greatly unclear.Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is an essential sarcomere component maintaining Z-disc stability.Deletion of mouse Cypher mutation human ZASP result dilated cardiomyopathy (DCM).Whether Cypher/ZASP participates CM maturation thereby affects cardiac function has not been answered.Methods:...
ABSTRACT Maintenance of motor neuron structure and function is crucial in development behaviour. However, the genetic regulatory mechanism remains less well understood. In present study, we identify a novel neuroprotective role microRNA miR-969 Drosophila neurons. highly expressed Loss results early-onset age-progressive locomotion impairment. Flies lacking also exhibit shortened lifespan. Moreover, required We further kay as functionally important target miR-969. Together, our indicate that...