A5072793188- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Food Security and Health in Diverse Populations
- Diagnosis and treatment of tuberculosis
- Antimicrobial Resistance in Staphylococcus
- Quality and Safety in Healthcare
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Fungal Infections and Studies
- Patient Safety and Medication Errors
- Antifungal resistance and susceptibility
- Infectious Diseases and Tuberculosis
- Burn Injury Management and Outcomes
- Nosocomial Infections in ICU
- Autopsy Techniques and Outcomes
- Health, Environment, Cognitive Aging
- Bacterial biofilms and quorum sensing
Chris Hani Baragwanath Hospital
2020-2024
National Health Laboratory Service
2015-2024
University of the Witwatersrand
2023-2024
National Institute for Communicable Diseases
2023
University of KwaZulu-Natal
2015-2023
University of Cape Town
2023
St George's, University of London
2023
University of Exeter
2023
Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% these deaths could be prevented through improved treatment, efficacy currently recommended first- second-line treatment regimens for this condition is increasingly affected by high rates drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef amikacin, combination as potential...
One third of patients were colonized by Candida auris during a point-prevalence survey in neonatal unit an outbreak South Africa. The sensitivity direct PCR for rapid colonization detection was 44% compared with culture. infection incidence rate decreased 85% after the and implementation isolation/cohorting.
South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that extensively (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) 2011-2012. XDR-TB cases widely distributed geographically, with majority of districts rise incidence.
Determining the death burden for prioritising public health interventions necessitates detailed data on causal pathways to death. Postmortem minimally invasive tissue sampling (MITS), incorporating histology, molecular and microbial culture diagnostics, enhances cause-of-death attribution, particularly infectious deaths. MITS proves a valid alternative full diagnostic autopsies, especially in low- middle-income countries. In Soweto, South Africa (SA), Child Health Mortality Prevention...
There is a global concern regarding increasing colonization and/or infection of paediatric burns patients with multi-drug-resistant organisms, especially in Africa. Surveillance antimicrobial resistant patterns enables clinicians to opt for the most appropriate empiric agent according unit's susceptibility profile. This study sought compile unit-specific antibiograms comparing organism prevalence and their resistance trends unit, Chris Hani Baragwanath Academic Hospital (CHBAH) from January...
Rapid diagnosis of drug-resistant Mycobacterium tuberculosis is a challenge in low-income countries. Phenotypic drug susceptibility testing using Sensititre® MycoTB assay and the resazurin microtitre plate (REMA) are relatively new innovative methods to determine susceptibility.This study aimed performance Sensititre REMA for M. high-volume reference laboratory.A laboratory-based was performed at Inkosi Albert Luthuli Central Hospital Tuberculosis Laboratory from January 2014 June 2015. The...
Methicillin-resistant Staphylococcus aureus (MRSA) colonisation and infections have a significant impact on individual patients institutions. Therefore, continuous epidemiological surveillance of MRSA, including genotypic analysis, is important to obtain better understanding the dynamics these microorganisms. We were able identify an increase in MRSA prevalence adjoining renal dermatology units our central academic hospital KwaZulu-Natal as result local programme. Here, we report findings...
Abstract Objectives Several recent studies highlight the high prevalence of resistance to multiple antibiotic classes used in current treatment regimens for neonatal sepsis and new options are urgently needed. We aimed identify potential combination by investigating drug-resistance genetic profiles most frequently isolated Gram-negative bacteria causing low- middle-income countries (LMICs) NeoOBS study. Material methods from neonates with culture-confirmed 13 clinical sites nine countries,...
Background: A recent study using minimally invasive tissue sampling at Chris Hani Baragwanath Academic Hospital (CHBAH), a public tertiary-care hospital in South Africa, reported that 70% of preterm neonatal deaths were due to healthcare-associated infections (HAIs). Based on these findings, CHBAH collaboration with the CDC conducted an infection prevention and control (IPC) assessment identified IPC gaps: limited training mentorship staff, medication preparation near patient zone,...