A5100390925- SARS-CoV-2 and COVID-19 Research
- Rabies epidemiology and control
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Influenza Virus Research Studies
- Adipose Tissue and Metabolism
- COVID-19 diagnosis using AI
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- Drug-Induced Hepatotoxicity and Protection
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- Antioxidant Activity and Oxidative Stress
- Evolution and Genetic Dynamics
- Fatty Acid Research and Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Immune responses and vaccinations
- HIV/AIDS Research and Interventions
Beijing Biocytogen (China)
2024
Jinyintan Hospital
2023
Wuhan Institute of Virology
2023
Huazhong University of Science and Technology
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Academy of Medical Sciences
2023
Emory University
2022
Hong Kong Polytechnic University
2021-2022
Institute of Endemic Disease Control in Shandong Province
2018
Objective To investigate if the addition of bedaquiline and clofazimine to a treatment regimen for multidrug-resistant tuberculosis (MDR-TB) could improve patient outcomes. Methods A prospective, randomized, controlled study was conducted in patients with MDR-TB. Treatment 18 months. Patients experimental group received their regular whereas control did not. Results 68 MDR-TB were randomised treatment, 34 each group. At end cure rates statistically significantly greater compared (82% vs....
In the face of emerging variants SARS-CoV-2, there is an urgent need to develop a vaccine that can induce fast, effective, long-lasting and broad protective immunity against SARS-CoV-2. Here, we developed trimeric SARS-CoV-2 S protein candidate adjuvanted by PIKA, which robust cellular humoral immune responses. The results showed high level neutralizing antibodies induced was maintained for at least 400 days. study non-human primates, PIKA S-trimer neutralization titers protected from virus...
<abstract> <p>The COVID-19 pandemic caused multiple waves of mortality in South Africa, where three genetic variants SARS-COV-2 and their ancestral strain dominated consecutively. State-of-the-art mathematical modeling approach was used to estimate the time-varying transmissibility relative Beta, Delta, Omicron variants. The were about 73%, 87%, 276% higher than preceding To best our knowledge, model is first simple that can simulate variants' replacements Africa. variant...
This phase I study aimed to assess the safety, tolerability, and immunogenicity of PIKA-adjuvanted recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine in healthy adults aged 18 years older.
Background: COVID-19 pandemic caused multiple mortality waves in South Africa. At the same time, wild strain and three variants of SARS-COV-2 dominated turn. Method: We used state-of-the-art mathematical modeling to estimate time-varying transmissibility relative variants, ie, Beta, Delta Omicron.Result: found that Omicron are about 73%, 87%, 276% higher than their proceeding variants.Conclusion: To best our knowledge, model is first simple which can simulate variant replacements The...
This study evaluated the safety and immunogenicity of PIKA-adjuvanted recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein subunit vaccine as a booster dose for healthy adults who had previously received two or more doses an inactivated disease 2019 (COVID-19) vaccine.
Rabies is a fatal zoonotic disease caused by the rabies virus. Despite existing vaccines, failures still persist. Complete protection relies on improving vaccination for delayed antibody response and weak cellular immunity. A more effective secure vaccine necessary prevention. For this purpose, we employed use of PIKA adjuvant, stabilized double-stranded RNA that interacts with TLR3, as an enhancer immunization. Testing mice infected seven strains prevalent in China showed over 80%...
SUMMARY Background This COVID-19 pandemic has caused unprecedented morbidity, mortality, and global economic instability. Several approved vaccines demonstrated to be effective prevention against COVID-19. We aimed evaluate the safety immunogenicity of PIKA-adjuvanted recombinant SARS-C0V-2 Spike (S) protein subunit vaccine in adults as a primary immunization booster dose infection. Methods was Phase I, open label, dose-escalation study 3 levels SARS-CoV-2 spike antigen administered...
Abstract Recently SARS-CoV-2 Omicron (B.1.1.529) variant was identified in South Africa with numerous mutations spike protein, and community infections have been reported raised grave concern around the world. Some studies found that neutralization effects of several licensed vaccines against were dramatically reduced, which significantly affected antibody mediated protection, especially for individuals whose immunization completed after extended period. In this regard, we studied...
Objective To investigate the current condition and risk factors of Keshan disease (KD) in Shandong Province, to provide a scientific basis for prevention control KD. Methods Based on 2014 scheme KD surveillance, residents 38 surveillance sites 19 counties (cities, districts) were surveyed by questionnaire survey, physical examination, electrocardiograms (ECG), X-ray or echocardiography. At same time, some residents' hair, grain soil samples collected, content selenium internal...