A5021052258- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Chronic Disease Management Strategies
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Systemic Sclerosis and Related Diseases
- Healthcare cost, quality, practices
- HIV/AIDS Research and Interventions
- Health disparities and outcomes
- Acute Ischemic Stroke Management
- Global Health Care Issues
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Grit, Self-Efficacy, and Motivation
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Systems and Reforms
- Health, psychology, and well-being
- HIV-related health complications and treatments
- Meta-analysis and systematic reviews
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Diabetes Treatment and Management
- Lymphoma Diagnosis and Treatment
University of Asia and the Pacific
2016-2024
Takeda (Singapore)
2024
Bir Hospital
2023
Mexfam
2023
Mexican Social Security Institute
2023
Sunrise Medical (United States)
2022
Singapore General Hospital
2018-2021
Research Institute for Tropical Medicine
2019
University of Cape Town
2017
University of Bern
2017
Objectives With aging of the HIV ‐positive population, cardiovascular disease ( CVD ) increasingly contributes to morbidity and mortality. We investigated ‐related other causes death COD s) factors associated with in a multi‐country Asian cohort. Methods Patient data from 2003–2017 were obtained Therapeutics, Research, Education AIDS Training Asia (TREAT Asia) Observational Database TAHOD ). included patients on antiretroviral therapy ART > 1 day follow‐up. Cumulative incidences plotted...
KEY FINDINGS
 Current evidence does NOT support use of IgM/IgG rapid test kits for the definitive diagnosis COVID-19 in currently symptomatic patients.
 • The present standard is through qualitative detection virus nucleic acid via reverse transcription polymerase chain reaction (RT-PCR).
 Due to long turnaround times and complicated logistical operations, a simple field alternative needed diagnose screen An direct measurement viral load (RT-PCR) specific antibodies COVID-19....
Health-related quality of life (HRQOL) instruments are sometimes used without explicit understanding which HRQOL domains important to a given population. In this study, we sought elicit an importance hierarchy among 27 (derived from the general population) via best-worst scaling survey population in Singapore, and determine whether these were consistently valued across gender, age, ethnicity, presence chronic illnesses. We conducted community-based study that sampled participants with quotas...
The increasing focus of healthcare systems worldwide on long-term care highlights the need for culturally sensitive Health-Related Quality Life instruments to accurately capture perceived health various populations. Such require a contextualized conceptual framework domains, which is lacking in some socio-cultural contexts. We developed comprehensive and domains relevant Singaporean population. recruited Singaporeans/ permanent residents, English/ Chinese-speaking, with/ without chronic...
Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons.To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs lower-income countries.We used online questionnaires to collect program-level data on 47 ART Southern Africa (n = 14), East 8), West 7), Central 5), Latin America 7) Asia-Pacific 6 programs) 2012. Patient-level were collected 1002 adult patients seen...
To develop separate item banks for three health domains of health-related quality life (HRQOL) ranked as important by Singaporeans - physical functioning, social relationships, and positive mindset.We adapted the Patient Reported Outcomes Measurement Information System Qualitative Item Review protocol, with input endorsement from laymen experts various relevant fields. Items were generated 3 sources: 1) thematic analysis focus groups in-depth interviews framework (n = 134 participants)...
Social relationships (SR) is an important domain of health-related quality life. We developed and calibrated a novel item bank to measure SR in Singapore, multi-ethnic city Southeast Asia. initial candidate pool 51 items from focus groups, individual in-depth interviews existing instruments that had been and/or validated for use Singapore. administered all English multi-stage sample subjects, stratified age gender, with without medical conditions, recruited community hospital settings. their...
Information on the magnitude and durability of humoral immunity against COVID-19 among specific populations can guide policies vaccination, return from isolation physical distancing measures. The study determined SARS-CoV-2 antibodies after an initial infection Filipinos in Metro Manila, Philippines, extent protection confer reinfection. We conducted a cohort to monitor antibody levels patients diagnosed with COVID-19. Receptor-binding domain (RBD)-specific were measured at Days 21, 90, 180,...
The COVID-19 pandemic directly increased mortality and morbidity globally. In addition, it has had extensive indirect ill effects on healthcare service delivery across health systems worldwide. We aimed to describe how patient access diabetes care was affected by the in Manila, Philippines. used an explanatory, sequential mixed method approach including a cross-sectional survey (n = 150) in-depth interviews of patients 19), focus group discussions workers 22), key informant facility...
Abstract Background Advanced therapies (ATs) with different mechanisms of action and routes administration (RoA) are used for inflammatory bowel disease (IBD: Crohn’s [CD] ulcerative colitis [UC]), patients (pts) play an increasing role in the decision-making process.Pts’ preferences treatment attributes from 7 European countries have been reported previously; however, evidence non-European is lacking. Methods Adult pts CD or UC on ≥6 months Argentina, Australia, Brazil, Saudi Arabia Taiwan...
Positive mindset (PM) is an important domain of health-related quality life in Singapore, a multi-ethnic urban city state Southeast Asia. We therefore developed and calibrated novel item bank to measure improve PM.We initial candidate pool 48 items from focus groups, in-depth interviews existing instruments locally validated for use Singapore. administered all English multi-stage sample stratified age gender, subjects with without medical conditions recruited the community hospital, their...
Objectives Early detection of autoimmune rheumatic diseases is crucial given their high morbidity and mortality short window opportunity to improve patient outcomes. Self-administered screening questionnaires such as the connective tissue disease questionnaire (CSQ) have been shown promote early diseases. However, optimal scoring may differ with prevalence clinical features changes in classification criteria. We compared performance 3 methods for CSQ a multi-ethnic Asian population. Methods...
To cross-culturally adapt the Hamilton axial spondyloarthritis (axial SpA) screening questionnaire and develop a Chinese version for use in multi-ethnic Asian population Singapore.Consenting participants newly referred from primary care to rheumatology specialist outpatient clinic evaluation of possible SpA were studied. The original was revised based on inputs cognitive debriefing interviews (CDIs) discussions with an expert panel rheumatologists developer. Forward back translations adapted...
Background: Coronavirus disease 2019 (COVID19) is a novel pandemic caused by the β-coronavirus SARS-CoV-2. This affects primarily respiratory organs, but vascular system may also be compromised. COVID19 lead to either coagulopathies or hemorrhagic disorders involving central nervous system. Risk factors for fatal outcome have been suggested not completely elucidated. Objectives: systematic review protocol aims identify clinical, imaging and laboratory variables associated with intra-hospital...
Background: Coronavirus disease 2019 (COVID19) is a novel pandemic caused by the β-coronavirus SARS-CoV-2. This affects primarily respiratory organs, but vascular system may also be compromised. COVID19 lead to either coagulopathies or hemorrhagic disorders involving central nervous system. Risk factors for fatal outcome have been suggested not completely elucidated. Objectives: systematic review protocol aims identify clinical, imaging and laboratory variables associated with intra-hospital...
KEY FINDINGS
 There is insufficient evidence to support the routine use of HCQ or CQ for treatment COVID-19. Results 
 from interim analyses 2 large RCTs, Recovery and Solidarity trials, reportedly showed no clinical benefit hospitalized patients with are 3 randomized controlled trials that investigated efficacy safety compared standard
 therapy. Overall quality was very low.
 Meta-analyses “COVID-19 Living Data” project suggests may increase the
 incidence adverse...